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TNFRSF19 TNF receptor superfamily member 19 [ Homo sapiens (human) ]

Gene ID: 55504, updated on 10-Mar-2024

Summary

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Official Symbol
TNFRSF19provided by HGNC
Official Full Name
TNF receptor superfamily member 19provided by HGNC
Primary source
HGNC:HGNC:11915
See related
Ensembl:ENSG00000127863 MIM:606122; AllianceGenome:HGNC:11915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAJ; TROY; TRADE; TAJ-alpha
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 37.6), prostate (RPKM 12.9) and 8 other tissues See more
Orthologs
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Genomic context

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Location:
13q12.12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (23570412..23676093)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (22776896..22882553)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (24144551..24250232)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 327 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24066632-24067132 Neighboring gene uncharacterized LOC124903135 Neighboring gene NANOG hESC enhancer GRCh37_chr13:24081975-24082502 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:24100455-24101050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24141962-24142474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24142475-24142986 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5175 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32745 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:24192537-24193038 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:24195169-24195668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:24205756-24206564 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:24206565-24207373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24213321-24213822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:24228053-24228554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7460 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:24269883-24270456 Neighboring gene uncharacterized LOC105370113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7462 Neighboring gene mitochondrial intermediate peptidase Neighboring gene MT-CO3 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance. Ding Z, et al. Neoplasia, 2020 Sep. PMID 32629176, Free PMC Article
  2. The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression. Shao L, et al. Genome Biol, 2019 May 24. PMID 31126313, Free PMC Article
  3. TROY expression is associated with pathological stage and poor prognosis in patients treated with radical cystectomy. Nomura M, et al. Cancer Biomark, 2019. PMID 30475756
  4. TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance. Loftus JC, et al. Mol Cancer Res, 2013 Aug. PMID 23699535, Free PMC Article
  5. Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target. Spanjaard RA, et al. Int J Cancer, 2007 Mar 15. PMID 17187358

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TNFRSF19 within the 13q12.12 Risk Locus Functions as a Lung Cancer Suppressor by Binding Wnt3a to Inhibit Wnt/beta-Catenin Signaling.
    Title: TNFRSF19 within the 13q12.12 Risk Locus Functions as a Lung Cancer Suppressor by Binding Wnt3a to Inhibit Wnt/β-Catenin Signaling.
  2. Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression.
    Title: Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression.
  3. Unique molecular characteristics of NAFLD-associated liver cancer accentuate beta-catenin/TNFRSF19-mediated immune evasion.
    Title: Unique molecular characteristics of NAFLD-associated liver cancer accentuate β-catenin/TNFRSF19-mediated immune evasion.
  4. Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
    Title: Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
  5. TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance.
    Title: TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance.
  6. Downregulation of TNFRSF19 and RAB43 by a novel miRNA, miR-HCC3, promotes proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cells.
    Title: Downregulation of TNFRSF19 and RAB43 by a novel miRNA, miR-HCC3, promotes proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cells.
  7. tumor marker tumor necrosis factor receptor superfamily member 19 as part of a four gene transcript score has prognostic value for metastatic-lethal progression in men treated for localized prostate cancer
    Title: A four-gene transcript score to predict metastatic-lethal progression in men treated for localized prostate cancer: Development and validation studies.
  8. Study showed that TNFRSF19 is highly expressed in nasopharyngeal carcinoma (NPC) and is required for cell proliferation and NPC development. TNFRSF19 was not involved in NFkappaB activation or associated with TRAF proteins. TbetaRI was identified as a specific binding partner for TNFRSF19. TNFRSF19 bound the kinase domain of TbetaRI in the cytoplasm, thereby blocking Smad2/3 association with TbetaRI and subsequent sign...
    Title: TNFRSF19 Inhibits TGFβ Signaling through Interaction with TGFβ Receptor Type I to Promote Tumorigenesis.
  9. three inherited variations at rs17336602 (G>C), rs4770489 (A>G), and rs34354770 (A>C) in 13q12.12 contribute to lung cancer risk and development by declining p53-responsive enhancer-mediated TNFRSF19 activation
    Title: The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression.
  10. TROY may therefore be a new molecular marker to aid in identifying and selecting patients undergoing radical cystectomy who could potentially benefit from multimodal treatment.
    Title: TROY expression is associated with pathological stage and poor prognosis in patients treated with radical cystectomy.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
EBI GWAS Catalog
Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Novel associations for hypothyroidism include known autoimmune risk loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tumor necrosis factor receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in hair follicle development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 19
Names
toxicity and JNK inducer

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204458.3 → NP_001191387.1  tumor necrosis factor receptor superfamily member 19 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and the 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform (1). Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AY358888, BC047321, BF968836, BF971156, BM801444, DB223760
    Consensus CDS
    CCDS9301.1
    UniProtKB/Swiss-Prot
    Q9NS68
    Related
    ENSP00000371698.3, ENST00000382263.3
    Conserved Domains (1) summary
    cd13418
    Location:33 → 149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

  2. NM_001204459.2 → NP_001191388.1  tumor necrosis factor receptor superfamily member 19 isoform 3

    See identical proteins and their annotated locations for NP_001191388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in both UTR's and the 3' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK304290, AY358888, BC047321, BF968836, BF971156, BM801444, DA192370
    Consensus CDS
    CCDS55893.1
    UniProtKB/Swiss-Prot
    Q9NS68
    Related
    ENSP00000385408.2, ENST00000403372.6
    Conserved Domains (1) summary
    cl22855
    Location:1 → 17
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  3. NM_001354985.2 → NP_001341914.1  tumor necrosis factor receptor superfamily member 19 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL161422, AL354815
    Conserved Domains (1) summary
    cd13418
    Location:33 → 149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

  4. NM_018647.5 → NP_061117.2  tumor necrosis factor receptor superfamily member 19 isoform 1 precursor

    See identical proteins and their annotated locations for NP_061117.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as TRADEbeta) encodes the longest isoform (1).
    Source sequence(s)
    AF167555, AL161422, BC047321, DB223760
    Consensus CDS
    CCDS9302.1
    UniProtKB/Swiss-Prot
    A8KA09, A8KA26, B1AM40, B1AM41, B4E2I6, Q9BXZ9, Q9BY00, Q9NS68, Q9NZV2
    Related
    ENSP00000371693.4, ENST00000382258.8
    Conserved Domains (1) summary
    cd13418
    Location:33 → 149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

  5. NM_148957.4 → NP_683760.1  tumor necrosis factor receptor superfamily member 19 isoform 2 precursor

    See identical proteins and their annotated locations for NP_683760.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as TRADEalpha) differs in both UTR's and the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform (1). Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AY358888, BC047321, BF968836, BF971156, BM801444, DA192370
    Consensus CDS
    CCDS9301.1
    UniProtKB/Swiss-Prot
    Q9NS68
    Related
    ENSP00000248484.4, ENST00000248484.9
    Conserved Domains (1) summary
    cd13418
    Location:33 → 149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    23570412..23676093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430440.1 → XP_047286396.1  tumor necrosis factor receptor superfamily member 19 isoform X1

  2. XM_047430442.1 → XP_047286398.1  tumor necrosis factor receptor superfamily member 19 isoform X2

  3. XM_005266446.3 → XP_005266503.1  tumor necrosis factor receptor superfamily member 19 isoform X2

    See identical proteins and their annotated locations for XP_005266503.1

    Conserved Domains (1) summary
    cd13418
    Location:33 → 149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

  4. XM_047430441.1 → XP_047286397.1  tumor necrosis factor receptor superfamily member 19 isoform X1

  5. XM_047430443.1 → XP_047286399.1  tumor necrosis factor receptor superfamily member 19 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    22776896..22882553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374673.1 → XP_054230648.1  tumor necrosis factor receptor superfamily member 19 isoform X1

  2. XM_054374676.1 → XP_054230651.1  tumor necrosis factor receptor superfamily member 19 isoform X2

  3. XM_054374675.1 → XP_054230650.1  tumor necrosis factor receptor superfamily member 19 isoform X2

  4. XM_054374674.1 → XP_054230649.1  tumor necrosis factor receptor superfamily member 19 isoform X1

  5. XM_054374677.1 → XP_054230652.1  tumor necrosis factor receptor superfamily member 19 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NS68.1 GenPept UniProtKB/Swiss-Prot:Q9NS68

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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