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ST7L suppression of tumorigenicity 7 like [ Homo sapiens (human) ]

Gene ID: 54879, updated on 3-Apr-2024

Summary

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Official Symbol
ST7Lprovided by HGNC
Official Full Name
suppression of tumorigenicity 7 likeprovided by HGNC
Primary source
HGNC:HGNC:18441
See related
Ensembl:ENSG00000007341 MIM:617640; AllianceGenome:HGNC:18441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST7R; STLR; FAM4B
Summary
This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
Expression
Broad expression in testis (RPKM 6.6), skin (RPKM 3.2) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
1p13.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112517803..112619684, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112530373..112632344, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113066136..113161763, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1195 Neighboring gene CTTNBP2 N-terminal like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:112947097-112947622 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:112950375-112950562 Neighboring gene Sharpr-MPRA regulatory region 6417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1513 Neighboring gene MPRA-validated peak369 silencer Neighboring gene microRNA 4256 Neighboring gene Wnt family member 2B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113050855-113051398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1198 Neighboring gene Sharpr-MPRA regulatory region 8072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113052323-113052822 Neighboring gene MPRA-validated peak370 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1514 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:113161935-113163134 Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31. Katoh M. Int J Oncol, 2002 Jun. PMID 12012006
  2. MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/β-Catenin Signal via ST7L. Zhan T, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 32924881, Free PMC Article
  3. Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3β/β-catenin signalling. Wang H, et al. Clin Exp Pharmacol Physiol, 2020 Jan. PMID 31429477
  4. miR-331-3p functions as an oncogene by targeting ST7L in pancreatic cancer. Chen X, et al. Carcinogenesis, 2018 Jul 30. PMID 29850766
  5. miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer. Li S, et al. Int J Mol Med, 2017 Oct. PMID 28902356, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/beta-Catenin Signal via ST7L.
    Title: MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/β-Catenin Signal via ST7L.
  2. Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3beta/beta-catenin signalling.
    Title: Suppression of the proliferation and invasion of breast cancer cells by ST7L occurs through inhibition of activation of Wnt/GSK-3β/β-catenin signalling.
  3. Study found that miR-331-3p was significantly upregulated in tumor specimens of pancreatic cancer (PC) patients and cell lines. Downregulation of miR-331-3p inhibited PC cell proliferation and epithelial-mesenchymal transition-mediated metastasis in vitro. ST7L was identified as a novel target gene of miR-331-3p. Results demonstrate that miR-331-3p is a tumor-promoting microRNA and a promising biomarker for PC.
    Title: miR-331-3p functions as an oncogene by targeting ST7L in pancreatic cancer.
  4. overexpression of MIR31HG enhanced the expression of suppression of tumorigenicity 7 like (ST7L), which was identified as a downstream target gene of miR-575. Thus, MIR31HG positively regulated ST7L expression through sponging miR-575, and acted as tumor suppressor in hepatocellular carcinoma (HCC).
    Title: Long noncoding RNA MIR31HG inhibits hepatocellular carcinoma proliferation and metastasis by sponging microRNA-575 to modulate ST7L expression.
  5. miR-378 functions as an onco-miRNA by directly downregulating ST7L mRNA and protein level.
    Title: miR-378 functions as an onco-miRNA by targeting the ST7L/Wnt/β-catenin pathway in cervical cancer.
  6. This study revealed important roles of miR-23b and ST7L in progression of Hepatocellular carcinoma.
    Title: MicroRNA-23b functions as an oncogene and activates AKT/GSK3β/β-catenin signaling by targeting ST7L in hepatocellular carcinoma.
  7. miR-24 is a direct regulator of ST7L.
    Title: MiR-24 regulates the proliferation and invasion of glioma by ST7L via β-catenin/Tcf-4 signaling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11657, FLJ20284

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
suppressor of tumorigenicity 7 protein-like
Names
ST7-related protein
tumor suppressor ST7 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308264.2 → NP_001295193.1  suppressor of tumorigenicity 7 protein-like isoform 7

    See identical proteins and their annotated locations for NP_001295193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate 5' terminal exon and lacks an alternate exon in its 5' UTR. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (7) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB081317, AK097837, AL109932, AL929470, BC047392, BX537988, BX538338
    Consensus CDS
    CCDS76189.1
    UniProtKB/TrEMBL
    B3KTN0
    Related
    ENSP00000358683.1, ENST00000369669.5
    Conserved Domains (1) summary
    cd11557
    Location:1 → 355
    ST7; Suppression of tumorigenicity 7

  2. NM_017744.5 → NP_060214.2  suppressor of tumorigenicity 7 protein-like isoform 1

    See identical proteins and their annotated locations for NP_060214.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB081317, AL109932, BX538338
    Consensus CDS
    CCDS848.1
    UniProtKB/Swiss-Prot
    A8K4S7, Q49AH6, Q5TEI4, Q5U5K6, Q6N067, Q7Z2Z0, Q7Z3C2, Q8N7P8, Q8TDW1, Q8TDW2, Q8TDW3, Q8TDW4, Q9NXF3
    UniProtKB/TrEMBL
    B7Z3J2
    Related
    ENSP00000350734.4, ENST00000358039.9
    Conserved Domains (1) summary
    pfam04184
    Location:43 → 552
    ST7; ST7 protein

  3. NM_138727.4 → NP_620055.1  suppressor of tumorigenicity 7 protein-like isoform 2

    See identical proteins and their annotated locations for NP_620055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in an isoform (2) that is missing an internal region, as compared to isoform 1.
    Source sequence(s)
    AB081318, AL109932, BX538338
    Consensus CDS
    CCDS849.1
    UniProtKB/TrEMBL
    B7Z3J2
    Related
    ENSP00000417140.1, ENST00000490067.5
    Conserved Domains (1) summary
    cd11557
    Location:69 → 521
    ST7; Suppression of tumorigenicity 7

  4. NM_138728.3 → NP_620056.1  suppressor of tumorigenicity 7 protein-like isoform 3

    See identical proteins and their annotated locations for NP_620056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment, compared to variant 1, resulting in an isoform (3) that is missing an internal region, as compared to isoform 1.
    Source sequence(s)
    AB081319, AL109932, BX538338
    Consensus CDS
    CCDS850.1
    UniProtKB/TrEMBL
    B7Z3J2
    Related
    ENSP00000353972.4, ENST00000360743.8
    Conserved Domains (1) summary
    cd11557
    Location:72 → 507
    ST7; Suppression of tumorigenicity 7

  5. NM_138729.4 → NP_620057.1  suppressor of tumorigenicity 7 protein-like isoform 4

    See identical proteins and their annotated locations for NP_620057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, when compared to variant 1, resulting in an isoform (4) that has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AB081320, AL109932, BC027898
    Consensus CDS
    CCDS852.1
    UniProtKB/TrEMBL
    B7Z7D4
    Related
    ENSP00000345312.7, ENST00000343210.11
    Conserved Domains (1) summary
    cd11557
    Location:72 → 538
    ST7; Suppression of tumorigenicity 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    112517803..112619684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541628.3 → XP_011539930.1  suppressor of tumorigenicity 7 protein-like isoform X2

    UniProtKB/TrEMBL
    B7Z7D4
    Conserved Domains (1) summary
    cd11557
    Location:72 → 538
    ST7; Suppression of tumorigenicity 7

  2. XM_011541631.4 → XP_011539933.1  suppressor of tumorigenicity 7 protein-like isoform X6

    See identical proteins and their annotated locations for XP_011539933.1

    UniProtKB/TrEMBL
    B7Z7D4
    Conserved Domains (1) summary
    cd11557
    Location:12 → 416
    ST7; Suppression of tumorigenicity 7

  3. XM_047423352.1 → XP_047279308.1  suppressor of tumorigenicity 7 protein-like isoform X6

  4. XM_047423341.1 → XP_047279297.1  suppressor of tumorigenicity 7 protein-like isoform X1

    UniProtKB/Swiss-Prot
    A8K4S7, Q49AH6, Q5TEI4, Q5U5K6, Q6N067, Q7Z2Z0, Q7Z3C2, Q8N7P8, Q8TDW1, Q8TDW2, Q8TDW3, Q8TDW4, Q9NXF3
    Related
    ENSP00000436544.1, ENST00000490715.5

  5. XM_047423368.1 → XP_047279324.1  suppressor of tumorigenicity 7 protein-like isoform X9

  6. XM_047423372.1 → XP_047279328.1  suppressor of tumorigenicity 7 protein-like isoform X6

  7. XM_047423358.1 → XP_047279314.1  suppressor of tumorigenicity 7 protein-like isoform X6

  8. XM_047423351.1 → XP_047279307.1  suppressor of tumorigenicity 7 protein-like isoform X5

  9. XM_047423350.1 → XP_047279306.1  suppressor of tumorigenicity 7 protein-like isoform X4

  10. XM_011541629.3 → XP_011539931.1  suppressor of tumorigenicity 7 protein-like isoform X3

    UniProtKB/TrEMBL
    B7Z7D4
    Conserved Domains (1) summary
    cd11557
    Location:16 → 482
    ST7; Suppression of tumorigenicity 7

  11. XM_047423374.1 → XP_047279330.1  suppressor of tumorigenicity 7 protein-like isoform X12

  12. XM_047423373.1 → XP_047279329.1  suppressor of tumorigenicity 7 protein-like isoform X11

  13. XM_047423369.1 → XP_047279325.1  suppressor of tumorigenicity 7 protein-like isoform X10

  14. XM_017001535.2 → XP_016857024.1  suppressor of tumorigenicity 7 protein-like isoform X8

    UniProtKB/TrEMBL
    B7Z8V6

  15. XM_047423363.1 → XP_047279319.1  suppressor of tumorigenicity 7 protein-like isoform X7

RNA

  1. XR_007061293.1 RNA Sequence

  2. XR_007061292.1 RNA Sequence

  3. XR_007061291.1 RNA Sequence

  4. XR_946675.3 RNA Sequence

  5. XR_007061297.1 RNA Sequence

  6. XR_007061295.1 RNA Sequence

  7. XR_007061296.1 RNA Sequence

  8. XR_007061294.1 RNA Sequence

  9. XR_007061298.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    112530373..112632344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337233.1 → XP_054193208.1  suppressor of tumorigenicity 7 protein-like isoform X2

  2. XM_054337238.1 → XP_054193213.1  suppressor of tumorigenicity 7 protein-like isoform X6

  3. XM_054337242.1 → XP_054193217.1  suppressor of tumorigenicity 7 protein-like isoform X9

  4. XM_054337244.1 → XP_054193219.1  suppressor of tumorigenicity 7 protein-like isoform X6

  5. XM_054337239.1 → XP_054193214.1  suppressor of tumorigenicity 7 protein-like isoform X6

  6. XM_054337237.1 → XP_054193212.1  suppressor of tumorigenicity 7 protein-like isoform X5

  7. XM_054337236.1 → XP_054193211.1  suppressor of tumorigenicity 7 protein-like isoform X4

  8. XM_054337235.1 → XP_054193210.1  suppressor of tumorigenicity 7 protein-like isoform X3

  9. XM_054337246.1 → XP_054193221.1  suppressor of tumorigenicity 7 protein-like isoform X12

  10. XM_054337245.1 → XP_054193220.1  suppressor of tumorigenicity 7 protein-like isoform X11

  11. XM_054337234.1 → XP_054193209.1  suppressor of tumorigenicity 7 protein-like isoform X14

  12. XM_054337232.1 → XP_054193207.1  suppressor of tumorigenicity 7 protein-like isoform X13

  13. XM_054337243.1 → XP_054193218.1  suppressor of tumorigenicity 7 protein-like isoform X10

  14. XM_054337241.1 → XP_054193216.1  suppressor of tumorigenicity 7 protein-like isoform X8

  15. XM_054337240.1 → XP_054193215.1  suppressor of tumorigenicity 7 protein-like isoform X7

RNA

  1. XR_008486070.1 RNA Sequence

  2. XR_008486074.1 RNA Sequence

  3. XR_008486072.1 RNA Sequence

  4. XR_008486073.1 RNA Sequence

  5. XR_008486071.1 RNA Sequence

  6. XR_008486075.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198327.1: Suppressed sequence

    Description
    NM_198327.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and the protein also lacks homolog support.

  2. NM_198328.1: Suppressed sequence

    Description
    NM_198328.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and the protein also lacks homolog support.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TDW4.1 GenPept UniProtKB/Swiss-Prot:Q8TDW4

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