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ZNF444 zinc finger protein 444 [ Homo sapiens (human) ]

Gene ID: 55311, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF444provided by HGNC
Official Full Name
zinc finger protein 444provided by HGNC
Primary source
HGNC:HGNC:16052
See related
Ensembl:ENSG00000167685 MIM:607874; AllianceGenome:HGNC:16052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EZF2; EZF-2; ZSCAN17
Summary
This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in prostate (RPKM 3.1), stomach (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.43
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56132553..56160893)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59231414..59259774)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56652656..56672262)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 787 Neighboring gene uncharacterized LOC124904773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56626767-56627443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56628849-56629564 Neighboring gene Sharpr-MPRA regulatory region 1998 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56632431-56633146 Neighboring gene uncharacterized LOC124904772 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56640200-56640700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56640701-56641201 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15116 Neighboring gene MPRA-validated peak3570 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56686512-56687062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56687063-56687613 Neighboring gene CRISPRi-validated cis-regulatory element chr19.6329 Neighboring gene galanin like peptide Neighboring gene zinc finger and SCAN domain containing 5B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. Brandal P, et al. Genes Chromosomes Cancer, 2009 Dec. PMID 19760602
  2. Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. Adachi H, et al. J Biol Chem, 2002 Jul 5. PMID 11978792
  3. Cellular substrates and pro-apoptotic function of the human HtrA4 protease. Wenta T, et al. J Proteomics, 2019 Oct 30. PMID 31470122
  4. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Diner BA, et al. Mol Syst Biol, 2015 Feb 9. PMID 25665578, Free PMC Article
  5. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 is associated with soft tissue myoepithelial carcinoma.
    Title: t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma.
  2. regulates the human gene encoding the scavenger receptor expressed by endothelial cells
    Title: Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11137

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 444
Names
endothelial zinc finger protein 2
zinc finger and SCAN domain-containing protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253792.2 → NP_001240721.1  zinc finger protein 444 isoform 2

    See identical proteins and their annotated locations for NP_001240721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AB052954, AC024580
    Consensus CDS
    CCDS59426.1
    UniProtKB/TrEMBL
    Q53F81
    Related
    ENSP00000468069.1, ENST00000592949.5
    Conserved Domains (5) summary
    PRK14959
    Location:60 → 181
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:178 → 279
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:180 → 200
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:277 → 299
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:21 → 98
    SCAN; SCAN domain

  2. NM_018337.4 → NP_060807.2  zinc finger protein 444 isoform 1

    See identical proteins and their annotated locations for NP_060807.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL834130, BI823582
    Consensus CDS
    CCDS12939.1
    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1
    UniProtKB/TrEMBL
    Q53F81
    Related
    ENSP00000338860.3, ENST00000337080.8
    Conserved Domains (5) summary
    PRK14959
    Location:60 → 182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179 → 280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:21 → 98
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56132553..56160893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451575.2 → XP_024307343.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1
    UniProtKB/TrEMBL
    Q53F81
    Conserved Domains (5) summary
    PRK14959
    Location:60 → 182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179 → 280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:21 → 98
    SCAN; SCAN domain

  2. XM_005259035.2 → XP_005259092.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_005259092.1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1
    UniProtKB/TrEMBL
    Q53F81
    Conserved Domains (5) summary
    PRK14959
    Location:60 → 182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179 → 280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:21 → 98
    SCAN; SCAN domain

  3. XM_047439042.1 → XP_047294998.1  zinc finger protein 444 isoform X2

  4. XM_005259034.3 → XP_005259091.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_005259091.1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1
    UniProtKB/TrEMBL
    Q53F81
    Conserved Domains (5) summary
    PRK14959
    Location:60 → 182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179 → 280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:21 → 98
    SCAN; SCAN domain

  5. XM_047439039.1 → XP_047294995.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  6. XM_047439038.1 → XP_047294994.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  7. XM_047439037.1 → XP_047294993.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  8. XM_024451573.2 → XP_024307341.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1
    UniProtKB/TrEMBL
    Q53F81
    Conserved Domains (5) summary
    PRK14959
    Location:60 → 182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179 → 280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:21 → 98
    SCAN; SCAN domain

  9. XM_047439041.1 → XP_047294997.1  zinc finger protein 444 isoform X2

  10. XM_005259036.2 → XP_005259093.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_005259093.1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1
    UniProtKB/TrEMBL
    Q53F81
    Conserved Domains (5) summary
    PRK14959
    Location:60 → 182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179 → 280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:21 → 98
    SCAN; SCAN domain

  11. XM_047439043.1 → XP_047294999.1  zinc finger protein 444 isoform X2

  12. XM_024451576.1 → XP_024307344.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1
    UniProtKB/TrEMBL
    Q53F81
    Conserved Domains (5) summary
    PRK14959
    Location:60 → 182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179 → 280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181 → 201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278 → 300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:21 → 98
    SCAN; SCAN domain

  13. XM_047439044.1 → XP_047295000.1  zinc finger protein 444 isoform X2

  14. XM_047439040.1 → XP_047294996.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  15. XM_017026933.2 → XP_016882422.1  zinc finger protein 444 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:82 → 154
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:102 → 122
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:114 → 139
    zf-H2C2_2; Zinc-finger double domain

  16. XM_047439045.1 → XP_047295001.1  zinc finger protein 444 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59231414..59259774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321366.1 → XP_054177341.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  2. XM_054321363.1 → XP_054177338.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  3. XM_054321371.1 → XP_054177346.1  zinc finger protein 444 isoform X2

  4. XM_054321362.1 → XP_054177337.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  5. XM_054321368.1 → XP_054177343.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  6. XM_054321367.1 → XP_054177342.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  7. XM_054321370.1 → XP_054177345.1  zinc finger protein 444 isoform X2

  8. XM_054321361.1 → XP_054177336.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  9. XM_054321360.1 → XP_054177335.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  10. XM_054321372.1 → XP_054177347.1  zinc finger protein 444 isoform X2

  11. XM_054321365.1 → XP_054177340.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  12. XM_054321364.1 → XP_054177339.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  13. XM_054321373.1 → XP_054177348.1  zinc finger protein 444 isoform X2

  14. XM_054321369.1 → XP_054177344.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q8TEQ9, Q8WU35, Q9NUU1

  15. XM_054321374.1 → XP_054177349.1  zinc finger protein 444 isoform X3

  16. XM_054321375.1 → XP_054177350.1  zinc finger protein 444 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N0Y2.1 GenPept UniProtKB/Swiss-Prot:Q8N0Y2

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