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Magix MAGI family member, X-linked [ Mus musculus (house mouse) ]

Gene ID: 54634, updated on 5-Mar-2024

Summary

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Official Symbol
Magixprovided by MGI
Official Full Name
MAGI family member, X-linkedprovided by MGI
Primary source
MGI:MGI:1859644
See related
Ensembl:ENSMUSG00000031147 AllianceGenome:MGI:1859644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdzx; Sfc18
Summary
Orthologous to human MAGIX (MAGI family member, X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 8.4), liver adult (RPKM 6.5) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 3.46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7539405..7547490, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7673166..7681251, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene synaptophysin Neighboring gene predicted gene 14703 Neighboring gene prickle planar cell polarity protein 3 Neighboring gene proteolipid protein 2 Neighboring gene peptidylprolyl isomerase A pseudogene x_14.1 Neighboring gene G patch domain and KOW motifs

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, et al. Nat Genet, 2001 Jan. PMID 11138001
  2. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, et al. Genomics, 2000 May 1. PMID 10857745
  3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC117659

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
PDZ domain-containing protein MAGIX
Names
PDZ domain containing X chromosome

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018832.2 → NP_061302.2  PDZ domain-containing protein MAGIX

    See identical proteins and their annotated locations for NP_061302.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AK158091, BC099459
    Consensus CDS
    CCDS29968.1
    UniProtKB/Swiss-Prot
    Q4KL35, Q9JIG3
    UniProtKB/TrEMBL
    Q3TZ57
    Related
    ENSMUSP00000111359.4, ENSMUST00000115695.4
    Conserved Domains (1) summary
    smart00228
    Location:126 → 211
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

RNA

  1. NR_037581.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon at its 5' end which results in the loss of a translation initiation site, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to inhibit the translation of the longest in-frame ORF, compared to variant 1, and the latter ORF is significantly truncated.
    Source sequence(s)
    AK077898, AK158091
    Related
    ENSMUST00000130287.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7539405..7547490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KL35.1 GenPept UniProtKB/Swiss-Prot:Q4KL35

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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