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ACOXL acyl-CoA oxidase like [ Homo sapiens (human) ]

Gene ID: 55289, updated on 5-Mar-2024

Summary

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Official Symbol
ACOXLprovided by HGNC
Official Full Name
acyl-CoA oxidase likeprovided by HGNC
Primary source
HGNC:HGNC:25621
See related
Ensembl:ENSG00000153093 AllianceGenome:HGNC:25621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACOX4
Summary
Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Predicted to be located in peroxisomal matrix. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See ACOXL in Genome Data Viewer
Location:
2q13
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (110732573..111118548)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (111155418..111543674)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111490150..111876125)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111434896-111435816 Neighboring gene uncharacterized LOC105373554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111435817-111436737 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111445059-111446030 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111446031-111447002 Neighboring gene Sharpr-MPRA regulatory region 12654 Neighboring gene uncharacterized LOC124906064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16374 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:111510337-111510838 Neighboring gene NANOG hESC enhancer GRCh37_chr2:111529706-111530207 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:111553982-111554181 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:111556532-111557731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111558229-111558834 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:111559681-111560360 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:111570488-111570988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111594132-111595120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16375 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111616831-111617348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111623769-111624474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111624475-111625179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111626664-111627274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:111631628-111632251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111634418-111635282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111661014-111661514 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:111731587-111731774 Neighboring gene NANOG hESC enhancer GRCh37_chr2:111755936-111756510 Neighboring gene ribosomal protein L5 pseudogene 9 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:111789964-111791163 Neighboring gene uncharacterized LOC124907866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16378 Neighboring gene Sharpr-MPRA regulatory region 7769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16380 Neighboring gene ACOXL antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16381 Neighboring gene Sharpr-MPRA regulatory region 8028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11866 Neighboring gene BCL2 like 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:111923374-111923874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16384 Neighboring gene uncharacterized LOC124907868

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism. Van Veldhoven PP. J Lipid Res, 2010 Oct. PMID 20558530, Free PMC Article
  2. Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer. O'Hurley G, et al. PLoS One, 2015. PMID 26237329, Free PMC Article
  3. Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. Lan Q, et al. Eur J Haematol, 2010 Dec. PMID 20731705, Free PMC Article
  4. Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. Slager SL, et al. Blood, 2012 Jul 26. PMID 22700719, Free PMC Article
  5. Genetic susceptibility variants for chronic lymphocytic leukemia. Slager SL, et al. Cancer Epidemiol Biomarkers Prev, 2010 Apr. PMID 20332261, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study identified two proteins, TMEM79 and ACOXL, with potential to differentiate between benign and cancerous prostatic glands in tissue biopsies.
    Title: Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
EBI GWAS Catalog
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
EBI GWAS Catalog
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
EBI GWAS Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
EBI GWAS Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acyl-coenzyme A oxidase-like protein
Names
acyl-CoA oxidase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142807.4 → NP_001136279.1  acyl-coenzyme A oxidase-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023131, AC096591, AC096670, AC114776
    Consensus CDS
    CCDS46389.1
    UniProtKB/Swiss-Prot
    Q9NUZ1
    UniProtKB/TrEMBL
    B4DU63
    Related
    ENSP00000407761.1, ENST00000439055.6
    Conserved Domains (2) summary
    PLN02636
    Location:34 → 545
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2 → 545
    ACAD; Acyl-CoA dehydrogenase

  2. NM_001365487.2 → NP_001352416.1  acyl-coenzyme A oxidase-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC096591, AK300513, BC022268, HY017683
    Consensus CDS
    CCDS92841.1
    Related
    ENSP00000343717.4, ENST00000340561.8
    Conserved Domains (1) summary
    cl09933
    Location:2 → 261
    ACAD; Acyl-CoA dehydrogenase

  3. NM_001371254.1 → NP_001358183.1  acyl-coenzyme A oxidase-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC023131, AC096591, AC096670, AC114776
    Consensus CDS
    CCDS42730.1
    UniProtKB/Swiss-Prot
    A2RRB7, B7WPB3, B7WPP7, E9PB20, Q53R27, Q53R31, Q53SC6, Q8TCE7, Q9NUZ1
    Related
    ENSP00000374461.4, ENST00000389811.8
    Conserved Domains (1) summary
    cl09933
    Location:2 → 544
    ACAD; Acyl-CoA dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    110732573..111118548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511404.4 → XP_011509706.1  acyl-coenzyme A oxidase-like protein isoform X1

    See identical proteins and their annotated locations for XP_011509706.1

    UniProtKB/TrEMBL
    A0A7I2V3X2
    Related
    ENSP00000503683.1, ENST00000676595.2
    Conserved Domains (2) summary
    PLN02636
    Location:34 → 575
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2 → 575
    ACAD; Acyl-CoA dehydrogenase

  2. XM_011511414.4 → XP_011509716.1  acyl-coenzyme A oxidase-like protein isoform X6

    Conserved Domains (1) summary
    cl09933
    Location:2 → 522
    ACAD; Acyl-CoA dehydrogenase

  3. XM_047444905.1 → XP_047300861.1  acyl-coenzyme A oxidase-like protein isoform X9

  4. XM_011511411.4 → XP_011509713.1  acyl-coenzyme A oxidase-like protein isoform X4

    Conserved Domains (1) summary
    cl09933
    Location:2 → 536
    ACAD; Acyl-CoA dehydrogenase

  5. XM_047444903.1 → XP_047300859.1  acyl-coenzyme A oxidase-like protein isoform X8

  6. XM_011511432.4 → XP_011509734.1  acyl-coenzyme A oxidase-like protein isoform X1

    See identical proteins and their annotated locations for XP_011509734.1

    UniProtKB/TrEMBL
    A0A7I2V3X2
    Conserved Domains (2) summary
    PLN02636
    Location:34 → 575
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2 → 575
    ACAD; Acyl-CoA dehydrogenase

  7. XM_047444904.1 → XP_047300860.1  acyl-coenzyme A oxidase-like protein isoform X8

  8. XM_011511413.2 → XP_011509715.1  acyl-coenzyme A oxidase-like protein isoform X5

    Conserved Domains (2) summary
    PLN02636
    Location:34 → 535
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2 → 544
    ACAD; Acyl-CoA dehydrogenase

  9. XM_011511409.2 → XP_011509711.1  acyl-coenzyme A oxidase-like protein isoform X3

    Conserved Domains (2) summary
    PLN02636
    Location:34 → 535
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2 → 546
    ACAD; Acyl-CoA dehydrogenase

  10. XM_011511422.2 → XP_011509724.1  acyl-coenzyme A oxidase-like protein isoform X11

    See identical proteins and their annotated locations for XP_011509724.1

    Conserved Domains (1) summary
    cl09933
    Location:2 → 489
    ACAD; Acyl-CoA dehydrogenase

  11. XM_011511415.3 → XP_011509717.1  acyl-coenzyme A oxidase-like protein isoform X7

    Conserved Domains (2) summary
    PLN02636
    Location:34 → 552
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2 → 544
    ACAD; Acyl-CoA dehydrogenase

  12. XM_011511421.3 → XP_011509723.1  acyl-coenzyme A oxidase-like protein isoform X11

    See identical proteins and their annotated locations for XP_011509723.1

    Conserved Domains (1) summary
    cl09933
    Location:2 → 489
    ACAD; Acyl-CoA dehydrogenase

  13. XM_047444906.1 → XP_047300862.1  acyl-coenzyme A oxidase-like protein isoform X12

  14. XM_011511423.2 → XP_011509725.1  acyl-coenzyme A oxidase-like protein isoform X11

    See identical proteins and their annotated locations for XP_011509725.1

    Conserved Domains (1) summary
    cl09933
    Location:2 → 489
    ACAD; Acyl-CoA dehydrogenase

  15. XM_011511419.3 → XP_011509721.1  acyl-coenzyme A oxidase-like protein isoform X10

    UniProtKB/Swiss-Prot
    Q9NUZ1
    Conserved Domains (2) summary
    PLN02636
    Location:34 → 505
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2 → 514
    ACAD; Acyl-CoA dehydrogenase

  16. XM_047444907.1 → XP_047300863.1  acyl-coenzyme A oxidase-like protein isoform X16

  17. XM_011511427.3 → XP_011509729.1  acyl-coenzyme A oxidase-like protein isoform X13

    Conserved Domains (1) summary
    cl09933
    Location:2 → 486
    ACAD; Acyl-CoA dehydrogenase

  18. XM_011511429.3 → XP_011509731.1  acyl-coenzyme A oxidase-like protein isoform X15

    Conserved Domains (1) summary
    cl09933
    Location:2 → 396
    ACAD; Acyl-CoA dehydrogenase

  19. XM_011511428.4 → XP_011509730.1  acyl-coenzyme A oxidase-like protein isoform X14

    Conserved Domains (1) summary
    cl09933
    Location:2 → 396
    ACAD; Acyl-CoA dehydrogenase

  20. XM_017004431.2 → XP_016859920.1  acyl-coenzyme A oxidase-like protein isoform X17

  21. XM_047444908.1 → XP_047300864.1  acyl-coenzyme A oxidase-like protein isoform X20

  22. XM_017004432.3 → XP_016859921.1  acyl-coenzyme A oxidase-like protein isoform X18

  23. XM_011511405.4 → XP_011509707.1  acyl-coenzyme A oxidase-like protein isoform X1

    See identical proteins and their annotated locations for XP_011509707.1

    UniProtKB/TrEMBL
    A0A7I2V3X2
    Conserved Domains (2) summary
    PLN02636
    Location:34 → 575
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2 → 575
    ACAD; Acyl-CoA dehydrogenase

  24. XM_011511406.4 → XP_011509708.1  acyl-coenzyme A oxidase-like protein isoform X1

    See identical proteins and their annotated locations for XP_011509708.1

    UniProtKB/TrEMBL
    A0A7I2V3X2
    Conserved Domains (2) summary
    PLN02636
    Location:34 → 575
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:2 → 575
    ACAD; Acyl-CoA dehydrogenase

  25. XM_011511407.4 → XP_011509709.1  acyl-coenzyme A oxidase-like protein isoform X2

    Conserved Domains (2) summary
    PLN02636
    Location:30 → 571
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:33 → 571
    ACAD; Acyl-CoA dehydrogenase

  26. XM_017004433.3 → XP_016859922.1  acyl-coenzyme A oxidase-like protein isoform X19

  27. XM_017004434.3 → XP_016859923.1  acyl-coenzyme A oxidase-like protein isoform X21

    Conserved Domains (2) summary
    PLN02636
    Location:1 → 288
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:1 → 288
    ACAD; Acyl-CoA dehydrogenase

  28. XM_011511434.4 → XP_011509736.1  acyl-coenzyme A oxidase-like protein isoform X21

    Conserved Domains (2) summary
    PLN02636
    Location:1 → 288
    PLN02636; acyl-coenzyme A oxidase
    cl09933
    Location:1 → 288
    ACAD; Acyl-CoA dehydrogenase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    111155418..111543674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342808.1 → XP_054198783.1  acyl-coenzyme A oxidase-like protein isoform X8

  2. XM_054342798.1 → XP_054198773.1  acyl-coenzyme A oxidase-like protein isoform X1

  3. XM_054342804.1 → XP_054198779.1  acyl-coenzyme A oxidase-like protein isoform X5

  4. XM_054342802.1 → XP_054198777.1  acyl-coenzyme A oxidase-like protein isoform X3

  5. XM_054342797.1 → XP_054198772.1  acyl-coenzyme A oxidase-like protein isoform X1

  6. XM_054342805.1 → XP_054198780.1  acyl-coenzyme A oxidase-like protein isoform X6

  7. XM_054342809.1 → XP_054198784.1  acyl-coenzyme A oxidase-like protein isoform X9

  8. XM_054342803.1 → XP_054198778.1  acyl-coenzyme A oxidase-like protein isoform X4

  9. XM_054342807.1 → XP_054198782.1  acyl-coenzyme A oxidase-like protein isoform X8

  10. XM_054342811.1 → XP_054198786.1  acyl-coenzyme A oxidase-like protein isoform X11

  11. XM_054342806.1 → XP_054198781.1  acyl-coenzyme A oxidase-like protein isoform X7

  12. XM_054342812.1 → XP_054198787.1  acyl-coenzyme A oxidase-like protein isoform X11

  13. XM_054342814.1 → XP_054198789.1  acyl-coenzyme A oxidase-like protein isoform X12

  14. XM_054342813.1 → XP_054198788.1  acyl-coenzyme A oxidase-like protein isoform X11

  15. XM_054342810.1 → XP_054198785.1  acyl-coenzyme A oxidase-like protein isoform X10

  16. XM_054342818.1 → XP_054198793.1  acyl-coenzyme A oxidase-like protein isoform X16

  17. XM_054342815.1 → XP_054198790.1  acyl-coenzyme A oxidase-like protein isoform X13

  18. XM_054342817.1 → XP_054198792.1  acyl-coenzyme A oxidase-like protein isoform X15

  19. XM_054342816.1 → XP_054198791.1  acyl-coenzyme A oxidase-like protein isoform X14

  20. XM_054342819.1 → XP_054198794.1  acyl-coenzyme A oxidase-like protein isoform X17

  21. XM_054342822.1 → XP_054198797.1  acyl-coenzyme A oxidase-like protein isoform X20

  22. XM_054342820.1 → XP_054198795.1  acyl-coenzyme A oxidase-like protein isoform X18

  23. XM_054342799.1 → XP_054198774.1  acyl-coenzyme A oxidase-like protein isoform X1

  24. XM_054342800.1 → XP_054198775.1  acyl-coenzyme A oxidase-like protein isoform X1

  25. XM_054342801.1 → XP_054198776.1  acyl-coenzyme A oxidase-like protein isoform X2

  26. XM_054342821.1 → XP_054198796.1  acyl-coenzyme A oxidase-like protein isoform X19

  27. XM_054342823.1 → XP_054198798.1  acyl-coenzyme A oxidase-like protein isoform X22

  28. XM_054342824.1 → XP_054198799.1  acyl-coenzyme A oxidase-like protein isoform X21

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105516.2: Suppressed sequence

    Description
    NM_001105516.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_001142808.1: Suppressed sequence

    Description
    NM_001142808.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  3. NM_018308.1: Suppressed sequence

    Description
    NM_018308.1: This RefSeq was permanently suppressed because the CDS was partial.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NUZ1.3 GenPept UniProtKB/Swiss-Prot:Q9NUZ1

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