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PPP1R7 protein phosphatase 1 regulatory subunit 7 [ Homo sapiens (human) ]

Gene ID: 5510, updated on 5-May-2024

Summary

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Official Symbol
PPP1R7provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 7provided by HGNC
Primary source
HGNC:HGNC:9295
See related
Ensembl:ENSG00000115685 MIM:602877; AllianceGenome:HGNC:9295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDS22
Summary
This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Broad expression in testis (RPKM 40.9), brain (RPKM 18.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q37.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241149573..241183652)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241648673..241683461)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242088988..242123067)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241949545-241950150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241950151-241950754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241957354-241957854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241957855-241958355 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57691 Neighboring gene SNED1 antisense RNA 1 Neighboring gene sushi, nidogen and EGF like domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241973517-241974460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241974461-241975402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241975403-241976346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12526 Neighboring gene mitochondrial transcription termination factor 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242012857-242013373 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242040949-242041488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242041489-242042028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17415 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57723 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57727 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242079269-242079769 Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242097726-242098226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:242106157-242106656 Neighboring gene uncharacterized LOC105373971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242125644-242126166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242127362-242128046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242128047-242128730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242129664-242130164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242130165-242130665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242152515-242153074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242155713-242156244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17420 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_57796 Neighboring gene anoctamin 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242163435-242164395 Neighboring gene uncharacterized LOC105376810 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242175313-242175524 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242189957-242190163 Neighboring gene high density lipoprotein binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12534 Neighboring gene HDLBP antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway. Paul D, et al. Neoplasia, 2019 Jan. PMID 30500680, Free PMC Article
  2. Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis. Posch M, et al. J Cell Biol, 2010 Oct 4. PMID 20921135, Free PMC Article
  3. SDS22 selectively recognizes and traps metal-deficient inactive PP1. Choy MS, et al. Proc Natl Acad Sci U S A, 2019 Oct 8. PMID 31548429, Free PMC Article
  4. Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1. Heroes E, et al. Structure, 2019 Mar 5. PMID 30661852, Free PMC Article
  5. Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation. Duan H, et al. J Biol Chem, 2016 Sep 30. PMID 27557660, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and biochemical studies revealed that the concave side of SDS22 likely interacts with PP1 helices alpha5 and alpha6, which are distal from the binding sites of many previously described PP1 interactors. Accordingly, SDS22 would act as a "third" subunit of multiple PP1 holoenzymes. The crystal structure of SDS22 also revealed a large basic surface patch that enables binding of a phosphorylated form of BCLAF1.
    Title: Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.
  2. Ppp1r7 may play a central role in regulating the PP1 interactome by acting as a competitive molecular "sponge" of PP1c.
    Title: Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.
  3. our findings revealed that protein phosphatase regulatory subunit SDS22 functions as a putative tumor suppressor by dephosphorylation-mediated inactivation of AKT and MAPK signaling pathways.
    Title: Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway.
  4. a Fra-1-miR-134 axis drives a positive feedback loop that amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells.
    Title: The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells.
  5. Mechanistically, the phosphorylation of Sds22 by PLK1 strengthens the binding of Sds22 to PP1 and inhibits the dephosphorylation of Thr(232) of Aurora B to ensure a robust, error-free metaphase-anaphase transition.
    Title: Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation.
  6. there is a second, parallel signalling pathway which triggers the relaxation of the polar cell cortex at mid anaphase--independent of furrow formation, centrosomes and microtubules, pathway depends on PP1 phosphatase and regulatory subunit Sds22
    Title: Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation.
  7. a model in which I3 regulates an SDS22-mediated PP1 activation step in solution that precedes SDS22 dissociation and transfer of PP1 to kinetochores, and which is required for PP1 to efficiently antagonize Aurora B.
    Title: Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1.
  8. It was shown that Repo-Man and Sds22 contribute to timely Aurora B kinase substrate dephosphorylation on anaphase chromatin.
    Title: Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.
  9. human Sds22 is focally deleted and downregulated in multiple carcinomas, and this downregulation correlates with tumor progression, suggesting that sds22 inactivation may contribute to tumorigenesis and metastatic potential
    Title: Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling.
  10. Sds22 specifically defines protein phosphatase 1 function and localization in mitosis.
    Title: Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme regulator activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 7
Names
protein phosphatase 1 regulatory subunit 22
protein phosphatase 1, regulatory (inhibitor) subunit 7
testis secretory sperm-binding protein Li 210a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282409.1 → NP_001269338.1  protein phosphatase 1 regulatory subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001269338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 2, also known as sds22alpha2) is shorter compared to isoform 1.
    Source sequence(s)
    AC005237, BC051689, BM676947
    Consensus CDS
    CCDS63194.1
    UniProtKB/TrEMBL
    C9J177
    Related
    ENSP00000272983.8, ENST00000272983.12
    Conserved Domains (3) summary
    smart00446
    Location:293 → 311
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:57 → 78
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:44 → 274
    internalin_A; class 1 internalin InlA

  2. NM_001282410.1 → NP_001269339.1  protein phosphatase 1 regulatory subunit 7 isoform 3

    See identical proteins and their annotated locations for NP_001269339.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded protein (isoform 3, also known as sds22beta1) is shorter compared to isoform 1.
    Source sequence(s)
    AC005237, BC013001, BC051689
    Consensus CDS
    CCDS63192.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000385022.3, ENST00000406106.7
    Conserved Domains (2) summary
    COG4886
    Location:108 → 272
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:100 → 121
    LRR_RI; leucine-rich repeat [structural motif]

  3. NM_001282411.1 → NP_001269340.1  protein phosphatase 1 regulatory subunit 7 isoform 4

    See identical proteins and their annotated locations for NP_001269340.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks alternate exons in the coding region and uses an alternate 3' terminal exon compared to variant 1. The encoded protein (isoform 4, also known as sds22beta2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC005237, BC013001, BC051689, BG684153
    Consensus CDS
    CCDS63193.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000385466.1, ENST00000401987.5
    Conserved Domains (3) summary
    sd00033
    Location:57 → 78
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:165 → 207
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:165 → 221
    LRR_8; Leucine rich repeat

  4. NM_001282412.1 → NP_001269341.1  protein phosphatase 1 regulatory subunit 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 5) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC005237, AK308015, BC000910, BM676947, DA787059
    UniProtKB/TrEMBL
    H7C003
    Related
    ENSP00000392373.1, ENST00000450367.1
    Conserved Domains (3) summary
    sd00033
    Location:84 → 105
    LRR_RI; leucine-rich repeat [structural motif]
    NF033188
    Location:65 → 227
    internalin_H; InlH/InlC2 family class 1 internalin
    cd21340
    Location:147 → 338
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  5. NM_001282413.1 → NP_001269342.1  protein phosphatase 1 regulatory subunit 7 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' structure, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 6) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC005237, AK308015, BC000910, BI256145, BM676947, DA787059
    UniProtKB/TrEMBL
    C9J177
    Related
    ENSP00000412092.1, ENST00000423280.5
    Conserved Domains (3) summary
    sd00033
    Location:41 → 62
    LRR_RI; leucine-rich repeat [structural motif]
    NF033188
    Location:22 → 184
    internalin_H; InlH/InlC2 family class 1 internalin
    cd21340
    Location:104 → 295
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  6. NM_001282414.1 → NP_001269343.1  protein phosphatase 1 regulatory subunit 7 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and has multiple coding region differences compared to variant 1. The encoded protein (isoform 7) is shorter and has distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC005237, BC013001, BQ212238, DA787059
    Consensus CDS
    CCDS63190.1
    UniProtKB/Swiss-Prot
    Q15435
    Related
    ENSP00000385012.1, ENST00000402734.5
    Conserved Domains (2) summary
    sd00033
    Location:41 → 62
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:38 → 213
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  7. NM_002712.3 → NP_002703.1  protein phosphatase 1 regulatory subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_002703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as sds22alpha1).
    Source sequence(s)
    AC005237, BC000910, BC051689, BM676947
    Consensus CDS
    CCDS2546.1
    UniProtKB/Swiss-Prot
    B4DFD4, B5MCY6, Q15435, Q9UQE5, Q9UQE6, Q9Y6K4
    UniProtKB/TrEMBL
    A0A140VK83, H7C003
    Related
    ENSP00000234038.6, ENST00000234038.11
    Conserved Domains (3) summary
    smart00446
    Location:336 → 354
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:100 → 121
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:87 → 317
    internalin_A; class 1 internalin InlA

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    241149573..241183652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444851.1 → XP_047300807.1  protein phosphatase 1 regulatory subunit 7 isoform X2

    Related
    ENSP00000396376.1, ENST00000438799.5

  2. XM_011511388.3 → XP_011509690.1  protein phosphatase 1 regulatory subunit 7 isoform X1

    UniProtKB/TrEMBL
    C9J177
    Conserved Domains (3) summary
    smart00446
    Location:268 → 286
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:32 → 53
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:19 → 249
    internalin_A; class 1 internalin InlA

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    241648673..241683461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342715.1 → XP_054198690.1  protein phosphatase 1 regulatory subunit 7 isoform X2

  2. XM_054342714.1 → XP_054198689.1  protein phosphatase 1 regulatory subunit 7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15435.1 GenPept UniProtKB/Swiss-Prot:Q15435

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