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Hs3st3b1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 [ Mus musculus (house mouse) ]

Gene ID: 54710, updated on 8-Feb-2024

Summary

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Official Symbol
Hs3st3b1provided by MGI
Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1provided by MGI
Primary source
MGI:MGI:1333853
See related
Ensembl:ENSMUSG00000070407 AllianceGenome:MGI:1333853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3Ost3b; 3OST3B1; Hs3st3b; 3-OST-3B; m3-OST-3B
Summary
Enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Acts upstream of or within protein sulfation. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and respiratory system. Orthologous to human HS3ST3B1 (heparan sulfate-glucosamine 3-sulfotransferase 3B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 31.6), liver adult (RPKM 20.3) and 18 other tissues See more
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Genomic context

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See Hs3st3b1 in Genome Data Viewer
Location:
11 B3; 11 39.47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (63775519..63813110, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (63884693..63922284, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 1 pseudogene Neighboring gene high mobility group box 1, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_29739 Neighboring gene STARR-seq mESC enhancer starr_29740 Neighboring gene STARR-positive B cell enhancer ABC_E1420 Neighboring gene STARR-seq mESC enhancer starr_29745 Neighboring gene STARR-seq mESC enhancer starr_29746 Neighboring gene RIKEN cDNA 9630013K17 gene Neighboring gene predicted gene, 30060 Neighboring gene heme A:farnesyltransferase cytochrome c oxidase assembly factor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of the Expression of Heparan Sulfate 3-O-Sulfotransferase 3B (HS3ST3B) by Inflammatory Stimuli in Human Monocytes. Sikora AS, et al. J Cell Biochem, 2016 Jul. PMID 26575945
  2. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Shukla D, et al. Cell, 1999 Oct 1. PMID 10520990
  3. Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney. Rutledge EA, et al. Dev Dyn, 2020 Jun. PMID 32017326, Free PMC Article
  4. Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain. Yabe T, et al. Glycobiology, 2005 Oct. PMID 15944372
  5. FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands. Chen Z, et al. Development, 2014 Jul. PMID 24924191, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.
    Title: Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.
  2. findings indicate that HS3ST3B1 gene behaves as a primary response gene, suggesting that it may play an important role in making 3-O-sulfated HS with specific functions in the regulation of inflammatory and immune responses.
    Title: Regulation of the Expression of Heparan Sulfate 3-O-Sulfotransferase 3B (HS3ST3B) by Inflammatory Stimuli in Human Monocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
Inferred from Sequence Orthology
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 3B1
Names
D-glycosaminyl 3-O-sulfotransferase-3B
heparan sulfate 3-O-sulfotransferase 3B1
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1
NP_061275.2
XP_030102020.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018805.2 → NP_061275.2  heparan sulfate glucosamine 3-O-sulfotransferase 3B1

    See identical proteins and their annotated locations for NP_061275.2

    Status: VALIDATED

    Source sequence(s)
    AK085242, AL603889
    Consensus CDS
    CCDS24838.1
    UniProtKB/Swiss-Prot
    Q5NCR0, Q9QZS6
    UniProtKB/TrEMBL
    Q3TA92
    Related
    ENSMUSP00000091647.4, ENSMUST00000094103.4
    Conserved Domains (1) summary
    pfam00685
    Location:137 → 374
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    63775519..63813110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246160.1 → XP_030102020.1  heparan sulfate glucosamine 3-O-sulfotransferase 3B1 isoform X1

    Conserved Domains (1) summary
    pfam00685
    Location:1 → 187
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZS6.2 GenPept UniProtKB/Swiss-Prot:Q9QZS6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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