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TMEM45A transmembrane protein 45A [ Homo sapiens (human) ]

Gene ID: 55076, updated on 5-Mar-2024

Summary

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Official Symbol
TMEM45Aprovided by HGNC
Official Full Name
transmembrane protein 45Aprovided by HGNC
Primary source
HGNC:HGNC:25480
See related
Ensembl:ENSG00000181458 MIM:616928; AllianceGenome:HGNC:25480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DERP7; DNAPTP4
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 215.6), liver (RPKM 25.9) and 2 other tissues See more
Orthologs
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Genomic context

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See TMEM45A in Genome Data Viewer
Location:
3q12.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100492619..100577444)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103198293..103283136)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100211463..100296288)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 70 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100118351-100119270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100126809-100127334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100127335-100127860 Neighboring gene leukemia NUP98 fusion partner 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100170016-100170553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100184868-100185368 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:100195719-100196404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14573 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100280470-100281334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20161 Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20163 Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100427906-100428797 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100428798-100429688 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100456051-100456928 Neighboring gene trafficking from ER to golgi regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TMEM45A Affects Proliferation, Apoptosis, Epithelial-Mesenchymal Transition, Migration, Invasion and Cisplatin Resistance of HPV-Positive Cervical Cancer Cell Lines. Liu Y, et al. Biochem Genet, 2022 Feb. PMID 34143331
  2. Characterization of the role of TMEM45A in cancer cell sensitivity to cisplatin. Schmit K, et al. Cell Death Dis, 2019 Dec 4. PMID 31801939, Free PMC Article
  3. Knockdown of TMEM45A overcomes multidrug resistance and epithelial-mesenchymal transition in human colorectal cancer cells through inhibition of TGF-β signalling pathway. Zhu M, et al. Clin Exp Pharmacol Physiol, 2020 Mar. PMID 31788833
  4. Knockdown of TMEM45A inhibits the proliferation, migration and invasion of glioma cells. Sun W, et al. Int J Clin Exp Pathol, 2015. PMID 26722455, Free PMC Article
  5. High TMEM45A expression is correlated to epidermal keratinization. Hayez A, et al. Exp Dermatol, 2014 May. PMID 24689342

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of Variants in TMEM45A With Keratoglobus.
    Title: Association of Variants in TMEM45A With Keratoglobus.
  2. TMEM45A Affects Proliferation, Apoptosis, Epithelial-Mesenchymal Transition, Migration, Invasion and Cisplatin Resistance of HPV-Positive Cervical Cancer Cell Lines.
    Title: TMEM45A Affects Proliferation, Apoptosis, Epithelial-Mesenchymal Transition, Migration, Invasion and Cisplatin Resistance of HPV-Positive Cervical Cancer Cell Lines.
  3. Transmembrane protein 45A regulates the proliferation, migration, and invasion of glioma cells through nuclear factor kappa-B.
    Title: Transmembrane protein 45A regulates the proliferation, migration, and invasion of glioma cells through nuclear factor kappa-B.
  4. Knockdown of TMEM45A overcomes multidrug resistance and epithelial-mesenchymal transition in human colorectal cancer cells through inhibition of TGF-beta signalling pathway.
    Title: Knockdown of TMEM45A overcomes multidrug resistance and epithelial-mesenchymal transition in human colorectal cancer cells through inhibition of TGF-β signalling pathway.
  5. Characterization of the role of TMEM45A in cancer cell sensitivity to cisplatin.
    Title: Characterization of the role of TMEM45A in cancer cell sensitivity to cisplatin.
  6. our study suggests that TMEM45A may work as an oncogene and a new effective therapeutic target for glioma treatment.
    Title: Knockdown of TMEM45A inhibits the proliferation, migration and invasion of glioma cells.
  7. knockdown of TMEM45A also inhibited cell adhesion as well as cell invasion. More importantly, suppression of TMEM45A notably downregulated the expression of TGF-b1, TGF-b2, RhoA and ROCK2.
    Title: Inhibition of TMEM45A suppresses proliferation, induces cell cycle arrest and reduces cell invasion in human ovarian cancer cells.
  8. TMEM45A expression is correlated to epidermal keratinization
    Title: High TMEM45A expression is correlated to epidermal keratinization.
  9. Data suggest that high levels of TMEM45A expression in tumors may be indicative of potential resistance to cancer therapy, making TMEM45A an interesting biomarker for resistance.
    Title: TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 45A
Names
DNA polymerase-transactivated protein 4
dermal papilla derived protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363876.2 → NP_001350805.1  transmembrane protein 45A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC128693
    Consensus CDS
    CCDS87113.1
    UniProtKB/TrEMBL
    J3KQ06
    Conserved Domains (1) summary
    pfam04819
    Location:139 → 256
    DUF716; Family of unknown function (DUF716)

  2. NM_018004.3 → NP_060474.1  transmembrane protein 45A isoform 2

    See identical proteins and their annotated locations for NP_060474.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC128693, AY450392, BG205309
    Consensus CDS
    CCDS2937.1
    UniProtKB/Swiss-Prot
    Q53YW5, Q9NWC5
    Related
    ENSP00000319009.4, ENST00000323523.8
    Conserved Domains (1) summary
    pfam04819
    Location:123 → 240
    DUF716; Family of unknown function (DUF716)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    100492619..100577444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448425.1 → XP_047304381.1  transmembrane protein 45A isoform X3

    UniProtKB/TrEMBL
    J3KQ06
    Related
    ENSP00000385089.1, ENST00000403410.5

  2. XM_047448427.1 → XP_047304383.1  transmembrane protein 45A isoform X3

    UniProtKB/TrEMBL
    J3KQ06

  3. XM_047448426.1 → XP_047304382.1  transmembrane protein 45A isoform X3

    UniProtKB/TrEMBL
    J3KQ06

  4. XM_047448418.1 → XP_047304374.1  transmembrane protein 45A isoform X1

  5. XM_047448419.1 → XP_047304375.1  transmembrane protein 45A isoform X1

  6. XM_047448420.1 → XP_047304376.1  transmembrane protein 45A isoform X1

  7. XM_047448422.1 → XP_047304378.1  transmembrane protein 45A isoform X2

  8. XM_047448421.1 → XP_047304377.1  transmembrane protein 45A isoform X1

  9. XM_047448423.1 → XP_047304379.1  transmembrane protein 45A isoform X2

  10. XM_047448424.1 → XP_047304380.1  transmembrane protein 45A isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    103198293..103283136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347041.1 → XP_054203016.1  transmembrane protein 45A isoform X3

    UniProtKB/TrEMBL
    J3KQ06

  2. XM_054347043.1 → XP_054203018.1  transmembrane protein 45A isoform X3

    UniProtKB/TrEMBL
    J3KQ06

  3. XM_054347042.1 → XP_054203017.1  transmembrane protein 45A isoform X3

    UniProtKB/TrEMBL
    J3KQ06

  4. XM_054347035.1 → XP_054203010.1  transmembrane protein 45A isoform X1

  5. XM_054347038.1 → XP_054203013.1  transmembrane protein 45A isoform X1

  6. XM_054347036.1 → XP_054203011.1  transmembrane protein 45A isoform X1

  7. XM_054347037.1 → XP_054203012.1  transmembrane protein 45A isoform X1

  8. XM_054347039.1 → XP_054203014.1  transmembrane protein 45A isoform X2

  9. XM_054347040.1 → XP_054203015.1  transmembrane protein 45A isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWC5.1 GenPept UniProtKB/Swiss-Prot:Q9NWC5

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