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SLC47A1 solute carrier family 47 member 1 [ Homo sapiens (human) ]

Gene ID: 55244, updated on 5-Mar-2024

Summary

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Official Symbol
SLC47A1provided by HGNC
Official Full Name
solute carrier family 47 member 1provided by HGNC
Primary source
HGNC:HGNC:25588
See related
Ensembl:ENSG00000142494 MIM:609832; AllianceGenome:HGNC:25588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MATE1
Summary
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 59.0), kidney (RPKM 50.0) and 6 other tissues See more
Orthologs
all
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Genomic context

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See SLC47A1 in Genome Data Viewer
Location:
17p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (19533854..19579034)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (19482011..19527180)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19437167..19482347)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 43 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:19408793-19409392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19413581-19414202 Neighboring gene tRNA-Trp (anticodon CCA) 2-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:19422139-19422858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19455640-19456140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19456141-19456641 Neighboring gene uncharacterized LOC105371578 Neighboring gene small nucleolar RNA, H/ACA box 59B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:19479135-19479710 Neighboring gene SLC47A1 pseudogene 1 Neighboring gene MT-ND1 pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The association study between changes in HbA1C with rs2250486 and rs67238751 genetic variants for SLC47A1 in newly diagnosed Iranian patients with type 2 diabetes mellitus: 6 months follow-up study. Semnani A, et al. Endocrinol Diabetes Metab, 2023 May. PMID 36786075, Free PMC Article
  2. Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO). Gessner A, et al. Sci Rep, 2018 Apr 27. PMID 29704007, Free PMC Article
  3. Relationship between DNA Methylation in the 5' CpG Island of the SLC47A1 (Multidrug and Toxin Extrusion Protein MATE1) Gene and Interindividual Variability in MATE1 Expression in the Human Liver. Tanaka T, et al. Mol Pharmacol, 2018 Jan. PMID 29070695
  4. MATE1 regulates cellular uptake and sensitivity to imatinib in CML patients. Harrach S, et al. Blood Cancer J, 2016 Sep 16. PMID 27635733, Free PMC Article
  5. Lack of Influence of Substrate on Ligand Interaction with the Human Multidrug and Toxin Extruder, MATE1. Martínez-Guerrero LJ, et al. Mol Pharmacol, 2016 Sep. PMID 27418674, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The association study between changes in HbA1C with rs2250486 and rs67238751 genetic variants for SLC47A1 in newly diagnosed Iranian patients with type 2 diabetes mellitus: 6 months follow-up study.
    Title: The association study between changes in HbA1C with rs2250486 and rs67238751 genetic variants for SLC47A1 in newly diagnosed Iranian patients with type 2 diabetes mellitus: 6 months follow-up study.
  2. The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.
    Title: The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.
  3. Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells.
    Title: Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells.
  4. Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.
    Title: Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.
  5. Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing
    Title: Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.
  6. The present data suggest that MATE1 contributes to renal elimination of trimethylamine-N-oxide.
    Title: Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO).
  7. The studied SLC47A1 and SLC47A2 SNPs had no influence on the dose requirement or adverse effects of metformin.
    Title: Lack of effect of the SLC47A1 and SLC47A2 gene polymorphisms on the glycemic response to metformin in type 2 diabetes mellitus patients.
  8. genetic association studies in population in China: Data confirm that an SNP in an intron of SLC47A1 (rs2289669) is associated with hypoglycemic response to metformin in patients with newly diagnosed type 2 diabetes; differential increases in basal GLP1 plasma levels are also related to this SNP. (SLC47A1 = solute carrier family 47 member 1; GLP1 = glucagon-like peptide-1)
    Title: Differential increments of basal glucagon-like-1 peptide concentration among SLC47A1 rs2289669 genotypes were associated with inter-individual variability in glycaemic response to metformin in Chinese people with newly diagnosed Type 2 diabetes.
  9. The impact of assay conditions on IC50 determination is negligible, kinetic characteristics differ among used test substrates, and substrate-dependent inhibition exists for MATE1 and MATE2-K, giving valuable insight into the assessment of clinically relevant MATE-mediated drug interactions in vitro.
    Title: Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs.
  10. Pazopanib inhibits OCT2, MATE1 and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity.
    Title: Inhibition of OCT2, MATE1 and MATE2-K as a possible mechanism of drug interaction between pazopanib and cisplatin.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10847, MGC64822

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-arginine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic cation transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polyspecific organic cation:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables putrescine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thiamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity TAS
Traceable Author Statement
more info
  
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xenobiotic transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-arginine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-arginine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic cation transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in putrescine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thiamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
multidrug and toxin extrusion protein 1
Names
MATE-1
hMATE-1
multidrug and toxin extrusion 1
solute carrier family 47 (multidrug and toxin extrusion), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018242.3 → NP_060712.2  multidrug and toxin extrusion protein 1

    See identical proteins and their annotated locations for NP_060712.2

    Status: VALIDATED

    Source sequence(s)
    AC025627
    Consensus CDS
    CCDS11209.1
    UniProtKB/Swiss-Prot
    Q53HF5, Q6PD77, Q86VL4, Q96FL8, Q9NVA3
    Related
    ENSP00000270570.4, ENST00000270570.8
    Conserved Domains (1) summary
    cd13132
    Location:34 → 468
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    19533854..19579034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    19482011..19527180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FL8.1 GenPept UniProtKB/Swiss-Prot:Q96FL8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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