U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SRGN serglycin [ Homo sapiens (human) ]

Gene ID: 5552, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
SRGNprovided by HGNC
Official Full Name
serglycinprovided by HGNC
Primary source
HGNC:HGNC:9361
See related
Ensembl:ENSG00000122862 MIM:177040; AllianceGenome:HGNC:9361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPG; PRG; PRG1
Summary
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Biased expression in bone marrow (RPKM 1650.2), appendix (RPKM 289.1) and 5 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SRGN in Genome Data Viewer
Location:
10q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (69087603..69104811)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (69925937..69973238)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70847359..70864567)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2425 Neighboring gene ACTB pseudogene 14 Neighboring gene uncharacterized LOC105378342 Neighboring gene Sharpr-MPRA regulatory region 5024 Neighboring gene MPRA-validated peak1005 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:70812477-70812978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:70812979-70813478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3484 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16959 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:70828777-70829328 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16968 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:70847990-70849189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:70884392-70884898 Neighboring gene VPS26 retromer complex component A Neighboring gene ribosomal protein S12 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3486 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:70949649-70949852 Neighboring gene Suv3 like RNA helicase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2429

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Clinical Significance of Serglycin Expression in Human Breast Cancer Patients. Hosoya K, et al. Anticancer Res, 2022 Jan. PMID 34969735
  2. Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone. He Y, et al. Cell Death Dis, 2021 Sep 23. PMID 34556636, Free PMC Article
  3. The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy. Wang L, et al. J Clin Lab Anal, 2021 Mar. PMID 33314317, Free PMC Article
  4. Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study. Li Y, et al. Comb Chem High Throughput Screen, 2021. PMID 33081679
  5. SRGN, a new identified shear-stress-responsive gene in endothelial cells. Ma Q, et al. Mol Cell Biochem, 2020 Nov. PMID 32712749

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin: Erratum.
    Title: miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin: Erratum.
  2. Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration.
    Title: Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration.
  3. SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas.
    Title: SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas.
  4. Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.
    Title: Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.
  5. Clinical Significance of Serglycin Expression in Human Breast Cancer Patients.
    Title: Clinical Significance of Serglycin Expression in Human Breast Cancer Patients.
  6. The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a beta-catenin-dependent manner.
    Title: The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.
  7. Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study.
    Title: Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study.
  8. The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy.
    Title: The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy.
  9. SRGN, a new identified shear-stress-responsive gene in endothelial cells.
    Title: SRGN, a new identified shear-stress-responsive gene in endothelial cells.
  10. SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression.
    Title: SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC9289, FLJ12930

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell secretory granule organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biomineral tissue development IEA
Inferred from Electronic Annotation
more info
  
involved_in granzyme-mediated programmed cell death signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maintenance of granzyme B location in T cell secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maintenance of protease location in mast cell secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mast cell secretory granule organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of bone mineralization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of bone mineralization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in secretory granule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytolytic granule IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mast cell granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serglycin
Names
hematopoetic proteoglycan core peptide
hematopoetic proteoglycan core protein
hematopoietic proteoglycan core protein
p.PG
platelet proteoglycan core protein
proteoglycan 1, secretory granule
proteoglycan protein core for mast cell secretory granule
secretory granule proteoglycan core peptide
secretory granule proteoglycan core protein
serglycin proteoglycan

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321053.2 → NP_001307982.1  serglycin isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 3 encode isoform 1.
    Source sequence(s)
    AL442635, BC015516, BP363056
    Consensus CDS
    CCDS7285.1
    UniProtKB/Swiss-Prot
    B2R4L7, P10124, Q5VW06
    Conserved Domains (1) summary
    pfam04360
    Location:3 → 150
    Serglycin

  2. NM_001321054.1 → NP_001307983.1  serglycin isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon in the coding region resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter, has a distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.
    Source sequence(s)
    AI347627, AL442635, BC015516, BP335278, BQ051861, CD677686
    UniProtKB/Swiss-Prot
    P10124
    Conserved Domains (1) summary
    pfam04360
    Location:22 → 94
    Serglycin; Serglycin

  3. NM_002727.4 → NP_002718.2  serglycin isoform 1 precursor

    See identical proteins and their annotated locations for NP_002718.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon in the 5' UTR compared to variant 2. Both variants 1 and 3 encode isoform 1.
    Source sequence(s)
    BC015516, BG057351, BG548665, CA308463, CB110512
    Consensus CDS
    CCDS7285.1
    UniProtKB/Swiss-Prot
    B2R4L7, P10124, Q5VW06
    Related
    ENSP00000242465.3, ENST00000242465.4
    Conserved Domains (1) summary
    pfam04360
    Location:3 → 150
    Serglycin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    69087603..69104811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    69925937..69973238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366246.1 → XP_054222221.1  serglycin isoform X1

  2. XM_054366247.1 → XP_054222222.1  serglycin isoform X1

  3. XM_054366248.1 → XP_054222223.1  serglycin isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10124.3 GenPept UniProtKB/Swiss-Prot:P10124

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous