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Atp8b2 ATPase, class I, type 8B, member 2 [ Mus musculus (house mouse) ]

Gene ID: 54667, updated on 21-Apr-2024

Summary

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Official Symbol
Atp8b2provided by MGI
Official Full Name
ATPase, class I, type 8B, member 2provided by MGI
Primary source
MGI:MGI:1859660
See related
Ensembl:ENSMUSG00000060671 AllianceGenome:MGI:1859660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Id
Summary
Predicted to enable phosphatidylcholine flippase activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to act upstream of or within lipid transport. Predicted to be located in Golgi apparatus. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including hindbrain; limb; sensory organ; skeleton; and ventral grey horn. Orthologous to human ATP8B2 (ATPase phospholipid transporting 8B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 20.9), limb E14.5 (RPKM 18.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 39.19 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89846795..89870645, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89939481..89963338, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene src homology 2 domain-containing transforming protein E Neighboring gene STARR-positive B cell enhancer ABC_E9217 Neighboring gene STARR-positive B cell enhancer ABC_E4556 Neighboring gene interleukin 6 receptor, alpha Neighboring gene STARR-seq mESC enhancer starr_08265 Neighboring gene STARR-positive B cell enhancer ABC_E2670 Neighboring gene STARR-seq mESC enhancer starr_08266 Neighboring gene STARR-positive B cell enhancer ABC_E7921 Neighboring gene STARR-positive B cell enhancer ABC_E7922 Neighboring gene aquaporin 10, pseudogene Neighboring gene predicted gene, 24046 Neighboring gene STARR-positive B cell enhancer ABC_E4557 Neighboring gene HCLS1 associated X-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MIDA1, a protein associated with Id, regulates cell growth. Shoji W, et al. J Biol Chem, 1995 Oct 20. PMID 7559602
  2. Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors. Meier-Stiegen F, et al. PLoS One, 2010 Jul 8. PMID 20628604, Free PMC Article
  3. A trans-eQTL network regulates osteoclast multinucleation and bone mass. Pereira M, et al. Elife, 2020 Jun 19. PMID 32553114, Free PMC Article
  4. Differential expression of putative transbilayer amphipath transporters. Halleck MS, et al. Physiol Genomics, 1999 Nov 11. PMID 11015572
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Notch1 activates the expression of regulatory transcription factors such as Sox9, Pax6, Runx1, Myf5 and Id proteins that are critically involved in lineage decisions in the absence of protein synthesis.
    Title: Activated Notch1 target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase ID
Names
Atpase 8B2, p type
P4-ATPase flippase complex alpha subunit ATP8B2
probable phospholipid-transporting ATPase ID
NP_001074651.2
NP_001355579.1
XP_006501778.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081182.3 → NP_001074651.2  phospholipid-transporting ATPase ID isoform 2

    See identical proteins and their annotated locations for NP_001074651.2

    Status: VALIDATED

    Source sequence(s)
    AC163616
    Consensus CDS
    CCDS38497.2
    UniProtKB/TrEMBL
    D3YXQ5, E9QAL4
    Related
    ENSMUSP00000128423.2, ENSMUST00000168276.8
    Conserved Domains (1) summary
    cd02073
    Location:31 → 972
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  2. NM_001368650.2 → NP_001355579.1  phospholipid-transporting ATPase ID isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163616
    Consensus CDS
    CCDS89658.1
    UniProtKB/Swiss-Prot
    P98199
    UniProtKB/TrEMBL
    D3YXQ5
    Related
    ENSMUSP00000063384.8, ENSMUST00000069805.14
    Conserved Domains (1) summary
    cd02073
    Location:50 → 991
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89846795..89870645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501715.4 → XP_006501778.1  phospholipid-transporting ATPase ID isoform X1

    See identical proteins and their annotated locations for XP_006501778.1

    UniProtKB/TrEMBL
    D3YXQ5, E9QAL4
    Conserved Domains (1) summary
    cd02073
    Location:31 → 972
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98199.2 GenPept UniProtKB/Swiss-Prot:P98199

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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