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FBLIM1 filamin binding LIM protein 1 [ Homo sapiens (human) ]

Gene ID: 54751, updated on 5-Mar-2024

Summary

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Official Symbol
FBLIM1provided by HGNC
Official Full Name
filamin binding LIM protein 1provided by HGNC
Primary source
HGNC:HGNC:24686
See related
Ensembl:ENSG00000162458 MIM:607747; AllianceGenome:HGNC:24686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAL; FBLP1; FBLP-1
Summary
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 17.5), colon (RPKM 14.6) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
1p36.21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (15756638..15786589)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (15201378..15231333)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16083133..16113084)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SLC25A34 and TMEM82 antisense RNA 1 Neighboring gene solute carrier family 25 member 34 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16068575-16069355 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16070316-16070829 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16070830-16071342 Neighboring gene transmembrane protein 82 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16079899-16080400 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16080401-16080900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16082643-16083422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16087099-16088043 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16112886-16113650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:16113651-16114415 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:16118272-16118772 Neighboring gene ribosomal protein L12 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 12316 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:16130189-16130690 Neighboring gene ubiquinol-cytochrome c reductase hinge protein like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High prevalence of rare FBLIM1 gene variants in an Italian cohort of patients with Chronic Non-bacterial Osteomyelitis (CNO). d'Adamo AP, et al. Pediatr Rheumatol Online J, 2020 Jul 10. PMID 32650789, Free PMC Article
  2. Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups. Assmann G, et al. BMC Med Genet, 2020 May 12. PMID 32397996, Free PMC Article
  3. FBLIM1 enhances oral cancer malignancy via modulation of the epidermal growth factor receptor pathway. Toeda Y, et al. Mol Carcinog, 2018 Dec. PMID 30129678
  4. Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO). Cox AJ, et al. PLoS One, 2017. PMID 28301468, Free PMC Article
  5. Migfilin's elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via β-catenin upregulation. Gkretsi V, et al. Biochem Biophys Res Commun, 2013 Jan 11. PMID 23237804, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High prevalence of rare FBLIM1 gene variants in an Italian cohort of patients with Chronic Non-bacterial Osteomyelitis (CNO).
    Title: High prevalence of rare FBLIM1 gene variants in an Italian cohort of patients with Chronic Non-bacterial Osteomyelitis (CNO).
  2. Genetic analyses of FBLIM1 did not provide evidence that this gene is relevant in our patient group. Our study indicates the need to elucidate SAPHO's and CRMO/CNO's pathogenesis.
    Title: Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups.
  3. Findings indicate that tightly regulated expression of migfilin is essential for neuronal development and that FBLIM1 disruption may be related to the phenotypes associated with ASD and related neurodevelopmental disorders.
    Title: Possible involvement of a cell adhesion molecule, Migfilin, in brain development and pathogenesis of autism spectrum disorders.
  4. Results showed FBLIM1 overexpression in oral squamous cell carcinoma (OSCC) in vitro and in vivo and that FBLIM1 positivity in OSCC was correlated with tumoral growth and vascular invasion. FBLIM1 silencing was characterized by decreased cellular growth, invasiveness, and migratory activities and induced EGFR down-regulation.
    Title: FBLIM1 enhances oral cancer malignancy via modulation of the epidermal growth factor receptor pathway.
  5. Authors conclude that circFBLIM1 may function as a competing endogenous RNA (ceRNA) to regulate FBLIM1 expression through sponging miR-346 to exert regulatory functions in HCC.
    Title: circFBLIM1 act as a ceRNA to promote hepatocellular cancer progression by sponging miR-346.
  6. Migfilin promotes migration and invasion in glioma by driving EGFR and MMP-2 signalings
    Title: Migfilin promotes migration and invasion in glioma by driving EGFR and MMP-2 signalings: A positive feedback loop regulation.
  7. data implicate FBLIM1 in the pathogenesis of sterile bone inflammation and our findings suggest CRMO is a disorder of chronic inflammation and imbalanced bone remodeling
    Title: Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO).
  8. the present study emphasizes for the first time to our knowledge the role of Migfilin in osteoarthritis(OA) and highlights the importance of cell-ECM adhesion proteins in OA pathogenesis.
    Title: Migfilin's elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via β-catenin upregulation.
  9. Migfilin expression is reduced in breast cancer.
    Title: Mitogen-inducible Gene-2 (MIG2) and migfilin expression is reduced in samples of human breast cancer.
  10. alpha-parvin, beta-parvin and migfilin were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively.
    Title: Migfilin, α-parvin and β-parvin are differentially expressed in ovarian serous carcinoma effusions, primary tumors and solid metastases.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of filamin binding LIM protein 1 (FBLIM1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434G171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables filamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables filamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of integrin activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
filamin-binding LIM protein 1
Names
CSX-associated LIM
MIG2-interacting protein
migfilin
mitogen-inducible 2 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024215.1 → NP_001019386.1  filamin-binding LIM protein 1 isoform b

    See identical proteins and their annotated locations for NP_001019386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons and contains an extra segment with an early stop codon, compared to variant 1. The encoded protein (isoform b) is longer and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF459643, AL450998, CN278745
    Consensus CDS
    CCDS44064.1
    UniProtKB/Swiss-Prot
    Q8WUP2
    Related
    ENSP00000416387.2, ENST00000441801.6
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001024216.3 → NP_001019387.1  filamin-binding LIM protein 1 isoform c

    See identical proteins and their annotated locations for NP_001019387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AK027444, AK055259, AL133035, AW069718
    Consensus CDS
    CCDS30609.1
    UniProtKB/Swiss-Prot
    Q8WUP2
    Related
    ENSP00000364920.2, ENST00000332305.5
    Conserved Domains (2) summary
    cd09372
    Location:146 → 198
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:206 → 267
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. NM_001350151.2 → NP_001337080.1  filamin-binding LIM protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same protein (isoform a).
    Source sequence(s)
    AL133035, AL450998, AW069718, BC019895
    Consensus CDS
    CCDS163.1
    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6
    Related
    ENSP00000364926.1, ENST00000375771.5
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:303 → 364
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. NM_017556.4 → NP_060026.2  filamin-binding LIM protein 1 isoform a

    See identical proteins and their annotated locations for NP_060026.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 4 encode the same protein (isoform a).
    Source sequence(s)
    AK055259, AL133035, AW069718
    Consensus CDS
    CCDS163.1
    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6
    Related
    ENSP00000364921.3, ENST00000375766.8
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:303 → 364
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    15756638..15786589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423104.1 → XP_047279060.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  2. XM_011541617.3 → XP_011539919.1  filamin-binding LIM protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011539919.1

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:303 → 364
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_047423129.1 → XP_047279085.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  4. XM_047423148.1 → XP_047279104.1  filamin-binding LIM protein 1 isoform X4

  5. XM_047423110.1 → XP_047279066.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  6. XM_047423162.1 → XP_047279118.1  filamin-binding LIM protein 1 isoform X5

  7. XM_017001526.3 → XP_016857015.1  filamin-binding LIM protein 1 isoform X5

  8. XM_047423159.1 → XP_047279115.1  filamin-binding LIM protein 1 isoform X5

  9. XM_005245903.2 → XP_005245960.1  filamin-binding LIM protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005245960.1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  10. XM_006710705.2 → XP_006710768.1  filamin-binding LIM protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006710768.1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  11. XM_017001521.3 → XP_016857010.1  filamin-binding LIM protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  12. XM_017001519.3 → XP_016857008.1  filamin-binding LIM protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  13. XM_006710704.4 → XP_006710767.1  filamin-binding LIM protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006710767.1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  14. XM_017001520.3 → XP_016857009.1  filamin-binding LIM protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  15. XM_011541616.3 → XP_011539918.1  filamin-binding LIM protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011539918.1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  16. XM_017001525.2 → XP_016857014.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cl02475
    Location:303 → 364
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  17. XM_047423112.1 → XP_047279068.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  18. XM_047423149.1 → XP_047279105.1  filamin-binding LIM protein 1 isoform X4

  19. XM_047423133.1 → XP_047279089.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  20. XM_047423116.1 → XP_047279072.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  21. XM_047423128.1 → XP_047279084.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  22. XM_047423151.1 → XP_047279107.1  filamin-binding LIM protein 1 isoform X4

  23. XM_047423138.1 → XP_047279094.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  24. XM_005245902.2 → XP_005245959.1  filamin-binding LIM protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005245959.1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  25. XM_047423123.1 → XP_047279079.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  26. XM_047423158.1 → XP_047279114.1  filamin-binding LIM protein 1 isoform X4

  27. XM_047423143.1 → XP_047279099.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  28. XM_047423152.1 → XP_047279108.1  filamin-binding LIM protein 1 isoform X4

  29. XM_047423150.1 → XP_047279106.1  filamin-binding LIM protein 1 isoform X4

  30. XM_047423141.1 → XP_047279097.1  filamin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B3KNY0, Q5VVE0, Q5VVE1, Q8IX23, Q8WUP2, Q96T00, Q9UFD6

  31. XM_047423156.1 → XP_047279112.1  filamin-binding LIM protein 1 isoform X4

  32. XM_047423172.1 → XP_047279128.1  filamin-binding LIM protein 1 isoform X5

  33. XM_047423176.1 → XP_047279132.1  filamin-binding LIM protein 1 isoform X5

  34. XM_047423147.1 → XP_047279103.1  filamin-binding LIM protein 1 isoform X3

  35. XM_047423175.1 → XP_047279131.1  filamin-binding LIM protein 1 isoform X5

  36. XM_005245900.2 → XP_005245957.1  filamin-binding LIM protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005245957.1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  37. XM_017001523.2 → XP_016857012.1  filamin-binding LIM protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  38. XM_005245901.2 → XP_005245958.1  filamin-binding LIM protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005245958.1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  39. XM_017001524.2 → XP_016857013.1  filamin-binding LIM protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8WUP2
    Conserved Domains (2) summary
    cd09372
    Location:243 → 295
    LIM2_FBLP-1; The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
    cd08368
    Location:183 → 236
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    15201378..15231333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337177.1 → XP_054193152.1  filamin-binding LIM protein 1 isoform X2

  2. XM_054337185.1 → XP_054193160.1  filamin-binding LIM protein 1 isoform X2

  3. XM_054337191.1 → XP_054193166.1  filamin-binding LIM protein 1 isoform X4

  4. XM_054337200.1 → XP_054193175.1  filamin-binding LIM protein 1 isoform X5

  5. XM_054337198.1 → XP_054193173.1  filamin-binding LIM protein 1 isoform X5

  6. XM_054337199.1 → XP_054193174.1  filamin-binding LIM protein 1 isoform X5

  7. XM_054337168.1 → XP_054193143.1  filamin-binding LIM protein 1 isoform X1

  8. XM_054337170.1 → XP_054193145.1  filamin-binding LIM protein 1 isoform X1

  9. XM_054337175.1 → XP_054193150.1  filamin-binding LIM protein 1 isoform X1

  10. XM_054337173.1 → XP_054193148.1  filamin-binding LIM protein 1 isoform X1

  11. XM_054337165.1 → XP_054193140.1  filamin-binding LIM protein 1 isoform X1

  12. XM_054337174.1 → XP_054193149.1  filamin-binding LIM protein 1 isoform X1

  13. XM_054337167.1 → XP_054193142.1  filamin-binding LIM protein 1 isoform X1

  14. XM_054337178.1 → XP_054193153.1  filamin-binding LIM protein 1 isoform X2

  15. XM_054337179.1 → XP_054193154.1  filamin-binding LIM protein 1 isoform X2

  16. XM_054337181.1 → XP_054193156.1  filamin-binding LIM protein 1 isoform X2

  17. XM_054337171.1 → XP_054193146.1  filamin-binding LIM protein 1 isoform X1

  18. XM_054337182.1 → XP_054193157.1  filamin-binding LIM protein 1 isoform X2

  19. XM_054337192.1 → XP_054193167.1  filamin-binding LIM protein 1 isoform X4

  20. XM_054337194.1 → XP_054193169.1  filamin-binding LIM protein 1 isoform X4

  21. XM_054337180.1 → XP_054193155.1  filamin-binding LIM protein 1 isoform X2

  22. XM_054337184.1 → XP_054193159.1  filamin-binding LIM protein 1 isoform X2

  23. XM_054337186.1 → XP_054193161.1  filamin-binding LIM protein 1 isoform X2

  24. XM_054337187.1 → XP_054193162.1  filamin-binding LIM protein 1 isoform X2

  25. XM_054337183.1 → XP_054193158.1  filamin-binding LIM protein 1 isoform X2

  26. XM_054337197.1 → XP_054193172.1  filamin-binding LIM protein 1 isoform X4

  27. XM_054337189.1 → XP_054193164.1  filamin-binding LIM protein 1 isoform X2

  28. XM_054337195.1 → XP_054193170.1  filamin-binding LIM protein 1 isoform X4

  29. XM_054337193.1 → XP_054193168.1  filamin-binding LIM protein 1 isoform X4

  30. XM_054337188.1 → XP_054193163.1  filamin-binding LIM protein 1 isoform X2

  31. XM_054337196.1 → XP_054193171.1  filamin-binding LIM protein 1 isoform X4

  32. XM_054337201.1 → XP_054193176.1  filamin-binding LIM protein 1 isoform X5

  33. XM_054337203.1 → XP_054193178.1  filamin-binding LIM protein 1 isoform X5

  34. XM_054337190.1 → XP_054193165.1  filamin-binding LIM protein 1 isoform X3

  35. XM_054337202.1 → XP_054193177.1  filamin-binding LIM protein 1 isoform X5

  36. XM_054337166.1 → XP_054193141.1  filamin-binding LIM protein 1 isoform X1

  37. XM_054337176.1 → XP_054193151.1  filamin-binding LIM protein 1 isoform X1

  38. XM_054337169.1 → XP_054193144.1  filamin-binding LIM protein 1 isoform X1

  39. XM_054337172.1 → XP_054193147.1  filamin-binding LIM protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WUP2.2 GenPept UniProtKB/Swiss-Prot:Q8WUP2

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