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SNRK SNF related kinase [ Homo sapiens (human) ]

Gene ID: 54861, updated on 3-Apr-2024

Summary

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Official Symbol
SNRKprovided by HGNC
Official Full Name
SNF related kinaseprovided by HGNC
Primary source
HGNC:HGNC:30598
See related
Ensembl:ENSG00000163788 MIM:612760; AllianceGenome:HGNC:30598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSNFRK
Summary
SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 23.2), thyroid (RPKM 20.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (43286540..43351143)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (43301825..43366451)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (43328032..43392635)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377051 Neighboring gene Sharpr-MPRA regulatory regions 3209 and 6245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19752 Neighboring gene uncharacterized LOC105377052 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:43327772-43328272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14255 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:43330978-43331205 Neighboring gene MPRA-validated peak4622 silencer Neighboring gene RNA, 7SL, cytoplasmic 517, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:43410923-43411423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:43413051-43413632 Neighboring gene SNRK antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1625 Neighboring gene anoctamin 10 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:43496575-43497774 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:43520239-43520811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:43532352-43532852 Neighboring gene ribosomal protein L18a pseudogene 9 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:43577638-43578572 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:43607028-43607750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:43663772-43664424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:43664425-43665077 Neighboring gene tubulin alpha pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal structure of the kinase and UBA domains of SNRK reveals a distinct UBA binding mode in the AMPK family. Wang YL, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29061304
  2. Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features. Hopp EE, et al. Cancer Invest, 2017 Aug 9. PMID 28722495, Free PMC Article
  3. Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin. Rines AK, et al. FASEB J, 2012 Nov. PMID 22874833, Free PMC Article
  4. SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons. Yoshida K, et al. Brain Res, 2000 Aug 11. PMID 10930554
  5. Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases. Becker W, et al. Eur J Biochem, 1996 Feb 1. PMID 8654423

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p/HDAC2/SNRK.
    Title: Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p/HDAC2/SNRK.
  2. Study shows that TRIB3 binds to SNRK, and downregulates UCP3 through PPARalpha. SNRK is increased in cardiomyopathy patients, and SNRK reduces infarct size after ischaemia/reperfusion. SNRK also decreases cardiac cell death in a UCP3-dependent manner.
    Title: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.
  3. Report the crystal structure of an N-terminal SNRK fragment containing kinase and adjacent ubiquitin-associated (UBA) domains. This structure shows that the UBA domain binds between the N- and C-lobes of the kinase domain. The mode of UBA binding in SNRK largely resembles that in AMPK and brain specific kinase (BRSK), however, unique interactions play vital roles in stabilizing the KD-UBA interface of SNRK.
    Title: Crystal structure of the kinase and UBA domains of SNRK reveals a distinct UBA binding mode in the AMPK family.
  4. SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
    Title: Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function.
  5. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.
    Title: Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features.
  6. SNRK inhibits colon cancer cell proliferation through calcyclin-binding protein up-regulation and beta-catenin degradation, which results in reduced proliferation signaling.
    Title: Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin.
  7. These findings reveal a novel function for SNRK in the regulation of colon cancer cell proliferation and beta-catenin signaling.
    Title: Snf1-related kinase inhibits colon cancer cell proliferation through calcyclin-binding protein-dependent reduction of β-catenin.
  8. SNRK could mediate some of the physiological effects of LKB1
    Title: Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20224, KIAA0096, DKFZp779A1866

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in myeloid cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
SNF-related serine/threonine-protein kinase
Names
SNF-1 related kinase
SNF1-related kinase
NP_001094064.1
NP_001317679.1
NP_060189.3
XP_005265302.1
XP_047304352.1
XP_047304353.1
XP_047304354.1
XP_054202975.1
XP_054202976.1
XP_054202977.1
XP_054202978.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100594.2 → NP_001094064.1  SNF-related serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_001094064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK025449, BC071567, D43636, DA769463, DB080037
    Consensus CDS
    CCDS43075.1
    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7
    UniProtKB/TrEMBL
    A8K5P5
    Related
    ENSP00000411375.2, ENST00000429705.6
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  2. NM_001330750.2 → NP_001317679.1  SNF-related serine/threonine-protein kinase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK025449, AK291360, AK295187, D43636
    Consensus CDS
    CCDS82759.1
    UniProtKB/TrEMBL
    B4DHM9, E7EUC4
    Related
    ENSP00000409516.1, ENST00000437827.1
    Conserved Domains (2) summary
    cd14339
    Location:82 → 129
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cl21453
    Location:1 → 63
    PKc_like; Protein Kinases, catalytic domain

  3. NM_017719.5 → NP_060189.3  SNF-related serine/threonine-protein kinase isoform 1

    See identical proteins and their annotated locations for NP_060189.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK025449, BP281284, D43636, DB080037
    Consensus CDS
    CCDS43075.1
    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7
    UniProtKB/TrEMBL
    A8K5P5
    Related
    ENSP00000296088.7, ENST00000296088.12
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    43286540..43351143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448396.1 → XP_047304352.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7

  2. XM_005265245.4 → XP_005265302.1  SNF-related serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_005265302.1

    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7
    UniProtKB/TrEMBL
    A8K5P5
    Related
    ENSP00000401246.1, ENST00000454177.5
    Conserved Domains (2) summary
    cd14339
    Location:288 → 335
    UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
    cd14074
    Location:12 → 269
    STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

  3. XM_047448397.1 → XP_047304353.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7

  4. XM_047448398.1 → XP_047304354.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    43301825..43366451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347001.1 → XP_054202976.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7

  2. XM_054347002.1 → XP_054202977.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7

  3. XM_054347000.1 → XP_054202975.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7

  4. XM_054347003.1 → XP_054202978.1  SNF-related serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    B2RAV6, Q14706, Q68D15, Q6IQ46, Q9NRH2, Q9NXI7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRH2.2 GenPept UniProtKB/Swiss-Prot:Q9NRH2

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