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MED29 mediator complex subunit 29 [ Homo sapiens (human) ]

Gene ID: 55588, updated on 11-Apr-2024

Summary

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Official Symbol
MED29provided by HGNC
Official Full Name
mediator complex subunit 29provided by HGNC
Primary source
HGNC:HGNC:23074
See related
Ensembl:ENSG00000063322 MIM:612914; AllianceGenome:HGNC:23074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IXL; MED2
Summary
MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009]
Expression
Ubiquitous expression in brain (RPKM 2.7), thyroid (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

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See MED29 in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39391378..39400641)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42195658..42204924)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39882018..39891281)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4B Neighboring gene RNA, 7SL, cytoplasmic 566, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:39880404-39880535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14613 Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14615 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39893943-39894450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39897901-39898538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39898539-39899177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39899178-39899815 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:39900078-39900668 Neighboring gene microRNA 4530 Neighboring gene ZFP36 ring finger protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification. Kuuselo R, et al. Cancer Res, 2007 Mar 1. PMID 17332321
  2. IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. Wang Y, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555573
  3. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. Sato S, et al. J Biol Chem, 2003 Dec 12. PMID 14576168
  4. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Davis MA, et al. Genes Dev, 2013 Jan 15. PMID 23322298, Free PMC Article
  5. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Zhang X, et al. Mol Cell, 2005 Jul 1. PMID 15989967

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IXL is required for cancer cell survival in 19q13-amplified tumors.
    Title: Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification.
  2. Overexpression of IXL in COS-7 cells inhibits the transcriptional activities of SRE and AP-1, suggesting that the IXL protein may act as a transcriptional suppressor in mitogen-activated protein kinase signaling pathway to mediate cellular functions.
    Title: IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor.
  3. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex
    Title: A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.
  4. IXL is a subunit of the mammalian Mediator complex.
    Title: A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.
  5. IXL is a subunit of the mammalian Mediator complex.
    Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434H247

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 29
Names
intersex-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317770.3 → NP_001304699.2  mediator of RNA polymerase II transcription subunit 29 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice acceptor site in the 3' coding region, which results in a frame-shift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC011500, AK124629, AK298014, AY729650, BQ271530
    Consensus CDS
    CCDS92614.1
    UniProtKB/TrEMBL
    M0R3F3
    Related
    ENSP00000472501.2, ENST00000594368.5
    Conserved Domains (1) summary
    pfam11568
    Location:53 → 120
    Med29; Mediator complex subunit 29

  2. NM_017592.4 → NP_060062.2  mediator of RNA polymerase II transcription subunit 29 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC011500, AK124629, AY729650, BQ271530
    Consensus CDS
    CCDS33021.2
    UniProtKB/Swiss-Prot
    B4DNQ6, M0R2E4, Q5XX09, Q9NTF4, Q9NX70
    UniProtKB/TrEMBL
    B4DN56
    Related
    ENSP00000314343.5, ENST00000315588.11
    Conserved Domains (1) summary
    pfam11568
    Location:53 → 187
    Med29; Mediator complex subunit 29

RNA

  1. NR_133915.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011500, AK090877, AY729650, BQ271530

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39391378..39400641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    42195658..42204924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NX70.1 GenPept UniProtKB/Swiss-Prot:Q9NX70

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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