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ARHGAP17 Rho GTPase activating protein 17 [ Homo sapiens (human) ]

Gene ID: 55114, updated on 3-Apr-2024

Summary

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Official Symbol
ARHGAP17provided by HGNC
Official Full Name
Rho GTPase activating protein 17provided by HGNC
Primary source
HGNC:HGNC:18239
See related
Ensembl:ENSG00000140750 MIM:608293; AllianceGenome:HGNC:18239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP367; RICH1; WBP15; MST066; MST110; NADRIN; PP4534; RICH-1; MSTP038; MSTP066; MSTP110
Summary
RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in spleen (RPKM 24.3), lymph node (RPKM 19.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p12.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (24919389..25015369, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (25199011..25294991, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (24930710..25026690, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing adaptor 6A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10600 Neighboring gene long intergenic non-protein coding RNA 1567 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:24695075-24695665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:24697561-24698060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:24834133-24834633 Neighboring gene Sharpr-MPRA regulatory region 7462 Neighboring gene solute carrier family 5 member 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:24917770-24918270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:24999769-25000372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10601 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25025578-25026246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25026247-25026915 Neighboring gene thyroid hormone receptor interactor 11 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:25033996-25034167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10602 Neighboring gene leucine carboxyl methyltransferase 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42. Wang L, et al. Clin Exp Pharmacol Physiol, 2020 Sep. PMID 32391922
  2. Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/β-Catenin Signaling. Pan S, et al. Cell Physiol Biochem, 2018. PMID 29730655
  3. ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia. Kreider-Letterman G, et al. J Cell Biol, 2023 Feb 6. PMID 36571786, Free PMC Article
  4. ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer cells by suppressing Rac1. Pan SL, et al. Neoplasma, 2022 May. PMID 35293764
  5. Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets. Nagy Z, et al. J Biol Chem, 2015 Dec 11. PMID 26507661, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia.
    Title: ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia.
  2. ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer cells by suppressing Rac1.
    Title: ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer cells by suppressing Rac1.
  3. ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42.
    Title: ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42.
  4. ARHGAP17 functions as a tumor suppressor in cervical cancer that suppresses tumor growth, at least partly, through inhibition of PI3K/AKT signaling and up-regulation of P21 and P27 expression.
    Title: ARHGAP17 suppresses tumor progression and up-regulates P21 and P27 expression via inhibiting PI3K/AKT signaling pathway in cervical cancer.
  5. The bevacizumab-independent VEGF/NRP1/ARHGAP17/Cdc42 regulatory network plays important roles in malignant behavior of breast cancer.
    Title: Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network.
  6. In vitro analysis demonstrated that ARHGAP17 overexpression inhibited cell growth and invasion of HCT-8 and HCT-116 cells.
    Title: Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/β-Catenin Signaling.
  7. show that ARHGAP17 binds to the actin-regulating CIP4 protein in platelets and that Ser-702 phosphorylation interferes with this interaction
    Title: Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.
  8. Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway.
    Title: Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. We propose that Rich1 and Amot maintain TJ integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking.
    Title: A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37567, FLJ43368, MGC87805, DKFZp564A1363

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-ion regulated exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 17
Names
RhoGAP interacting with CIP4 homologs 1
neuron-associated developmentally regulated protein
rho-type GTPase-activating protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006634.3 → NP_001006635.1  rho GTPase-activating protein 17 isoform 1

    See identical proteins and their annotated locations for NP_001006635.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC080195, BU187683
    Consensus CDS
    CCDS32409.1
    UniProtKB/Swiss-Prot
    A8K6M6, Q68EM7, Q6ZUS4, Q7Z2F2, Q8NDG2, Q96KS2, Q96KS3, Q96SS8, Q9BVF6, Q9H8U5, Q9NW54
    UniProtKB/TrEMBL
    A0A2X0SF71
    Related
    ENSP00000289968.6, ENST00000289968.11
    Conserved Domains (4) summary
    cd07618
    Location:13 → 257
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    PRK14951
    Location:522 → 631
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd04386
    Location:246 → 446
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
    pfam09770
    Location:536 → 739
    PAT1; Topoisomerase II-associated protein PAT1

  2. NM_018054.6 → NP_060524.4  rho GTPase-activating protein 17 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC080195, BU187683
    Consensus CDS
    CCDS32408.1
    UniProtKB/TrEMBL
    A0A2X0SF71
    Related
    ENSP00000303130.5, ENST00000303665.9
    Conserved Domains (2) summary
    cd07618
    Location:13 → 257
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:246 → 446
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    24919389..25015369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434318.1 → XP_047290274.1  rho GTPase-activating protein 17 isoform X12

  2. XM_047434314.1 → XP_047290270.1  rho GTPase-activating protein 17 isoform X7

  3. XM_047434313.1 → XP_047290269.1  rho GTPase-activating protein 17 isoform X6

  4. XM_011545878.4 → XP_011544180.1  rho GTPase-activating protein 17 isoform X9

    UniProtKB/TrEMBL
    A0A2X0SF71
    Conserved Domains (2) summary
    cd07618
    Location:13 → 289
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:278 → 478
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

  5. XM_047434316.1 → XP_047290272.1  rho GTPase-activating protein 17 isoform X10

  6. XM_011545873.4 → XP_011544175.1  rho GTPase-activating protein 17 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SF71
    Conserved Domains (2) summary
    cd07618
    Location:13 → 289
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:278 → 478
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

  7. XM_011545876.3 → XP_011544178.1  rho GTPase-activating protein 17 isoform X5

    UniProtKB/TrEMBL
    A0A2X0SF71
    Conserved Domains (2) summary
    cd07618
    Location:13 → 289
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:278 → 478
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

  8. XM_011545875.3 → XP_011544177.1  rho GTPase-activating protein 17 isoform X3

    UniProtKB/TrEMBL
    A0A2X0SF71
    Conserved Domains (2) summary
    cd07618
    Location:13 → 289
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:278 → 478
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

  9. XM_047434315.1 → XP_047290271.1  rho GTPase-activating protein 17 isoform X8

  10. XM_047434311.1 → XP_047290267.1  rho GTPase-activating protein 17 isoform X2

  11. XM_047434312.1 → XP_047290268.1  rho GTPase-activating protein 17 isoform X4

  12. XM_047434317.1 → XP_047290273.1  rho GTPase-activating protein 17 isoform X11

  13. XM_047434319.1 → XP_047290275.1  rho GTPase-activating protein 17 isoform X13

  14. XM_047434320.1 → XP_047290276.1  rho GTPase-activating protein 17 isoform X14

  15. XM_047434322.1 → XP_047290278.1  rho GTPase-activating protein 17 isoform X16

  16. XM_047434321.1 → XP_047290277.1  rho GTPase-activating protein 17 isoform X15

RNA

  1. XR_950809.3 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160019.1 Reference GRCh38.p14 PATCHES

    Range
    172872..268852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332642.1 → XP_054188617.1  rho GTPase-activating protein 17 isoform X12

  2. XM_054332637.1 → XP_054188612.1  rho GTPase-activating protein 17 isoform X7

  3. XM_054332636.1 → XP_054188611.1  rho GTPase-activating protein 17 isoform X6

  4. XM_054332639.1 → XP_054188614.1  rho GTPase-activating protein 17 isoform X9

  5. XM_054332640.1 → XP_054188615.1  rho GTPase-activating protein 17 isoform X10

  6. XM_054332631.1 → XP_054188606.1  rho GTPase-activating protein 17 isoform X1

  7. XM_054332635.1 → XP_054188610.1  rho GTPase-activating protein 17 isoform X5

  8. XM_054332633.1 → XP_054188608.1  rho GTPase-activating protein 17 isoform X3

  9. XM_054332638.1 → XP_054188613.1  rho GTPase-activating protein 17 isoform X8

  10. XM_054332632.1 → XP_054188607.1  rho GTPase-activating protein 17 isoform X2

  11. XM_054332634.1 → XP_054188609.1  rho GTPase-activating protein 17 isoform X4

  12. XM_054332641.1 → XP_054188616.1  rho GTPase-activating protein 17 isoform X11

  13. XM_054332643.1 → XP_054188618.1  rho GTPase-activating protein 17 isoform X13

  14. XM_054332644.1 → XP_054188619.1  rho GTPase-activating protein 17 isoform X14

  15. XM_054332646.1 → XP_054188621.1  rho GTPase-activating protein 17 isoform X16

  16. XM_054332645.1 → XP_054188620.1  rho GTPase-activating protein 17 isoform X15

RNA

  1. XR_008485785.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    25199011..25294991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380637.1 → XP_054236612.1  rho GTPase-activating protein 17 isoform X12

  2. XM_054380632.1 → XP_054236607.1  rho GTPase-activating protein 17 isoform X7

  3. XM_054380631.1 → XP_054236606.1  rho GTPase-activating protein 17 isoform X6

  4. XM_054380634.1 → XP_054236609.1  rho GTPase-activating protein 17 isoform X9

  5. XM_054380635.1 → XP_054236610.1  rho GTPase-activating protein 17 isoform X10

  6. XM_054380626.1 → XP_054236601.1  rho GTPase-activating protein 17 isoform X1

  7. XM_054380630.1 → XP_054236605.1  rho GTPase-activating protein 17 isoform X5

  8. XM_054380628.1 → XP_054236603.1  rho GTPase-activating protein 17 isoform X3

  9. XM_054380633.1 → XP_054236608.1  rho GTPase-activating protein 17 isoform X8

  10. XM_054380627.1 → XP_054236602.1  rho GTPase-activating protein 17 isoform X2

  11. XM_054380629.1 → XP_054236604.1  rho GTPase-activating protein 17 isoform X4

  12. XM_054380636.1 → XP_054236611.1  rho GTPase-activating protein 17 isoform X11

  13. XM_054380638.1 → XP_054236613.1  rho GTPase-activating protein 17 isoform X13

  14. XM_054380639.1 → XP_054236614.1  rho GTPase-activating protein 17 isoform X14

  15. XM_054380641.1 → XP_054236616.1  rho GTPase-activating protein 17 isoform X16

  16. XM_054380640.1 → XP_054236615.1  rho GTPase-activating protein 17 isoform X15

RNA

  1. XR_008489101.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68EM7.1 GenPept UniProtKB/Swiss-Prot:Q68EM7

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