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GPALPP1 GPALPP motifs containing 1 [ Homo sapiens (human) ]

Gene ID: 55425, updated on 3-Apr-2024

Summary

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Official Symbol
GPALPP1provided by HGNC
Official Full Name
GPALPP motifs containing 1provided by HGNC
Primary source
HGNC:HGNC:20298
See related
Ensembl:ENSG00000133114 AllianceGenome:HGNC:20298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LSR7; AD029; KIAA1704; bA245H20.2
Expression
Ubiquitous expression in endometrium (RPKM 5.8), thyroid (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
13q14.12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (44989538..45037669)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (44209620..44257727)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45563673..45611804)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7675 Neighboring gene tRNA-Glu (anticodon TTC) 2-1 Neighboring gene nuclear FMR1 interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 6953 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45563144-45563782 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:45563783-45564419 Neighboring gene RNA, 7SL, cytoplasmic 49, pseudogene Neighboring gene uncharacterized LOC105370188 Neighboring gene uncharacterized LOC107984596 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:45629620-45630819

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Dec 31. PMID 11214970
  2. KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Kumar A, et al. Cell Rep, 2022 May 10. PMID 35545047, Free PMC Article
  3. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. Lu L, et al. J Biol Chem, 2013 Dec 13. PMID 24163370, Free PMC Article
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Taipale M, et al. Cell, 2014 Jul 17. PMID 25036637, Free PMC Article
  5. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. Elzi DJ, et al. J Proteome Res, 2014 Aug 1. PMID 24999758, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1704

General protein information

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Preferred Names
GPALPP motifs-containing protein 1
Names
lipopolysaccharide specific response-7 protein
lipopolysaccharide-specific response protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316951.2 → NP_001303880.1  GPALPP motifs-containing protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK292493, AL359706, CF528444, DC333111
    Consensus CDS
    CCDS9394.1
    UniProtKB/Swiss-Prot
    A8K8X8, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q8IXQ4, Q9C0F9, Q9H2R0, Q9P0W6
    UniProtKB/TrEMBL
    A0A0A0MRI1
    Conserved Domains (1) summary
    pfam12572
    Location:196 → 332
    DUF3752; Protein of unknown function (DUF3752)

  2. NM_001316952.2 → NP_001303881.1  GPALPP motifs-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction and differs in the 3' UTR compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL138693, AL359706, BC032333, DC333111
    UniProtKB/Swiss-Prot
    Q8IXQ4
    Conserved Domains (1) summary
    pfam12572
    Location:73 → 209
    DUF3752; Protein of unknown function (DUF3752)

  3. NM_018559.5 → NP_061029.2  GPALPP motifs-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_061029.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL359706, BC039586, DC333111
    Consensus CDS
    CCDS9394.1
    UniProtKB/Swiss-Prot
    A8K8X8, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q8IXQ4, Q9C0F9, Q9H2R0, Q9P0W6
    UniProtKB/TrEMBL
    A0A0A0MRI1
    Related
    ENSP00000368447.4, ENST00000379151.9
    Conserved Domains (1) summary
    pfam12572
    Location:196 → 332
    DUF3752; Protein of unknown function (DUF3752)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    44989538..45037669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430436.1 → XP_047286392.1  GPALPP motifs-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K8X8, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q8IXQ4, Q9C0F9, Q9H2R0, Q9P0W6
    Related
    ENSP00000432500.1, ENST00000497558.5

  2. XM_005266444.4 → XP_005266501.1  GPALPP motifs-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005266501.1

    UniProtKB/Swiss-Prot
    A8K8X8, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q8IXQ4, Q9C0F9, Q9H2R0, Q9P0W6
    UniProtKB/TrEMBL
    A0A0A0MRI1
    Conserved Domains (1) summary
    pfam12572
    Location:196 → 332
    DUF3752; Protein of unknown function (DUF3752)

  3. XM_047430438.1 → XP_047286394.1  GPALPP motifs-containing protein 1 isoform X4

  4. XM_011535144.3 → XP_011533446.1  GPALPP motifs-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011533446.1

    Conserved Domains (1) summary
    pfam12572
    Location:73 → 209
    DUF3752; Protein of unknown function (DUF3752)

  5. XM_047430437.1 → XP_047286393.1  GPALPP motifs-containing protein 1 isoform X3

    Related
    ENSP00000350145.3, ENST00000357537.4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    44209620..44257727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374668.1 → XP_054230643.1  GPALPP motifs-containing protein 1 isoform X1

  2. XM_054374669.1 → XP_054230644.1  GPALPP motifs-containing protein 1 isoform X1

  3. XM_054374672.1 → XP_054230647.1  GPALPP motifs-containing protein 1 isoform X4

  4. XM_054374670.1 → XP_054230645.1  GPALPP motifs-containing protein 1 isoform X2

  5. XM_054374671.1 → XP_054230646.1  GPALPP motifs-containing protein 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IXQ4.1 GenPept UniProtKB/Swiss-Prot:Q8IXQ4

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