Adgrg3 adhesion G protein-coupled receptor G3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgrg3provided by MGI
Official Full Name: adhesion G protein-coupled receptor G3provided by MGI
Primary source: MGI:MGI:1859670
See related: Ensembl:ENSMUSG00000060470 AllianceGenome:MGI:1859670
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pb1; Pb99; Gpr97; A030001G24Rik
Summary: Predicted to enable G protein-coupled receptor activity. Involved in B cell differentiation; negative regulation of CREB transcription factor activity; and negative regulation of NIK/NF-kappaB signaling. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human ADGRG3 (adhesion G protein-coupled receptor G3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 6.7), liver E18 (RPKM 4.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 47.12 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95743742..95771878)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (95017113..95045250)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation.
Title: Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation.
Results show that G protein-coupled receptor 97 protein (Gpr97) plays an important role in the development of experimental autoimmune encephalomyelitis (EAE) and may have a therapeutic potential for the treatment of central nervous system (CNS) autoimmunity.
Title: Gpr97/Adgrg3 ameliorates experimental autoimmune encephalomyelitis by regulating cytokine expression.
Our findings imply that Gpr97 might not be required for the development of airway inflammation in OVA-induced allergic asthma in mice.
Title: Gpr97 Is Dispensable for Inflammation in OVA-Induced Asthmatic Mice.
The GPR92 is expressed in the majority of T1R1-positive taste cells.
Title: Gustatory sensory cells express a receptor responsive to protein breakdown products (GPR92).
Gpr97 deficiency results in an extensive reduction in B220(+) lymphocytes in mice.
Title: Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision.
a possible role of GPR97 in lymphatic remodeling
Title: The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42.
Data demonstrate that the pre-B-cell receptor is essential for monoallelic silencing of VpreB and lambda5 at the large pre-BII-cell stage.
Title: The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AW214383 (e-PCR)
- UniSTS:179792

05.MMHAP40FRB8.seq (e-PCR)
- UniSTS:122814

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of CREB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: adhesion G protein-coupled receptor G3

Names: G 97; G-protein coupled receptor 97; pre B-cell transcription factor 1; probable G-protein coupled receptor 97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173036.3 → NP_766624.3 adhesion G protein-coupled receptor G3 precursor

See identical proteins and their annotated locations for NP_766624.3

Status: VALIDATED

Source sequence(s)

AC103935, BC064726

Consensus CDS

CCDS22554.1

UniProtKB/Swiss-Prot

Q3U2Q3, Q8R0T6

UniProtKB/TrEMBL

Q3U3P6

Related

ENSMUSP00000051079.9, ENSMUST00000051259.10

Conserved Domains (2) summary

pfam01825
Location:211 → 250

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:262 → 509

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

95743742..95771878

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531198.4 → XP_006531261.1 adhesion G protein-coupled receptor G3 isoform X1

UniProtKB/TrEMBL

Q3U3P6

Conserved Domains (3) summary

cd14964
Location:213 → 238

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:163 → 201

GPS; GPCR proteolysis site, GPS, motif

cl28897
Location:211 → 479

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006531199.5 → XP_006531262.1 adhesion G protein-coupled receptor G3 isoform X2

UniProtKB/TrEMBL

Q3U3P6

Conserved Domains (3) summary

cd14964
Location:181 → 206

7tm_GPCRs; TM helix 1 [structural motif]

pfam01825
Location:131 → 169

GPS; GPCR proteolysis site, GPS, motif

cl28897
Location:179 → 447

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036154188.1 → XP_036010081.1 adhesion G protein-coupled receptor G3 isoform X3

Conserved Domains (3) summary

pfam01825
Location:21 → 59

GPS; GPCR proteolysis site, GPS, motif

cd14964
Location:71 → 96

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:69 → 337

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

XR_387760.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_025309.1: Suppressed sequence

Description

NM_025309.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.