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LRRC1 leucine rich repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 55227, updated on 11-Apr-2024

Summary

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Official Symbol
LRRC1provided by HGNC
Official Full Name
leucine rich repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:14307
See related
Ensembl:ENSG00000137269 MIM:608195; AllianceGenome:HGNC:14307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LANO; dJ523E19.1
Summary
Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon (RPKM 4.5), thyroid (RPKM 3.0) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
6p12.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (53795005..53924125)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (53634953..53764073)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (53659803..53788923)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24700 Neighboring gene Sharpr-MPRA regulatory region 11274 Neighboring gene kelch like family member 31 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:53587553-53587738 Neighboring gene uncharacterized LOC124901334 Neighboring gene NANOG hESC enhancer GRCh37_chr6:53595032-53595549 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:53599001-53600200 Neighboring gene uncharacterized LOC124901333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17294 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:53659875-53660587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17295 Neighboring gene Sharpr-MPRA regulatory region 10889 Neighboring gene Sharpr-MPRA regulatory region 6720 Neighboring gene uncharacterized LOC101927189 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:53810369-53810988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:53810989-53811607 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:53826656-53827156 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:53841998-53842202 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:53848425-53849624 Neighboring gene MLIP intronic transcript 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The downstream PPARγ target LRRC1 participates in early stage adipocytic differentiation. Wang X, et al. Mol Cell Biochem, 2023 Jul. PMID 36370237, Free PMC Article
  2. Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1. Wu H, et al. Cell Death Dis, 2020 Sep 25. PMID 32978367, Free PMC Article
  3. The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling. Lopez Almeida L, et al. Stem Cell Reports, 2018 Nov 13. PMID 30344009, Free PMC Article
  4. Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma. Li Y, et al. Mol Biol Rep, 2013 Jul. PMID 23645086
  5. The Tumor Suppressor SCRIB is a Negative Modulator of the Wnt/β-Catenin Signaling Pathway. Daulat AM, et al. Proteomics, 2019 Nov. PMID 31513346

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
    Title: The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
  2. LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating beta-catenin/c-Myc signaling.
    Title: LRRC1 knockdown downregulates MACF1 to inhibit the malignant progression of acute myeloid leukemia by inactivating β-catenin/c-Myc signaling.
  3. The downstream PPARgamma target LRRC1 participates in early stage adipocytic differentiation.
    Title: The downstream PPARγ target LRRC1 participates in early stage adipocytic differentiation.
  4. Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1.
    Title: Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1.
  5. Common and specific sets of proteins associated to SCRIB and LANO by MS are identified and an extensive landscape of their associated networks and the first comparative analysis of their respective interactomes are provided
    Title: The Tumor Suppressor SCRIB is a Negative Modulator of the Wnt/β-Catenin Signaling Pathway.
  6. Lano/LRRC1-depleted cells secrete increased levels of WNT ligands.
    Title: The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling.
  7. LRRC1 contributes to HCC development, and may be a potential target for therapeutic intervention in this disease.
    Title: Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10775, FLJ11834

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 1
Names
LANO adapter protein
LAP (leucine-rich repeats and PDZ) and no PDZ protein
LAP and no PDZ protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018214.5 → NP_060684.4  leucine-rich repeat-containing protein 1

    See identical proteins and their annotated locations for NP_060684.4

    Status: VALIDATED

    Source sequence(s)
    AL033384, BC003193
    Consensus CDS
    CCDS4953.2
    UniProtKB/Swiss-Prot
    Q5TGN3, Q9BTT6, Q9HAC0, Q9NVF1
    UniProtKB/TrEMBL
    A8K883
    Related
    ENSP00000359925.1, ENST00000370888.6
    Conserved Domains (3) summary
    cd00116
    Location:33 → 232
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:61 → 83
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:129 → 186
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    53795005..53924125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010997.2 → XP_016866486.1  leucine-rich repeat-containing protein 1 isoform X2

  2. XM_011514727.3 → XP_011513029.1  leucine-rich repeat-containing protein 1 isoform X1

    Conserved Domains (2) summary
    sd00033
    Location:48 → 70
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:70 → 127
    LRR_8; Leucine rich repeat

RNA

  1. XR_007059279.1 RNA Sequence

  2. XR_001743505.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    53634953..53764073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355779.1 → XP_054211754.1  leucine-rich repeat-containing protein 1 isoform X2

  2. XM_054355778.1 → XP_054211753.1  leucine-rich repeat-containing protein 1 isoform X1

RNA

  1. XR_008487363.1 RNA Sequence

  2. XR_008487364.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025168.1: Suppressed sequence

    Description
    NM_025168.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BTT6.1 GenPept UniProtKB/Swiss-Prot:Q9BTT6

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