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GON4L gon-4 like [ Homo sapiens (human) ]

Gene ID: 54856, updated on 3-Apr-2024

Summary

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Official Symbol
GON4Lprovided by HGNC
Official Full Name
gon-4 likeprovided by HGNC
Primary source
HGNC:HGNC:25973
See related
Ensembl:ENSG00000116580 MIM:610393; AllianceGenome:HGNC:25973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GON4; YARP; GON-4
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within B cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 11.0), spleen (RPKM 8.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1q22
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155745112..155859431, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154888528..154998299, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155719450..155829222, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene YY1 associated protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155657971-155658605 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1818 Neighboring gene uncharacterized LOC124904431 Neighboring gene death associated protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1819 Neighboring gene misato family member 2, pseudogene Neighboring gene small Cajal body-specific RNA 26B Neighboring gene Sharpr-MPRA regulatory region 7686 Neighboring gene proteasome 26S subunit, non-ATPase 7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155827371-155827958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1822 Neighboring gene synaptotagmin 11 Neighboring gene uncharacterized LOC124904686

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis. Agarwal N, et al. Cancer Res, 2016 Sep 1. PMID 27312530, Free PMC Article
  2. Molecular cloning of a structural homolog of YY1AP, a coactivator of the multifunctional transcription factor YY1. Ohtomo T, et al. Amino Acids, 2007 Nov. PMID 17297563
  3. Cloning and expression analysis of YY1AP-related protein in the rat brain. Ohtomo T, et al. Amino Acids, 2008 Jan. PMID 17285227
  4. Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations. Bucholc K, et al. Int J Mol Sci, 2020 Jul 24. PMID 32722282, Free PMC Article
  5. A conserved interaction that is essential for the biogenesis of histone locus bodies. Yang XC, et al. J Biol Chem, 2014 Dec 5. PMID 25339177, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations.
    Title: Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations.
  2. our results define GON4L as a novel driver of cancer growth
    Title: GON4L Drives Cancer Growth through a YY1-Androgen Receptor-CD24 Axis.
  3. The conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins to histone locus bodies.
    Title: A conserved interaction that is essential for the biogenesis of histone locus bodies.
  4. Sin3a, HDAC1, and YY1 are co-factors for Gon4l and that Gon4l may function as a platform for the assembly of complexes that regulate gene expression.
    Title: The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. study describes the cloning of a novel homolog of YY1AP, referred to as YARP; it is proposed that YARP is multifunctional and plays not only a role analogous to YY1AP, but also its own specific roles in DNA-utilizing processes such as transcription
    Title: Molecular cloning of a structural homolog of YY1AP, a coactivator of the multifunctional transcription factor YY1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12923, FLJ20203, FLJ23040, KIAA1606, MGC138817, MGC138818, DKFZp761I241, RP11-101O6.1, RP11-243J18.4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GON-4-like protein
Names
2610100B20Rik
YY1AP related protein
YY1AP-related protein1
gon-4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282856.2 → NP_001269785.1  GON-4-like protein isoform c

    See identical proteins and their annotated locations for NP_001269785.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 3 and 4 encode the same, longest protein (isoform c).
    Source sequence(s)
    AL139128, AL162734, AY335491, CN391065
    Consensus CDS
    CCDS60296.1
    UniProtKB/Swiss-Prot
    B7ZBL4, Q14C93, Q3T8J8, Q3T8J9, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6
    UniProtKB/TrEMBL
    A4PB67
    Related
    ENSP00000483100.1, ENST00000615926.4
    Conserved Domains (2) summary
    cd12202
    Location:2143 → 2208
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:1648 → 1693
    PAH; Paired amphipathic helix repeat

  2. NM_001282858.2 → NP_001269787.1  GON-4-like protein isoform a

    See identical proteins and their annotated locations for NP_001269787.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform a), compared to isoform c.
    Source sequence(s)
    AB195687, AL162734, BC064933, BC114629, CN391065
    Consensus CDS
    CCDS44242.1
    UniProtKB/TrEMBL
    A4PB67
    Related
    ENSP00000396117.1, ENST00000437809.5
    Conserved Domains (2) summary
    cd12202
    Location:2142 → 2207
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:1648 → 1693
    PAH; Paired amphipathic helix repeat

  3. NM_001282860.2 → NP_001269789.1  GON-4-like protein isoform c

    See identical proteins and their annotated locations for NP_001269789.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein. Variants 3 and 4 encode isoform (c).
    Source sequence(s)
    AL139128, AL162734
    Consensus CDS
    CCDS60296.1
    UniProtKB/Swiss-Prot
    B7ZBL4, Q14C93, Q3T8J8, Q3T8J9, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6
    UniProtKB/TrEMBL
    A4PB67
    Related
    ENSP00000357315.1, ENST00000368331.6
    Conserved Domains (2) summary
    cd12202
    Location:2143 → 2208
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:1648 → 1693
    PAH; Paired amphipathic helix repeat

  4. NM_001282861.2 → NP_001269790.1  GON-4-like protein isoform b

    See identical proteins and their annotated locations for NP_001269790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains a 3' terminal exon that extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AB195687, AI476308, AK022985, AL139128, BC036740, BC115703
    Consensus CDS
    CCDS1121.1
    UniProtKB/TrEMBL
    Q14BN2
    Related
    ENSP00000478593.2, ENST00000622608.2
    Conserved Domains (1) summary
    PHA03247
    Location:1007 → 1436
    PHA03247; large tegument protein UL36; Provisional

  5. NM_032292.6 → NP_115668.4  GON-4-like protein isoform b

    See identical proteins and their annotated locations for NP_115668.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains a 3' terminal exon that extends past a splice site in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AB195688, AI476308, AL139128, BC036740, BC114629
    Consensus CDS
    CCDS1121.1
    UniProtKB/TrEMBL
    Q14BN2
    Related
    ENSP00000354322.5, ENST00000361040.9
    Conserved Domains (1) summary
    PHA03247
    Location:1007 → 1436
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    155745112..155859431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423299.1 → XP_047279255.1  GON-4-like protein isoform X4

  2. XM_006711394.5 → XP_006711457.1  GON-4-like protein isoform X1

    See identical proteins and their annotated locations for XP_006711457.1

    UniProtKB/TrEMBL
    A4PB67
    Conserved Domains (2) summary
    cd12202
    Location:2142 → 2207
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:1648 → 1693
    PAH; Paired amphipathic helix repeat

  3. XM_047423284.1 → XP_047279240.1  GON-4-like protein isoform X2

  4. XM_047423298.1 → XP_047279254.1  GON-4-like protein isoform X4

  5. XM_006711393.4 → XP_006711456.1  GON-4-like protein isoform X1

    See identical proteins and their annotated locations for XP_006711456.1

    UniProtKB/TrEMBL
    A4PB67
    Conserved Domains (2) summary
    cd12202
    Location:2142 → 2207
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:1648 → 1693
    PAH; Paired amphipathic helix repeat

  6. XM_047423301.1 → XP_047279257.1  GON-4-like protein isoform X5

  7. XM_047423282.1 → XP_047279238.1  GON-4-like protein isoform X2

  8. XM_047423291.1 → XP_047279247.1  GON-4-like protein isoform X2

  9. XM_047423297.1 → XP_047279253.1  GON-4-like protein isoform X4

  10. XM_047423264.1 → XP_047279220.1  GON-4-like protein isoform X1

  11. XM_047423263.1 → XP_047279219.1  GON-4-like protein isoform X1

  12. XM_047423277.1 → XP_047279233.1  GON-4-like protein isoform X1

  13. XM_005245284.4 → XP_005245341.1  GON-4-like protein isoform X3

    See identical proteins and their annotated locations for XP_005245341.1

    UniProtKB/TrEMBL
    A4PB67
    Conserved Domains (2) summary
    cd12202
    Location:1970 → 2035
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:1476 → 1521
    PAH; Paired amphipathic helix repeat

  14. XM_047423296.1 → XP_047279252.1  GON-4-like protein isoform X3

  15. XM_005245286.4 → XP_005245343.1  GON-4-like protein isoform X7

    Conserved Domains (2) summary
    cd12202
    Location:1338 → 1403
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:844 → 889
    PAH; Paired amphipathic helix repeat

  16. XM_047423307.1 → XP_047279263.1  GON-4-like protein isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    154888528..154998299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337228.1 → XP_054193203.1  GON-4-like protein isoform X4

  2. XM_054337221.1 → XP_054193196.1  GON-4-like protein isoform X1

  3. XM_054337223.1 → XP_054193198.1  GON-4-like protein isoform X2

  4. XM_054337227.1 → XP_054193202.1  GON-4-like protein isoform X4

  5. XM_054337220.1 → XP_054193195.1  GON-4-like protein isoform X1

  6. XM_054337229.1 → XP_054193204.1  GON-4-like protein isoform X5

  7. XM_054337222.1 → XP_054193197.1  GON-4-like protein isoform X2

  8. XM_054337226.1 → XP_054193201.1  GON-4-like protein isoform X4

  9. XM_054337224.1 → XP_054193199.1  GON-4-like protein isoform X3

  10. XM_054337225.1 → XP_054193200.1  GON-4-like protein isoform X3

  11. XM_054337231.1 → XP_054193206.1  GON-4-like protein isoform X7

  12. XM_054337230.1 → XP_054193205.1  GON-4-like protein isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037533.1: Suppressed sequence

    Description
    NM_001037533.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

  2. NM_025174.1: Suppressed sequence

    Description
    NM_025174.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3T8J9.1 GenPept UniProtKB/Swiss-Prot:Q3T8J9

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