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TMEM144 transmembrane protein 144 [ Homo sapiens (human) ]

Gene ID: 55314, updated on 3-Apr-2024

Summary

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Official Symbol
TMEM144provided by HGNC
Official Full Name
transmembrane protein 144provided by HGNC
Primary source
HGNC:HGNC:25633
See related
Ensembl:ENSG00000164124 MIM:620325; AllianceGenome:HGNC:25633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC35G7
Summary
Predicted to enable carbohydrate transmembrane transporter activity. Predicted to be involved in carbohydrate transmembrane transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 40.3), duodenum (RPKM 10.7) and 13 other tissues See more
Orthologs
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Genomic context

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Location:
4q32.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (158210486..158255416)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (161562668..161607571)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (159131638..159176568)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928007 Neighboring gene GASK1B antisense RNA 1 Neighboring gene NUDT19 pseudogene 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159131026-159131580 Neighboring gene Sharpr-MPRA regulatory region 4077 Neighboring gene NANOG hESC enhancer GRCh37_chr4:159166017-159166518 Neighboring gene NANOG hESC enhancer GRCh37_chr4:159195233-159195734 Neighboring gene AIDA pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 15052 Neighboring gene uncharacterized LOC105377510

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent. Prentice LM, et al. BMC Genomics, 2011 Apr 28. PMID 21527035, Free PMC Article
  2. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
  3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 144

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018342.5 → NP_060812.2  transmembrane protein 144

    See identical proteins and their annotated locations for NP_060812.2

    Status: VALIDATED

    Source sequence(s)
    AC098679, BC054487
    Consensus CDS
    CCDS3799.1
    UniProtKB/Swiss-Prot
    D3DP24, Q49A05, Q7Z5S9, Q9NUT3
    Related
    ENSP00000296529.6, ENST00000296529.11
    Conserved Domains (1) summary
    pfam07857
    Location:9 → 344
    TMEM144; Transmembrane family, TMEM144 of transporters

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    158210486..158255416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263110.3 → XP_005263167.1  transmembrane protein 144 isoform X1

    See identical proteins and their annotated locations for XP_005263167.1

    UniProtKB/Swiss-Prot
    D3DP24, Q49A05, Q7Z5S9, Q9NUT3
    Conserved Domains (1) summary
    pfam07857
    Location:9 → 344
    TMEM144; Transmembrane family, TMEM144 of transporters

  2. XM_017008366.2 → XP_016863855.1  transmembrane protein 144 isoform X1

    UniProtKB/Swiss-Prot
    D3DP24, Q49A05, Q7Z5S9, Q9NUT3
    Conserved Domains (1) summary
    pfam07857
    Location:9 → 344
    TMEM144; Transmembrane family, TMEM144 of transporters

  3. XM_047415908.1 → XP_047271864.1  transmembrane protein 144 isoform X2

    UniProtKB/TrEMBL
    D6RDI4
    Related
    ENSP00000420930.1, ENST00000511532.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    161562668..161607571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z5S9.1 GenPept UniProtKB/Swiss-Prot:Q7Z5S9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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