Plagl2 pleiomorphic adenoma gene-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plagl2provided by MGI
Official Full Name: pleiomorphic adenoma gene-like 2provided by MGI
Primary source: MGI:MGI:1933165
See related: Ensembl:ENSMUSG00000051413 AllianceGenome:MGI:1933165
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0198
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within several processes, including chylomicron assembly; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human PLAGL2 (PLAG1 like zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14.5 (RPKM 11.2), thymus adult (RPKM 10.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 75.41 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (153069689..153083278, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (153227769..153241358, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLAGL2 induces nucleus pulposus cell apoptosis via regulating RASSF5 expression and thus accelerates intervertebral disc degeneration.
Title: PLAGL2 induces nucleus pulposus cell apoptosis via regulating RASSF5 expression and thus accelerates intervertebral disc degeneration.
PLAGL2 expression is strongly associated with an IESC signature in colorectal cancer and may be responsible for contributing to the aberrant activation of an immature phenotype.
Title: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells.
expression is associated with the development of lung adenocarcinoma and emphysema
Title: Pleiomorphic adenoma gene-like 2 expression is associated with the development of lung adenocarcinoma and emphysema.
Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling
Title: PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas.
Increased cell injury and/or death could be caused directly by the upregulation of bNip3, a preapoptotic molecule that dimerizes with Bcl-2, or indirectly by the aberrant expression of SP-C-induced endoplasmic reticulum stress in epithelial cells.
Title: PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity.
PlagL2 regulates important aspects of dietary lipid absorption, and the PlagL2(-/-) animal model has implications for the amelioration of obesity and the metabolic syndrome.
Title: Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.
induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis.
Title: A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plagl2 (e-PCR), detects polymorphism
- UniSTS:472871

RH136245 (e-PCR)
- UniSTS:210239

AW552839 (e-PCR)
- UniSTS:178761

NoName (e-PCR)
- UniSTS:548428

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chylomicron assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein PLAGL2

Names: pleomorphic adenoma gene like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018807.5 → NP_061277.2 zinc finger protein PLAGL2

See identical proteins and their annotated locations for NP_061277.2

Status: PROVISIONAL

Source sequence(s)

AL807380

Consensus CDS

CCDS16908.1

UniProtKB/TrEMBL

Q3UZI7, Q925T4

Related

ENSMUSP00000055709.8, ENSMUST00000056924.14

Conserved Domains (2) summary

sd00017
Location:70 → 92

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:85 → 109

zf-H2C2_2; Zinc-finger double domain