Calhm1 calcium homeostasis modulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calhm1provided by MGI
Official Full Name: calcium homeostasis modulator 1provided by MGI
Primary source: MGI:MGI:3643383
See related: Ensembl:ENSMUSG00000079258 AllianceGenome:MGI:3643383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG546729
Summary: Enables voltage-gated calcium channel activity. Involved in ATP transport; protein heterooligomerization; and sensory perception of taste. Located in basolateral plasma membrane. Is expressed in ductus deferens; epididymis; esophagus; ileum; and tongue. Orthologous to human CALHM1 (calcium homeostasis modulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 19 C3; 19 39.36 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (47129474..47132613, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (47141035..47144174, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.
Title: Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.
Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel.
Title: Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel.
CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.
Title: CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.
CALHM3, together with CALHM1, is essential to form the fast voltage-gated ATP-release channel in taste bud cells required for taste.
Title: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes.
CALHM1 may be another taste receptor besides CD36 that contributes to fat detection and preference.
Title: Greater reductions in fat preferences in CALHM1 than CD36 knockout mice.
These results show that CALHM1 channels mediate postanoxic depolarization in neurons and brain damage after ischemia.
Title: Blockade and knock-out of CALHM1 channels attenuate ischemic brain damage.
CALHM1 plays a newly defined role, complementary to PANX1, in ATP release and downstream ciliary beat frequency modulation.
Title: CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells.
CALHM1 gating and association with lipid microdomains are post-translationally regulated through the process of protein S-palmitoylation.
Title: Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel.
Calhm1 deletion changes activation kinetics of large voltage-gated outward currents and their associated nonselective tail currents in taste bud cells. Calhm1 deletion reduced the half-widths of action potentials and accelerated the deactivation kinetics of transient outward currents in taste bud cells.
Title: Action potentials and ion conductances in wild-type and CALHM1-knockout type II taste cells.
Thus, CALHM1 controls synaptic activity in cerebral neurons and is required for the flexible processing of memory in mice.
Title: CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein heterooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of bitter taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sweet taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of umami taste	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: calcium homeostasis modulator protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.