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Abhd2 abhydrolase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 54608, updated on 18-Apr-2024

Summary

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Official Symbol
Abhd2provided by MGI
Official Full Name
abhydrolase domain containing 2provided by MGI
Primary source
MGI:MGI:1914344
See related
Ensembl:ENSMUSG00000039202 AllianceGenome:MGI:1914344
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LABH2; Labh-2; 2210009N18Rik
Summary
Predicted to enable carboxylic ester hydrolase activity; hormone binding activity; and steroid hormone receptor activity. Involved in acrosome reaction. Acts upstream of or within negative regulation of cell migration and response to wounding. Located in acrosomal vesicle. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human ABHD2 (abhydrolase domain containing 2, acylglycerol lipase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 82.7), adrenal adult (RPKM 56.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 44.96 cM; 7 D2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (78923002..79015257)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79273266..79361601)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39040 Neighboring gene STARR-seq mESC enhancer starr_19267 Neighboring gene STARR-positive B cell enhancer ABC_E47 Neighboring gene predicted gene, 31510 Neighboring gene predicted gene, 39041 Neighboring gene predicted gene, 24224 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:86508405-86508675 Neighboring gene STARR-positive B cell enhancer ABC_E9694 Neighboring gene retinaldehyde binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_19276 Neighboring gene predicted gene, 31653 Neighboring gene Fanconi anemia, complementation group I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alpha/Beta Hydrolase Domain-Containing Protein 2 Regulates the Rhythm of Follicular Maturation and Estrous Stages of the Female Reproductive Cycle. Björkgren I, et al. Front Cell Dev Biol, 2021. PMID 34568325, Free PMC Article
  2. Age-related pulmonary emphysema in mice lacking alpha/beta hydrolase domain containing 2 gene. Jin S, et al. Biochem Biophys Res Commun, 2009 Mar 6. PMID 19250629
  3. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Miller MR, et al. Science, 2016 Apr 29. PMID 26989199, Free PMC Article
  4. Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene. Miyata K, et al. Biochem Biophys Res Commun, 2005 Apr 1. PMID 15721306
  5. Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs. Edgar AJ, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922611

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-beta.
    Title: Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-β.
  2. ABHD2 deficiency aggravates ovalbumin-induced airway remodeling through the PI3K/Akt pathway in an animal model of chronic asthma.
    Title: ABHD2 deficiency aggravates ovalbumin-induced airway remodeling through the PI3K/Akt pathway in an animal model of chronic asthma.
  3. Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin.
    Title: Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin.
  4. These findings suggest that derangement in alveolar phospholipid metabolism can induce emphysema, and that Abhd2 plays a critical role in maintaining lung structural integrity.
    Title: Age-related pulmonary emphysema in mice lacking alpha/beta hydrolase domain containing 2 gene.
  5. LABH-2 protein is a member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the testis
    Title: Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107122

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables acylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables hormone-sensitive lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear steroid receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acrosome reaction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in acylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in medium-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to progesterone ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm capacitation ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid hormone mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid hormone mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
is_active_in sperm plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
monoacylglycerol lipase ABHD2
Names
2-arachidonoylglycerol hydrolase
abhydrolase domain-containing protein 2
acetylesterase
alpha/beta hydrolase fold protein
lung alpha/beta hydrolase 2
mmLABH2
triacylglycerol lipase
NP_061281.3
XP_036009150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018811.6 → NP_061281.3  monoacylglycerol lipase ABHD2

    See identical proteins and their annotated locations for NP_061281.3

    Status: PROVISIONAL

    Source sequence(s)
    AC160464
    Consensus CDS
    CCDS21380.1
    UniProtKB/Swiss-Prot
    Q3U5E8, Q5FWC6, Q9D7Y8, Q9QXM0
    Related
    ENSMUSP00000038361.7, ENSMUST00000037315.13
    Conserved Domains (1) summary
    cl21494
    Location:65 → 400
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    78923002..79015257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153257.1 → XP_036009150.1  monoacylglycerol lipase ABHD2 isoform X1

    UniProtKB/Swiss-Prot
    Q3U5E8, Q5FWC6, Q9D7Y8, Q9QXM0
    Conserved Domains (1) summary
    cl21494
    Location:65 → 400
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXM0.1 GenPept UniProtKB/Swiss-Prot:Q9QXM0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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