Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Tat
|
tat
|
HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells |
PubMed
|
|
tat
|
Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 |
PubMed
|
|
tat
|
An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues |
PubMed
|
|
vpr
|
HIV-1 Vpr was found to upregulate PP2A in fission yeast |
PubMed
|
|
vpr
|
HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A |
PubMed
|
nucleocapsid
|
gag
|
HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A |
PubMed
|
Go to the HIV-1, Human Interaction Database