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NBDY negative regulator of P-body association [ Homo sapiens (human) ]

Gene ID: 550643, updated on 5-Mar-2024

Summary

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Official Symbol
NBDYprovided by HGNC
Official Full Name
negative regulator of P-body associationprovided by HGNC
Primary source
HGNC:HGNC:50713
See related
Ensembl:ENSG00000204272 MIM:300992; AllianceGenome:HGNC:50713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NoBody; LINC01420
Summary
Involved in negative regulation of cytoplasmic mRNA processing body assembly and nuclear-transcribed mRNA catabolic process. Located in P-body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 34.2), adrenal (RPKM 31.8) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
Xp11.21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (56729243..56819179)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (56022640..56117983)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (56755676..56845612)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:56589763-56590390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29688 Neighboring gene ubiquilin 2 Neighboring gene uncharacterized LOC124905194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:56790193-56790694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29695 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:56796358-56796874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:56796875-56797391 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:56798078-56798669 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:56798670-56799260 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:56799261-56799852 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:56804396-56805293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:56805294-56806192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29700 Neighboring gene Sharpr-MPRA regulatory region 15663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29701 Neighboring gene spindlin family member 3 Neighboring gene SPIN2 family pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The NBDY Microprotein Regulates Cellular RNA Decapping. Na Z, et al. Biochemistry, 2020 Oct 27. PMID 33059440, Free PMC Article
  2. LINC01420 RNA structure and influence on cell physiology. Konina DO, et al. BMC Genomics, 2019 May 8. PMID 32039714, Free PMC Article
  3. Long Non-coding RNA LINC01420 Contributes to Pancreatic Cancer Progression Through Targeting KRAS Proto-oncogene. Zhai H, et al. Dig Dis Sci, 2020 Apr. PMID 31562613
  4. A human microprotein that interacts with the mRNA decapping complex. D'Lima NG, et al. Nat Chem Biol, 2017 Feb. PMID 27918561, Free PMC Article
  5. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. Evans DM, et al. Hum Mol Genet, 2013 Oct 1. PMID 23720494, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long Non-coding RNA LINC01420 Contributes to Pancreatic Cancer Progression Through Targeting KRAS Proto-oncogene.
    Title: Long Non-coding RNA LINC01420 Contributes to Pancreatic Cancer Progression Through Targeting KRAS Proto-oncogene.
  2. LINC01420 RNA structure and influence on cell physiology
    Title: LINC01420 RNA structure and influence on cell physiology.
  3. results implicate NoBody as a novel component of the mRNA decapping complex and demonstrate potential functionality of a newly discovered microprotein
    Title: A human microprotein that interacts with the mRNA decapping complex.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytoplasmic mRNA processing body assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
negative regulator of P-body association
Names
P-body dissociating protein
long intergenic non-protein coding RNA 1420
non-annotated P-body dissociating polypeptide
protein NoBody

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348129.2 → NP_001335058.1  negative regulator of P-body association

    Status: VALIDATED

    Source sequence(s)
    AA131515, AL158200, AL354865, BC048131, BX537532, CA444043
    Consensus CDS
    CCDS87751.1
    UniProtKB/Swiss-Prot
    A0A0U1RRE5
    UniProtKB/TrEMBL
    A0A4P8PLQ7
    Related
    ENSP00000489583.1, ENST00000374922.9
    Conserved Domains (1) summary
    cd20243
    Location:1 → 68
    NoBody; Negative regulator of P-body association

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    56729243..56819179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    56022640..56117983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0U1RRE5.1 GenPept UniProtKB/Swiss-Prot:A0A0U1RRE5

Gene LinkOut

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Molecular Biology Databases
Research Materials