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DUSP23 dual specificity phosphatase 23 [ Homo sapiens (human) ]

Gene ID: 54935, updated on 5-Mar-2024

Summary

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Official Symbol
DUSP23provided by HGNC
Official Full Name
dual specificity phosphatase 23provided by HGNC
Primary source
HGNC:HGNC:21480
See related
Ensembl:ENSG00000158716 MIM:618361; AllianceGenome:HGNC:21480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VHZ; LDP3; MOSP; LDP-3; DUSP25
Summary
Enables protein tyrosine/serine/threonine phosphatase activity. Involved in dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 18.6), liver (RPKM 13.3) and 25 other tissues See more
Orthologs
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Genomic context

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See DUSP23 in Genome Data Viewer
Location:
1q23.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159780962..159782543)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158917974..158919555)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159750752..159752333)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27 pseudogene 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:159737419-159738372 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:159738373-159739326 Neighboring gene uncharacterized LOC101928264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:159751068-159751644 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9322 Neighboring gene Sharpr-MPRA regulatory region 9392 Neighboring gene uncharacterized LOC105371464 Neighboring gene Fc receptor like 6 Neighboring gene SLAM family member 8 Neighboring gene small nucleolar RNA host gene 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DUSP23 is over-expressed and linked to the expression of DNMTs in CD4(+) T cells from systemic lupus erythematosus patients. Balada E, et al. Clin Exp Immunol, 2017 Feb. PMID 27737517, Free PMC Article
  2. Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data. Nyberg F, et al. Pharmacogenomics, 2011 Jul. PMID 21787189
  3. VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers. Tang JP, et al. Mol Cancer, 2010 May 28. PMID 20509867, Free PMC Article
  4. The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ. Alonso A, et al. J Biol Chem, 2004 Aug 20. PMID 15201283
  5. Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain. Wu Q, et al. Int J Biochem Cell Biol, 2004 Aug. PMID 15147733

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that DUSP23 mRNA levels in CD4+ T cells are higher in the systemic lupus erythematosus patients
    Title: DUSP23 is over-expressed and linked to the expression of DNMTs in CD4(+) T cells from systemic lupus erythematosus patients.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. The upregulation of VHZ levels in primary human cancers supports the clinical relevance of this protein in cancers
    Title: VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancers.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
  5. DUSP23 showed distinctive phosphatase activity toward p-nitrophenyl phosphate, as well as oligopeptides containing phospho-tyrosine and phospho-threonine residues. Furthermore, DUSP23 could dephosphorylate p44ERK1 but not p38 and p54SAPKbeta in vitro
    Title: Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain.
  6. the smallest active protein-tyrosine phosphatase yet (only 16 kDa) belongs to the group of small Vaccinia virus VH1-related dual specific phosphatases; gene is located on human chromosome 1q23.1 and consists of only two coding exons
    Title: The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
EBI GWAS Catalog
Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ20442

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 23
Names
VH1-like member Z
VH1-like phosphatase Z
low-molecular-mass dual-specificity phosphatase 3
testicular tissue protein Li 59
NP_001306587.1
NP_001306588.1
NP_060293.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319658.2 → NP_001306587.1  dual specificity protein phosphatase 23

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB164404, AL590560, BG823348, DA428735
    Consensus CDS
    CCDS1187.1
    UniProtKB/Swiss-Prot
    Q9BVJ7, Q9NX48
    UniProtKB/TrEMBL
    A0A140VJI5
    Related
    ENSP00000357087.1, ENST00000368107.2
    Conserved Domains (1) summary
    cd14504
    Location:8 → 148
    DUSP23; dual specificity phosphatase 23

  2. NM_001319659.2 → NP_001306588.1  dual specificity protein phosphatase 23

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BQ679163
    Consensus CDS
    CCDS1187.1
    UniProtKB/Swiss-Prot
    Q9BVJ7, Q9NX48
    UniProtKB/TrEMBL
    A0A140VJI5
    Related
    ENSP00000357089.1, ENST00000368109.5
    Conserved Domains (1) summary
    cd14504
    Location:8 → 148
    DUSP23; dual specificity phosphatase 23

  3. NM_017823.5 → NP_060293.2  dual specificity protein phosphatase 23

    See identical proteins and their annotated locations for NP_060293.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC001140, BQ679163
    Consensus CDS
    CCDS1187.1
    UniProtKB/Swiss-Prot
    Q9BVJ7, Q9NX48
    UniProtKB/TrEMBL
    A0A140VJI5
    Related
    ENSP00000357088.3, ENST00000368108.7
    Conserved Domains (1) summary
    cd14504
    Location:8 → 148
    DUSP23; dual specificity phosphatase 23

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159780962..159782543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    158917974..158919555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BVJ7.1 GenPept UniProtKB/Swiss-Prot:Q9BVJ7

Gene LinkOut

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