U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prrg1 proline rich Gla (G-carboxyglutamic acid) 1 [ Mus musculus (house mouse) ]

Gene ID: 546336, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Prrg1provided by MGI
Official Full Name
proline rich Gla (G-carboxyglutamic acid) 1provided by MGI
Primary source
MGI:MGI:1917364
See related
Ensembl:ENSMUSG00000047996 AllianceGenome:MGI:1917364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010007L08Rik
Summary
Predicted to be active in plasma membrane. Orthologous to human PRRG1 (proline rich and Gla domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 6.0), limb E14.5 (RPKM 2.8) and 18 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X B; X 38.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (77493216..77627539, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (78449610..78583914, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47425 Neighboring gene suppressor of zeste 12 homolog pseudogene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47426 Neighboring gene histone H3.3-like Neighboring gene ring finger protein 41 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane gamma-carboxyglutamic acid protein 1
Names
ortholog of proline rich Gla (G-carboxyglutamic acid) 1 PRRG1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164275.2 → NP_001157747.1  transmembrane gamma-carboxyglutamic acid protein 1

    See identical proteins and their annotated locations for NP_001157747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK135895, AL672300, BX284111, CF915689, CJ052035, CX242928
    Consensus CDS
    CCDS53121.1
    UniProtKB/TrEMBL
    A2BFE8
    Related
    ENSMUSP00000136713.2, ENSMUST00000177904.8
    Conserved Domains (2) summary
    smart00069
    Location:2 → 65
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    pfam15471
    Location:128 → 206
    TMEM171; Transmembrane protein family 171

  2. NM_001289683.1 → NP_001276612.1  transmembrane gamma-carboxyglutamic acid protein 1

    See identical proteins and their annotated locations for NP_001276612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK135895, AL672300, BX284111, CF915689, CX242928
    Consensus CDS
    CCDS53121.1
    UniProtKB/TrEMBL
    A2BFE8
    Related
    ENSMUSP00000109659.2, ENSMUST00000114025.8
    Conserved Domains (2) summary
    smart00069
    Location:2 → 65
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    pfam15471
    Location:128 → 206
    TMEM171; Transmembrane protein family 171

  3. NM_027322.2 → NP_081598.1  transmembrane gamma-carboxyglutamic acid protein 1

    See identical proteins and their annotated locations for NP_081598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK135895, AL672300, BX284111, CF915689, CJ052035, CX242928
    Consensus CDS
    CCDS53121.1
    UniProtKB/TrEMBL
    A2BFE8
    Related
    ENSMUSP00000109658.3, ENSMUST00000114024.9
    Conserved Domains (2) summary
    smart00069
    Location:2 → 65
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    pfam15471
    Location:128 → 206
    TMEM171; Transmembrane protein family 171

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    77493216..77627539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162025.1 → XP_036017918.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

    Conserved Domains (1) summary
    smart00069
    Location:24 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  2. XM_006528143.4 → XP_006528206.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006528206.1

    Conserved Domains (1) summary
    smart00069
    Location:24 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  3. XM_036162022.1 → XP_036017915.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X1

    Conserved Domains (1) summary
    smart00069
    Location:76 → 139
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  4. XM_011247638.3 → XP_011245940.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X6

    See identical proteins and their annotated locations for XP_011245940.1

    UniProtKB/TrEMBL
    A2BFE8
    Conserved Domains (2) summary
    smart00069
    Location:2 → 65
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    pfam15471
    Location:128 → 206
    TMEM171; Transmembrane protein family 171

  5. XM_011247634.3 → XP_011245936.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011245936.1

    Conserved Domains (1) summary
    smart00069
    Location:24 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  6. XM_006528144.4 → XP_006528207.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006528207.1

    Conserved Domains (1) summary
    smart00069
    Location:24 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  7. XM_011247633.4 → XP_011245935.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011245935.1

    Conserved Domains (1) summary
    smart00069
    Location:24 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  8. XM_011247637.3 → XP_011245939.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X6

    See identical proteins and their annotated locations for XP_011245939.1

    UniProtKB/TrEMBL
    A2BFE8
    Conserved Domains (2) summary
    smart00069
    Location:2 → 65
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    pfam15471
    Location:128 → 206
    TMEM171; Transmembrane protein family 171

  9. XM_011247632.3 → XP_011245934.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011245934.1

    Conserved Domains (1) summary
    smart00069
    Location:24 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  10. XM_017318551.3 → XP_017174040.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X6

    UniProtKB/TrEMBL
    A2BFE8
    Conserved Domains (2) summary
    smart00069
    Location:2 → 65
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    pfam15471
    Location:128 → 206
    TMEM171; Transmembrane protein family 171

  11. XM_006528142.5 → XP_006528205.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006528205.1

    Conserved Domains (1) summary
    smart00069
    Location:24 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  12. XM_030251387.2 → XP_030107247.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X6

    UniProtKB/TrEMBL
    A2BFE8
    Conserved Domains (2) summary
    smart00069
    Location:2 → 65
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    pfam15471
    Location:128 → 206
    TMEM171; Transmembrane protein family 171

  13. XM_011247635.2 → XP_011245937.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011245937.1

    Conserved Domains (1) summary
    smart00069
    Location:24 → 87
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  14. XM_036162024.1 → XP_036017917.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X4

    Conserved Domains (1) summary
    smart00069
    Location:39 → 102
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  15. XM_011247631.3 → XP_011245933.2  transmembrane gamma-carboxyglutamic acid protein 1 isoform X3

    Conserved Domains (2) summary
    smart00069
    Location:54 → 117
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    pfam15471
    Location:180 → 258
    TMEM171; Transmembrane protein family 171

  16. XM_036162023.1 → XP_036017916.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X2

    Conserved Domains (1) summary
    smart00069
    Location:41 → 104
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

  17. XM_036162026.1 → XP_036017919.1  transmembrane gamma-carboxyglutamic acid protein 1 isoform X7

    Conserved Domains (1) summary
    smart00069
    Location:54 → 109
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous