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Zc3h12b zinc finger CCCH-type containing 12B [ Mus musculus (house mouse) ]

Gene ID: 547176, updated on 30-Apr-2024

Summary

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Official Symbol
Zc3h12bprovided by MGI
Official Full Name
zinc finger CCCH-type containing 12Bprovided by MGI
Primary source
MGI:MGI:2442133
See related
Ensembl:ENSMUSG00000035045 AllianceGenome:MGI:2442133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm373; CXorf32; A130028J20Rik
Summary
Predicted to enable endoribonuclease activity and mRNA binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12B (zinc finger CCCH-type containing 12B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 1.7), cortex adult (RPKM 1.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X C3; X 42.14 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (94755206..94976262)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (95711583..95932656)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene adenylosuccinate lyase pseudogene Neighboring gene predicted gene, 29889 Neighboring gene RIKEN cDNA 1700010D01 gene Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47575 Neighboring gene LAS1-like (S. cerevisiae) Neighboring gene predicted gene, 41897 Neighboring gene eukaryotic translation initiation factor 4B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. Liang J, et al. J Biol Chem, 2008 Mar 7. PMID 18178554
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.
    Title: A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • KIAA0615

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ribonuclease ZC3H12B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034907.3 → NP_001030079.2  probable ribonuclease ZC3H12B

    See identical proteins and their annotated locations for NP_001030079.2

    Status: VALIDATED

    Source sequence(s)
    AK134628, AL732438, BX005184
    Consensus CDS
    CCDS41069.1
    UniProtKB/TrEMBL
    G3X9I7
    Related
    ENSMUSP00000080820.7, ENSMUST00000082183.8
    Conserved Domains (4) summary
    cd18729
    Location:192 → 322
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:107 → 148
    UBA_6; UBA-like domain
    pfam18044
    Location:359 → 377
    zf-CCCH_4; CCCH-type zinc finger
    pfam18561
    Location:795 → 829
    Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    94755206..94976262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247643.4 → XP_011245945.1  probable ribonuclease ZC3H12B isoform X3

    Conserved Domains (3) summary
    cd18729
    Location:192 → 322
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:107 → 148
    UBA_6; UBA-like domain
    pfam18044
    Location:359 → 377
    zf-CCCH_4; CCCH-type zinc finger

  2. XM_011247641.4 → XP_011245943.1  probable ribonuclease ZC3H12B isoform X1

    See identical proteins and their annotated locations for XP_011245943.1

    UniProtKB/TrEMBL
    G3X9I7
    Conserved Domains (4) summary
    cd18729
    Location:192 → 322
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:107 → 148
    UBA_6; UBA-like domain
    pfam18044
    Location:359 → 377
    zf-CCCH_4; CCCH-type zinc finger
    pfam18561
    Location:795 → 829
    Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain

  3. XM_011247642.4 → XP_011245944.1  probable ribonuclease ZC3H12B isoform X2

    Conserved Domains (3) summary
    cd18729
    Location:192 → 322
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:107 → 148
    UBA_6; UBA-like domain
    pfam18044
    Location:359 → 377
    zf-CCCH_4; CCCH-type zinc finger

  4. XM_011247640.2 → XP_011245942.1  probable ribonuclease ZC3H12B isoform X1

    See identical proteins and their annotated locations for XP_011245942.1

    UniProtKB/TrEMBL
    G3X9I7
    Conserved Domains (4) summary
    cd18729
    Location:192 → 322
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:107 → 148
    UBA_6; UBA-like domain
    pfam18044
    Location:359 → 377
    zf-CCCH_4; CCCH-type zinc finger
    pfam18561
    Location:795 → 829
    Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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