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Usp27x ubiquitin specific peptidase 27, X chromosome [ Mus musculus (house mouse) ]

Gene ID: 54651, updated on 5-Mar-2024

Summary

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Official Symbol
Usp27xprovided by MGI
Official Full Name
ubiquitin specific peptidase 27, X chromosomeprovided by MGI
Primary source
MGI:MGI:1859645
See related
Ensembl:ENSMUSG00000046269 AllianceGenome:MGI:1859645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sfc11; Usp27
Summary
Enables Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Involved in positive regulation of apoptotic process; protein deubiquitination; and protein stabilization. Predicted to be located in cytoplasm and nucleus. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 105. Orthologous to human USP27X (ubiquitin specific peptidase 27 X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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See Usp27x in Genome Data Viewer
Location:
X A1.1; X 3.31 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7238830..7242069, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7372591..7375830, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 5 Neighboring gene microRNA 188 Neighboring gene microRNA 532 Neighboring gene STARR-seq mESC enhancer starr_46661 Neighboring gene predicted gene 14379 Neighboring gene RIKEN cDNA 2010204K13 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I. Tao X, et al. PLoS Pathog, 2020 Feb. PMID 32027733, Free PMC Article
  2. The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. Weber A, et al. EMBO Rep, 2016 May. PMID 27013495, Free PMC Article
  3. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 27
Names
X-linked ubiquitin carboxyl-terminal hydrolase 27
X-linked ubiquitin thioesterase 27
deubiquitinating enzyme 27
ubiquitin specific protease 27, X chromosome
ubiquitin thioesterase 27
ubiquitin thiolesterase 27
ubiquitin-specific-processing protease 27
NP_062334.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019461.4 → NP_062334.2  ubiquitin carboxyl-terminal hydrolase 27

    See identical proteins and their annotated locations for NP_062334.2

    Status: VALIDATED

    Source sequence(s)
    AL663104
    Consensus CDS
    CCDS52983.1
    UniProtKB/Swiss-Prot
    B1ATV2, Q8BSW2, Q8CEG8, Q9JIG5
    Related
    ENSMUSP00000111409.2, ENSMUST00000115744.2
    Conserved Domains (2) summary
    cd02660
    Location:78 → 419
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:77 → 418
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7238830..7242069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CEG8.2 GenPept UniProtKB/Swiss-Prot:Q8CEG8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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