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TRMT61B tRNA methyltransferase 61B [ Homo sapiens (human) ]

Gene ID: 55006, updated on 11-Apr-2024

Summary

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Official Symbol
TRMT61Bprovided by HGNC
Official Full Name
tRNA methyltransferase 61Bprovided by HGNC
Primary source
HGNC:HGNC:26070
See related
Ensembl:ENSG00000171103 MIM:619404; AllianceGenome:HGNC:26070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables mRNA (adenine-N1-)-methyltransferase activity; rRNA (adenine) methyltransferase activity; and tRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation; mitochondrial tRNA methylation; and protein homooligomerization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.4), small intestine (RPKM 6.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
2p23.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (28849821..28870309, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (28893430..28914555, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (29072687..29093175, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:28945848-28946348 Neighboring gene MPRA-validated peak3641 silencer Neighboring gene PPP1CB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:28974622-28975266 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:28978040-28978253 Neighboring gene protein phosphatase 1 catalytic subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11314 Neighboring gene speedy/RINGO cell cycle regulator family member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29091169-29091684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:29091685-29092199 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29092829-29093353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15527 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:29105260-29105423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11315 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29117677-29118300 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:29118301-29118922 Neighboring gene WD repeat domain 43 Neighboring gene small nucleolar RNA, C/D box 92 Neighboring gene small nucleolar RNA, C/D box 53

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates. Bar-Yaacov D, et al. PLoS Biol, 2016 Sep. PMID 27631568, Free PMC Article
  2. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. Chujo T, et al. RNA, 2012 Dec. PMID 23097428, Free PMC Article
  3. Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Li X, et al. Mol Cell, 2017 Dec 7. PMID 29107537, Free PMC Article
  4. APEX Fingerprinting Reveals the Subcellular Localization of Proteins of Interest. Lee SY, et al. Cell Rep, 2016 May 24. PMID 27184847
  5. Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders. Li J, et al. Cell Syst, 2015 Nov 25. PMID 26949739, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRMT61B rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers.
    Title: TRMT61B rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers.
  2. 16S rRNA RNA-DNA differences result from a 1-methyladenosine (m1A) modification introduced by TRMT61B.
    Title: Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates.
  3. Unlike the cytoplasmic tRNA m(1)A58 methyltransferase that consists of an alpha2beta2 heterotetramer formed by Trmt61A and Trmt6, Trmt61B formed a homo-oligomer (presumably a homotetramer) that resembled the bacterial homotetrameric m(1)A58 methyltransferase.
    Title: Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20628, DKFZp564I2178

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA (adenine-N1-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA (adenine) methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA (adenine(58)-N1)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial tRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
Names
mRNA methyladenosine-N(1)-methyltransferase
potential tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61B
potential tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61B
tRNA methyltransferase 61 homolog B
NP_060380.3
XP_005264450.1
XP_006712100.1
XP_016859890.1
XP_016859892.1
XP_047300796.1
XP_047300797.1
XP_047300798.1
XP_047300799.1
XP_047300800.1
XP_054198662.1
XP_054198663.1
XP_054198664.1
XP_054198665.1
XP_054198666.1
XP_054198667.1
XP_054198668.1
XP_054198669.1
XP_054198670.1
XP_054198671.1
XP_054198672.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017910.4 → NP_060380.3  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_060380.3

    Status: VALIDATED

    Source sequence(s)
    AC097720, AL136689, BC000952
    Consensus CDS
    CCDS1768.1
    UniProtKB/Swiss-Prot
    Q9BVS5, Q9H0Q9, Q9NWS7
    Related
    ENSP00000302801.5, ENST00000306108.10
    Conserved Domains (1) summary
    cl25960
    Location:150 → 474
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    28849821..28870309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444843.1 → XP_047300799.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X7

  2. XM_017004401.3 → XP_016859890.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X3

  3. XM_006712037.4 → XP_006712100.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X2

    Conserved Domains (2) summary
    COG2519
    Location:150 → 376
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam10577
    Location:43 → 141
    UPF0560; uncharacterized protein family UPF0560

  4. XM_047444841.1 → XP_047300797.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X5

    UniProtKB/TrEMBL
    F8WDR2
    Related
    ENSP00000389617.1, ENST00000439947.1

  5. XM_005264393.4 → XP_005264450.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X1

    Conserved Domains (3) summary
    COG2519
    Location:150 → 465
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]
    pfam10577
    Location:43 → 141
    UPF0560; uncharacterized protein family UPF0560
    cl17173
    Location:227 → 457
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. XM_017004403.2 → XP_016859892.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X9

  7. XM_047444840.1 → XP_047300796.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X4

  8. XM_047444842.1 → XP_047300798.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X6

  9. XM_047444844.1 → XP_047300800.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X8

RNA

  1. XR_939691.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    28893430..28914555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342693.1 → XP_054198668.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X7

  2. XM_054342689.1 → XP_054198664.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X3

  3. XM_054342688.1 → XP_054198663.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X2

  4. XM_054342691.1 → XP_054198666.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X5

    UniProtKB/TrEMBL
    F8WDR2

  5. XM_054342687.1 → XP_054198662.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X1

  6. XM_054342697.1 → XP_054198672.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X9

  7. XM_054342690.1 → XP_054198665.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X4

  8. XM_054342692.1 → XP_054198667.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X6

  9. XM_054342694.1 → XP_054198669.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X8

  10. XM_054342696.1 → XP_054198671.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X10

  11. XM_054342695.1 → XP_054198670.1  tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial isoform X10

RNA

  1. XR_008486422.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BVS5.2 GenPept UniProtKB/Swiss-Prot:Q9BVS5

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