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SLC38A7 solute carrier family 38 member 7 [ Homo sapiens (human) ]

Gene ID: 55238, updated on 11-Apr-2024

Summary

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Official Symbol
SLC38A7provided by HGNC
Official Full Name
solute carrier family 38 member 7provided by HGNC
Primary source
HGNC:HGNC:25582
See related
Ensembl:ENSG00000103042 MIM:614236; AllianceGenome:HGNC:25582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNAT7
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and sodium ion transport. Predicted to be located in axon and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 12.2), brain (RPKM 4.6) and 23 other tissues See more
Orthologs
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Genomic context

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See SLC38A7 in Genome Data Viewer
Location:
16q21
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (58665109..58684770, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (64457615..64477277, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58699013..58718674, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 1 Neighboring gene transmembrane protein 254-like Neighboring gene uncharacterized LOC124903804 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58662807-58663483 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58663484-58664159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58718046-58718890 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:58732240-58732406 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:58733934-58734162 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:58751959-58753158 Neighboring gene Sharpr-MPRA regulatory region 2773 Neighboring gene glutamic-oxaloacetic transaminase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7556 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58767947-58768565 Neighboring gene RNA, U6 small nuclear 1155, pseudogene Neighboring gene RNY5 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of SLC38A7 as a Prognostic Marker and Potential Therapeutic Target of Lung Squamous Cell Carcinoma. Haratake N, et al. Ann Surg, 2021 Sep 1. PMID 34171866
  2. Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2. Dudenkov TM, et al. Clin Pharmacol Ther, 2019 Jul. PMID 30648747, Free PMC Article
  3. SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells. Verdon Q, et al. Proc Natl Acad Sci U S A, 2017 May 2. PMID 28416685, Free PMC Article
  4. Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. Hägglund MG, et al. J Biol Chem, 2011 Jun 10. PMID 21511949, Free PMC Article
  5. SNAT7 regulates mTORC1 via macropinocytosis. Meng D, et al. Proc Natl Acad Sci U S A, 2022 May 17. PMID 35561222, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNAT7 regulates mTORC1 via macropinocytosis.
    Title: SNAT7 regulates mTORC1 via macropinocytosis.
  2. Identification of SLC38A7 as a Prognostic Marker and Potential Therapeutic Target of Lung Squamous Cell Carcinoma.
    Title: Identification of SLC38A7 as a Prognostic Marker and Potential Therapeutic Target of Lung Squamous Cell Carcinoma.
  3. GWAS identified a novel gene encoding an anastrozole transporter, SLC38A7, as well as epistatic interaction between SNPs in that gene and SNPs near ALPPL2 that influenced both the expression of the transporter and anastrozole plasma concentrations
    Title: Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2.
  4. Cell fractionation confirmed the lysosomal localization of SNAT7, and flux measurements confirmed its substrate selectivity and showed a strong activation by the lysosomal pH gradient. Interestingly, gene silencing or editing experiments revealed that SNAT7 is the primary permeation pathway for glutamine across the lysosomal membrane and it is required for growth of cancer cells in a low free-glutamine environment.
    Title: SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Common variants at ten loci influence QT interval duration in the QTGEN Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10815, FLJ12724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-asparagine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-asparagine:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamine:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-glutamine:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparagine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutamine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutamine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sodium-coupled neutral amino acid transporter 7
Names
Sodium-coupled neutral amino acid transporter 7
amino acid transporter
putative sodium-coupled neutral amino acid transporter 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308384.2 → NP_001295313.1  sodium-coupled neutral amino acid transporter 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS76883.1
    UniProtKB/TrEMBL
    H3BMC5
    Related
    ENSP00000454325.1, ENST00000564100.5
    Conserved Domains (1) summary
    cl00456
    Location:49 → 301
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001369608.1 → NP_001356537.1  sodium-coupled neutral amino acid transporter 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS10800.1
    UniProtKB/Swiss-Prot
    Q53GJ9, Q9H9I5, Q9NVC3
    UniProtKB/TrEMBL
    H3BPK8
    Conserved Domains (1) summary
    cl00456
    Location:49 → 457
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_001369609.1 → NP_001356538.1  sodium-coupled neutral amino acid transporter 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS10800.1
    UniProtKB/Swiss-Prot
    Q53GJ9, Q9H9I5, Q9NVC3
    UniProtKB/TrEMBL
    H3BPK8
    Conserved Domains (1) summary
    cl00456
    Location:49 → 457
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_001369610.1 → NP_001356539.1  sodium-coupled neutral amino acid transporter 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS76883.1
    UniProtKB/TrEMBL
    H3BMC5
    Conserved Domains (1) summary
    cl00456
    Location:49 → 301
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. NM_001369611.1 → NP_001356540.1  sodium-coupled neutral amino acid transporter 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010287
    Consensus CDS
    CCDS10800.1
    UniProtKB/Swiss-Prot
    Q53GJ9, Q9H9I5, Q9NVC3
    UniProtKB/TrEMBL
    H3BPK8
    Related
    ENSP00000454646.1, ENST00000570101.5
    Conserved Domains (1) summary
    cl00456
    Location:49 → 457
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. NM_018231.3 → NP_060701.1  sodium-coupled neutral amino acid transporter 7 isoform 1

    See identical proteins and their annotated locations for NP_060701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC010287, AK001677
    Consensus CDS
    CCDS10800.1
    UniProtKB/Swiss-Prot
    Q53GJ9, Q9H9I5, Q9NVC3
    UniProtKB/TrEMBL
    H3BPK8
    Related
    ENSP00000219320.3, ENST00000219320.9
    Conserved Domains (1) summary
    cl00456
    Location:49 → 457
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. NR_161424.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010287

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    58665109..58684770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023396.2 → XP_016878885.1  sodium-coupled neutral amino acid transporter 7 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:49 → 297
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_047434325.1 → XP_047290281.1  sodium-coupled neutral amino acid transporter 7 isoform X1

  3. XM_047434326.1 → XP_047290282.1  sodium-coupled neutral amino acid transporter 7 isoform X3

  4. XM_017023398.3 → XP_016878887.1  sodium-coupled neutral amino acid transporter 7 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:49 → 295
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  5. XM_017023399.3 → XP_016878888.1  sodium-coupled neutral amino acid transporter 7 isoform X5

    UniProtKB/TrEMBL
    H3BP25
    Conserved Domains (1) summary
    cl00456
    Location:49 → 220
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. XM_047434328.1 → XP_047290284.1  sodium-coupled neutral amino acid transporter 7 isoform X5

  7. XM_047434327.1 → XP_047290283.1  sodium-coupled neutral amino acid transporter 7 isoform X4

    Related
    ENSP00000455119.1, ENST00000566598.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    64457615..64477277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380649.1 → XP_054236624.1  sodium-coupled neutral amino acid transporter 7 isoform X1

  2. XM_054380648.1 → XP_054236623.1  sodium-coupled neutral amino acid transporter 7 isoform X1

  3. XM_054380651.1 → XP_054236626.1  sodium-coupled neutral amino acid transporter 7 isoform X3

  4. XM_054380650.1 → XP_054236625.1  sodium-coupled neutral amino acid transporter 7 isoform X2

  5. XM_054380654.1 → XP_054236629.1  sodium-coupled neutral amino acid transporter 7 isoform X5

  6. XM_054380653.1 → XP_054236628.1  sodium-coupled neutral amino acid transporter 7 isoform X5

  7. XM_054380652.1 → XP_054236627.1  sodium-coupled neutral amino acid transporter 7 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NVC3.1 GenPept UniProtKB/Swiss-Prot:Q9NVC3

Gene LinkOut

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