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QPCTL glutaminyl-peptide cyclotransferase like [ Homo sapiens (human) ]

Gene ID: 54814, updated on 7-Apr-2024

Summary

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Official Symbol
QPCTLprovided by HGNC
Official Full Name
glutaminyl-peptide cyclotransferase likeprovided by HGNC
Primary source
HGNC:HGNC:25952
See related
Ensembl:ENSG00000011478 AllianceGenome:HGNC:25952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
gQC
Summary
Enables glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Acts upstream of or within peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 3.4), prostate (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45692666..45703987)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48520206..48531526)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46195924..46207245)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10791 Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14811 Neighboring gene microRNA 642a Neighboring gene microRNA 642b Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46194747-46195467 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46196081-46196631 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14814 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46220214-46220884 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46220885-46221555 Neighboring gene F-box protein 46 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46223908-46224408 Neighboring gene Sharpr-MPRA regulatory regions 3721 and 14243 Neighboring gene Sharpr-MPRA regulatory region 6016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14817 Neighboring gene meiosis initiator Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46250835-46251627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46266800-46267354

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Deciphering the role of QPCTL in glioma progression and cancer immunotherapy. Liu Y, et al. Front Immunol, 2023. PMID 37063864, Free PMC Article
  2. Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Logtenberg MEW, et al. Nat Med, 2019 Apr. PMID 30833751, Free PMC Article
  3. Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis. Schloesser D, et al. J Cell Biol, 2023 Feb 6. PMID 36459066, Free PMC Article
  4. Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals. Burgdorf KS, et al. Diabetologia, 2012 Jan. PMID 21953277
  5. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. Huang KF, et al. J Biol Chem, 2011 Apr 8. PMID 21288892, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deciphering the role of QPCTL in glioma progression and cancer immunotherapy.
    Title: Deciphering the role of QPCTL in glioma progression and cancer immunotherapy.
  2. Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis.
    Title: Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis.
  3. QPCTL is critical for pyroglutamate formation on CD47 at the SIRPalpha binding site shortly after biosynthesis.
    Title: Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.
  4. genetic association studies in Danish population: Quantitative metabolic phenotypes in obesity are associated with SNP in various genes: QPCTL (rs2287019) is associated with body mass index and increased insulinogenic index.
    Title: Association studies of novel obesity-related gene variants with quantitative metabolic phenotypes in a population-based sample of 6,039 Danish individuals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Meta-analysis identifies common variants associated with body mass index in east Asians.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with QPCTL; predicted interaction to be within the Golgi PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutaminyl-peptide cyclotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminyl-peptide cyclotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
glutaminyl-peptide cyclotransferase-like protein
Names
glutaminyl cyclase-like
golgi-resident glutaminyl-peptide cyclotransferase
isoQC
NP_001156849.1
NP_060129.2
XP_011525350.1
XP_016882389.1
XP_047294953.1
XP_054177283.1
XP_054177284.1
XP_054177285.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163377.2 → NP_001156849.1  glutaminyl-peptide cyclotransferase-like protein isoform 2

    See identical proteins and their annotated locations for NP_001156849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC007191, AK222636, BC011553, BP216511
    Consensus CDS
    CCDS54282.1
    UniProtKB/Swiss-Prot
    Q9NXS2
    Related
    ENSP00000387944.2, ENST00000366382.8
    Conserved Domains (1) summary
    cl14876
    Location:116 → 285
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. NM_017659.4 → NP_060129.2  glutaminyl-peptide cyclotransferase-like protein isoform 1

    See identical proteins and their annotated locations for NP_060129.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007191, AK000091, AK222636, BC011553, BP216511
    Consensus CDS
    CCDS12672.1
    UniProtKB/Swiss-Prot
    Q53HE4, Q96F74, Q9NXS2
    Related
    ENSP00000012049.4, ENST00000012049.10
    Conserved Domains (1) summary
    cd03880
    Location:79 → 379
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    45692666..45703987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438997.1 → XP_047294953.1  glutaminyl-peptide cyclotransferase-like protein isoform X1

    UniProtKB/TrEMBL
    A0A7I2V5X1
    Related
    ENSP00000504501.1, ENST00000678862.1

  2. XM_017026900.2 → XP_016882389.1  glutaminyl-peptide cyclotransferase-like protein isoform X2

  3. XM_011527048.4 → XP_011525350.1  glutaminyl-peptide cyclotransferase-like protein isoform X3

    Conserved Domains (1) summary
    cl14876
    Location:79 → 191
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48520206..48531526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321308.1 → XP_054177283.1  glutaminyl-peptide cyclotransferase-like protein isoform X1

    UniProtKB/TrEMBL
    A0A7I2V5X1

  2. XM_054321309.1 → XP_054177284.1  glutaminyl-peptide cyclotransferase-like protein isoform X2

  3. XM_054321310.1 → XP_054177285.1  glutaminyl-peptide cyclotransferase-like protein isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NXS2.2 GenPept UniProtKB/Swiss-Prot:Q9NXS2

Gene LinkOut

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