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DDX19A DEAD-box helicase 19A [ Homo sapiens (human) ]

Gene ID: 55308, updated on 5-Mar-2024

Summary

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Official Symbol
DDX19Aprovided by HGNC
Official Full Name
DEAD-box helicase 19Aprovided by HGNC
Primary source
HGNC:HGNC:25628
See related
Ensembl:ENSG00000168872 AllianceGenome:HGNC:25628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX19L; DDX19-DDX19L
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 14.8), placenta (RPKM 14.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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See DDX19A in Genome Data Viewer
Location:
16q22.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70346903..70373383)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (76157947..76184410)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70380806..70407286)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene RNA, 7SL, cytoplasmic 279, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70317824-70318022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7671 Neighboring gene Sharpr-MPRA regulatory region 7868 Neighboring gene DEAD-box helicase 19B Neighboring gene DDX19A divergent transcript Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:70366483-70367682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70379806-70380424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70380425-70381042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11055 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70421141-70421825 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11057 Neighboring gene uncharacterized LOC124903707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11059 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70458653-70459478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70461771-70462462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70462463-70463152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11061 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70464537-70465228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70467433-70467993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7673 Neighboring gene ribosomal protein S27 pseudogene 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing of let-7b-5p inhibits ovarian cancer cell proliferation and stemness characteristics by Asp-Glu-Ala-Asp-box helicase 19A. Huang X, et al. Bioengineered, 2021 Dec. PMID 34612147, Free PMC Article
  2. DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation. Li J, et al. J Immunol, 2015 Dec 15. PMID 26538395
  3. Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Lempiäinen JK, et al. Mol Cell Proteomics, 2017 Aug. PMID 28611094, Free PMC Article
  4. Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression. Yang PB, et al. Proc Natl Acad Sci U S A, 2020 Nov 3. PMID 33087562, Free PMC Article
  5. Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 Virus. Zheng X, et al. Pathogens, 2021 Sep 8. PMID 34578187, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing of let-7b-5p inhibits ovarian cancer cell proliferation and stemness characteristics by Asp-Glu-Ala-Asp-box helicase 19A.
    Title: Silencing of let-7b-5p inhibits ovarian cancer cell proliferation and stemness characteristics by Asp-Glu-Ala-Asp-box helicase 19A.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11126, DKFZp686C21137

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to zinc ion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX19A
Names
DDX19-like protein
DEAD (Asp-Glu-Ala-As) box polypeptide 19A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
DEAD box protein 19A
RNA helicase
NP_001307451.1
NP_001307454.1
NP_001307455.1
NP_001307456.1
NP_060802.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320522.2 → NP_001307451.1  ATP-dependent RNA helicase DDX19A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI863086, AK299539, BC005162, DB074731
    Consensus CDS
    CCDS82009.1
    UniProtKB/TrEMBL
    B4DS24, I3L0H8
    Related
    ENSP00000410243.2, ENST00000417604.6
    Conserved Domains (1) summary
    COG0513
    Location:100 → 446
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  2. NM_001320525.2 → NP_001307454.1  ATP-dependent RNA helicase DDX19A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI863086, BC005162, DB074731, DC375258
    UniProtKB/TrEMBL
    I3L352
    Related
    ENSP00000460180.1, ENST00000575878.1
    Conserved Domains (2) summary
    cd18787
    Location:216 → 352
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cl28899
    Location:9 → 212
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  3. NM_001320526.2 → NP_001307455.1  ATP-dependent RNA helicase DDX19A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AI863086, BC005162, CR749227
    UniProtKB/TrEMBL
    Q68DY7, Q69YM2
    Conserved Domains (3) summary
    COG0513
    Location:1 → 327
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:156 → 291
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:1 → 145
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001320527.2 → NP_001307456.1  ATP-dependent RNA helicase DDX19A isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice junction compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AI863086, AK310604, BC005162, DB074731
    UniProtKB/TrEMBL
    Q59FQ9
    Conserved Domains (3) summary
    COG0513
    Location:34 → 300
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:129 → 264
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:34 → 118
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_018332.5 → NP_060802.1  ATP-dependent RNA helicase DDX19A isoform 1

    See identical proteins and their annotated locations for NP_060802.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI863086, BC005162, DB074731
    Consensus CDS
    CCDS10889.1
    UniProtKB/Swiss-Prot
    B2RPL0, B4DRZ7, Q53FM0, Q9NUU7
    UniProtKB/TrEMBL
    F6QDS0
    Related
    ENSP00000306117.7, ENST00000302243.12
    Conserved Domains (2) summary
    cd18787
    Location:306 → 442
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cl28899
    Location:74 → 302
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RNA

  1. NR_135296.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI863086, AK310804, BC005162, DB074731
    Related
    ENST00000569771.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    70346903..70373383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    76157947..76184410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NUU7.1 GenPept UniProtKB/Swiss-Prot:Q9NUU7

Gene LinkOut

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