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TRIM44 tripartite motif containing 44 [ Homo sapiens (human) ]

Gene ID: 54765, updated on 5-Mar-2024

Summary

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Official Symbol
TRIM44provided by HGNC
Official Full Name
tripartite motif containing 44provided by HGNC
Primary source
HGNC:HGNC:19016
See related
Ensembl:ENSG00000166326 MIM:612298; AllianceGenome:HGNC:19016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AN3; MC7; DIPB; HSA249128
Summary
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 26.6), thyroid (RPKM 23.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (35662775..35818007)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (35801539..35956748)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (35684323..35839557)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene peptidase domain containing associated with muscle regeneration 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3259 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:35639867-35640028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35640328-35640962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:35640963-35641597 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:35650952-35652151 Neighboring gene NANOG hESC enhancer GRCh37_chr11:35676186-35676747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:35684511-35685011 Neighboring gene four-jointed box kinase 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4627 Neighboring gene OCT4 hESC enhancer GRCh37_chr11:35774016-35774517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:35793100-35793607 Neighboring gene uncharacterized LOC124902661 Neighboring gene keratin 18 pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical Significance of TRIM44 Expression in Patients with Gastric Cancer. Goshayeshi L, et al. Asian Pac J Cancer Prev, 2022 May 1. PMID 35633558, Free PMC Article
  2. TRIM44 facilitates ovarian cancer proliferation, migration, and invasion by inhibiting FRK. Yu XZ, et al. Neoplasma, 2021 Jul. PMID 34034495
  3. Expression of tripartite motif-containing 44 and its prognostic and clinicopathological value in human malignancies:a meta-analysis. Xiao G, et al. BMC Cancer, 2020 Jun 5. PMID 32503466, Free PMC Article
  4. TRIM44 is indispensable for glioma cell proliferation and cell cycle progression through AKT/p21/p27 signaling pathway. Zhou X, et al. J Neurooncol, 2019 Nov. PMID 31605296
  5. High TRIM44 expression as a valuable biomarker for diagnosis and prognosis in cervical cancer. Liu S, et al. Biosci Rep, 2019 Mar 29. PMID 30792262, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis.
    Title: Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis.
  2. TRIM44 regulates tumor immunity in gastric cancer through LOXL2-dependent extracellular matrix remodeling.
    Title: TRIM44 regulates tumor immunity in gastric cancer through LOXL2-dependent extracellular matrix remodeling.
  3. Long noncoding RNA LINC00858 promotes the progression of ovarian cancer via regulating the miR-134-5p/TRIM44 axis.
    Title: Long noncoding RNA LINC00858 promotes the progression of ovarian cancer via regulating the miR-134-5p/TRIM44 axis.
  4. CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44.
    Title: CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44.
  5. Clinical Significance of TRIM44 Expression in Patients with Gastric Cancer.
    Title: Clinical Significance of TRIM44 Expression in Patients with Gastric Cancer.
  6. TRIM44 promotes BRCA1 functions in HR repair to induce Cisplatin Chemoresistance in Lung Adenocarcinoma by Deubiquitinating FLNA.
    Title: TRIM44 promotes BRCA1 functions in HR repair to induce Cisplatin Chemoresistance in Lung Adenocarcinoma by Deubiquitinating FLNA.
  7. YTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44.
    Title: YTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44.
  8. Knockdown of circRAD23B Exerts Antitumor Response in Colorectal Cancer via the Regulation of miR-1205/TRIM44 axis.
    Title: Knockdown of circRAD23B Exerts Antitumor Response in Colorectal Cancer via the Regulation of miR-1205/TRIM44 axis.
  9. TRIM44 mediated p62 deubiquitination enhances DNA damage repair by increasing nuclear FLNA and 53BP1 expression.
    Title: TRIM44 mediated p62 deubiquitination enhances DNA damage repair by increasing nuclear FLNA and 53BP1 expression.
  10. MiR-34a-5p directly targeting TRIM44 affects the biological behavior of ovarian cancer cells.
    Title: MiR-34a-5p directly targeting TRIM44 affects the biological behavior of ovarian cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Aniridia 3
MedGen: C4310695 OMIM: 617142 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genomewide association study of movement-related adverse antipsychotic effects.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 44 (TRIM44) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3490

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to angiotensin IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052784.1 RefSeqGene

    Range
    5061..153362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017583.6 → NP_060053.2  tripartite motif-containing protein 44

    See identical proteins and their annotated locations for NP_060053.2

    Status: REVIEWED

    Source sequence(s)
    AC090692, AK074242, BI222592, BI550863, BQ014398, CA445350, CX788887, CX871447, DA128342, DA131915, DA158251
    Consensus CDS
    CCDS31461.1
    UniProtKB/Swiss-Prot
    D3DR14, Q96DX7, Q96QY2, Q9UGK0
    Related
    ENSP00000299413.5, ENST00000299413.7
    Conserved Domains (2) summary
    cd19784
    Location:177 → 215
    Bbox2_TRIM44; B-box-type 2 zinc finger found in tripartite motif-containing protein 44 (TRIM44) and similar proteins
    cd19841
    Location:15 → 60
    Bbox1_TRIM44; B-box-type 1 zinc finger found in tripartite motif-containing protein 44 (TRIM44) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    35662775..35818007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718254.2 → XP_006718317.1  tripartite motif-containing protein 44 isoform X1

    Conserved Domains (1) summary
    pfam00643
    Location:177 → 215
    zf-B_box; B-box zinc finger

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    35801539..35956748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369171.1 → XP_054225146.1  tripartite motif-containing protein 44 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DX7.1 GenPept UniProtKB/Swiss-Prot:Q96DX7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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