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VPS37C VPS37C subunit of ESCRT-I [ Homo sapiens (human) ]

Gene ID: 55048, updated on 7-Apr-2024

Summary

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Official Symbol
VPS37Cprovided by HGNC
Official Full Name
VPS37C subunit of ESCRT-Iprovided by HGNC
Primary source
HGNC:HGNC:26097
See related
Ensembl:ENSG00000167987 MIM:610038; AllianceGenome:HGNC:26097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 9.4), placenta (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q12.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61130257..61161426, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61081750..61112918, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60897729..60928898, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369325 Neighboring gene uncharacterized LOC124902677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60859431-60860393 Neighboring gene CD5 molecule Neighboring gene Sharpr-MPRA regulatory region 3147/8872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60902229-60902744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60902745-60903260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60904582-60905082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60905083-60905583 Neighboring gene H3K27ac hESC enhancers GRCh37_chr11:60928361-60928954 and GRCh37_chr11:60928955-60929547 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:60933107-60933784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3386 Neighboring gene uncharacterized LOC124902678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60960971-60961472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60961473-60961972 Neighboring gene pepsinogen A3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. Wunderley L, et al. J Cell Sci, 2014 Feb 1. PMID 24284069, Free PMC Article
  2. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. Eastman SW, et al. J Biol Chem, 2005 Jan 7. PMID 15509564
  3. A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission. Flower TG, et al. Nat Struct Mol Biol, 2020 Jun. PMID 32424346, Free PMC Article
  4. VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I. Okumura M, et al. Biosci Biotechnol Biochem, 2013. PMID 23924735
  5. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Agromayor M, et al. Structure, 2012 Mar 7. PMID 22405001, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VPS37C facilitates erythroid differentiation by promoting EKLF stability.
    Title: VPS37C facilitates erythroid differentiation by promoting EKLF stability.
  2. VPS37B and appeared to interact with ALG-2 in a stronger manner than TSG101 does
    Title: VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
  5. VPS37C as a functional component of mammalian endosomal sorting complex required for transport-I
    Title: Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20847

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in macroautophagy TAS
Traceable Author Statement
more info
 PubMed 
involved_in membrane fission NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in multivesicular body assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in multivesicular body assembly TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in viral budding via host ESCRT complex TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ESCRT I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of ESCRT I complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ESCRT I complex TAS
Traceable Author Statement
more info
 PubMed 
located_in endosome membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endosome membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 37C
Names
ESCRT-I complex subunit VPS37C
VPS37C, ESCRT-I subunit
hVps37C
vacuolar protein sorting 37 homolog C
vacuolar protein sorting 37C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017966.5 → NP_060436.4  vacuolar protein sorting-associated protein 37C

    See identical proteins and their annotated locations for NP_060436.4

    Status: VALIDATED

    Source sequence(s)
    AL834261, BM450171
    Consensus CDS
    CCDS31573.1
    UniProtKB/Swiss-Prot
    A5D8V6, Q8N3K4
    UniProtKB/TrEMBL
    B4DYD9
    Related
    ENSP00000301765.5, ENST00000301765.10
    Conserved Domains (1) summary
    pfam07200
    Location:5 → 146
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    61130257..61161426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427178.1 → XP_047283134.1  vacuolar protein sorting-associated protein 37C isoform X2

  2. XM_005274077.4 → XP_005274134.1  vacuolar protein sorting-associated protein 37C isoform X1

    See identical proteins and their annotated locations for XP_005274134.1

    UniProtKB/Swiss-Prot
    A5D8V6, Q8N3K4
    UniProtKB/TrEMBL
    B4DYD9
    Conserved Domains (1) summary
    pfam07200
    Location:5 → 146
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  3. XM_047427179.1 → XP_047283135.1  vacuolar protein sorting-associated protein 37C isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    61081750..61112918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369224.1 → XP_054225199.1  vacuolar protein sorting-associated protein 37C isoform X2

  2. XM_054369223.1 → XP_054225198.1  vacuolar protein sorting-associated protein 37C isoform X1

  3. XM_054369225.1 → XP_054225200.1  vacuolar protein sorting-associated protein 37C isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5D8V6.2 GenPept UniProtKB/Swiss-Prot:A5D8V6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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