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Calcrl calcitonin receptor-like [ Mus musculus (house mouse) ]

Gene ID: 54598, updated on 18-Apr-2024

Summary

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Official Symbol
Calcrlprovided by MGI
Official Full Name
calcitonin receptor-likeprovided by MGI
Primary source
MGI:MGI:1926944
See related
Ensembl:ENSMUSG00000059588 AllianceGenome:MGI:1926944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRLR
Summary
Enables calcitonin gene-related peptide receptor activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; heart development; and positive regulation of smooth muscle cell proliferation. Predicted to be located in endoplasmic reticulum; endosome; and lysosome. Predicted to be part of CGRP receptor complex and adrenomedullin receptor complex. Predicted to be active in plasma membrane. Is expressed in dorsal root ganglion and lung epithelium. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CALCRL (calcitonin receptor like receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 53.6), bladder adult (RPKM 7.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 D; 2 49.38 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84160970..84255786, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84330626..84425405, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04994 Neighboring gene predicted gene, 54167 Neighboring gene STARR-positive B cell enhancer mm9_chr2:84263150-84263451 Neighboring gene STARR-positive B cell enhancer ABC_E3384 Neighboring gene STARR-positive B cell enhancer ABC_E5941 Neighboring gene STARR-positive B cell enhancer ABC_E7834 Neighboring gene STARR-positive B cell enhancer ABC_E2040 Neighboring gene tissue factor pathway inhibitor Neighboring gene STARR-positive B cell enhancer ABC_E4474 Neighboring gene STARR-seq mESC enhancer starr_04996 Neighboring gene predicted gene 13710

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of caveolae in regulating calcitonin receptor-like receptor subcellular distribution in vascular smooth muscle cells. Tang JQ, et al. Biochem Cell Biol, 2013 Oct. PMID 24032687
  2. Characteristics of multi-organ lymphangiectasia resulting from temporal deletion of calcitonin receptor-like receptor in adult mice. Hoopes SL, et al. PLoS One, 2012. PMID 23028890, Free PMC Article
  3. Fetal-derived adrenomedullin mediates the innate immune milieu of the placenta. Li M, et al. J Clin Invest, 2013 Jun. PMID 23635772, Free PMC Article
  4. Disturbed flow-induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis. Nakayama A, et al. JCI Insight, 2020 Dec 3. PMID 33268595, Free PMC Article
  5. CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis. Suekane A, et al. Sci Rep, 2019 Jan 23. PMID 30674976, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
    Title: CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis.
  2. lymphatic insufficiency and lymphangiectasia caused by loss of lymphatic Calcrl exacerbates intestinal recovery following mucosal injury and underscores the importance of lymphatic function in promoting recovery from intestinal inflammation
    Title: Lymphatic deletion of calcitonin receptor-like receptor exacerbates intestinal inflammation.
  3. study reveals a Notch-Collagen V-Calcitonin receptor signalling cascade that maintains satellite cells in a quiescent state in a cell-autonomous fashion, and raises the possibility that similar reciprocal mechanisms act in diverse stem cell populations
    Title: Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche.
  4. the cardiovascular response of Ramp1(-/-), Ramp2(+/-), Ramp3(-/-), Ramp1(-/-)/Ramp3(-/-) double-knockout (dKO), and Calcrl(+/-) mice to AM and CGRP were compared to wildtype mice.These results suggest that the hypotensive effect of AM is primarily mediated through the CLR/RAMP1 heterodimer, but that AM signaling via CLR/RAMP2 and CLR/RAMP3 also contributes to some hypotensive action.
    Title: Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice.
  5. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
    Title: Spatial expression of components of a calcitonin receptor-like receptor (CRL) signalling system (CRL, calcitonin gene-related peptide, adrenomedullin, adrenomedullin-2/intermedin) in mouse and human heart valves.
  6. these data indicate that the structural integrity of caveolae plays an important role in regulating subcellular distribution of CLR.
    Title: The role of caveolae in regulating calcitonin receptor-like receptor subcellular distribution in vascular smooth muscle cells.
  7. Calcrl deficiency results in multi-organ lymphangiectasia in adult mice.
    Title: Characteristics of multi-organ lymphangiectasia resulting from temporal deletion of calcitonin receptor-like receptor in adult mice.
  8. Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3, but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR), and RAMP1 and RAMP2.
    Title: Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice.
  9. CTR is not only down regulated by signaling through the CTR but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins
    Title: Expression of the calcitonin receptor, calcitonin receptor-like receptor, and receptor activity modifying proteins during osteoclast differentiation.
  10. loss of calcrl in endothelial cells confirmed an essential role for AM signaling in vascular development.
    Title: Adrenomedullin signaling is necessary for murine lymphatic vascular development.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables adrenomedullin binding ISO
Inferred from Sequence Orthology
more info
  
enables adrenomedullin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adrenomedullin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables calcitonin gene-related peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcitonin gene-related peptide receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables calcitonin gene-related peptide receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables calcitonin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in adrenomedullin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adrenomedullin receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in calcitonin gene-related peptide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to sucrose stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CGRP receptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of adrenomedullin receptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcitonin gene-related peptide type 1 receptor
Names
CGRP type 1 receptor
calcitonin receptor-like receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018782.2 → NP_061252.2  calcitonin gene-related peptide type 1 receptor precursor

    See identical proteins and their annotated locations for NP_061252.2

    Status: VALIDATED

    Source sequence(s)
    AF146525, AF209905, AK137210, CB595628, DY245973
    Consensus CDS
    CCDS16184.1
    UniProtKB/Swiss-Prot
    Q9QXH8, Q9R1W5, Q9WUP2
    UniProtKB/TrEMBL
    A2AR99
    Related
    ENSMUSP00000073875.3, ENSMUST00000074262.9
    Conserved Domains (2) summary
    cd15274
    Location:137 → 410
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:61 → 128
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84160970..84255786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499918.5 → XP_006499981.1  calcitonin gene-related peptide type 1 receptor isoform X1

    See identical proteins and their annotated locations for XP_006499981.1

    UniProtKB/Swiss-Prot
    Q9QXH8, Q9R1W5, Q9WUP2
    UniProtKB/TrEMBL
    A2AR99
    Conserved Domains (2) summary
    cd15274
    Location:137 → 410
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:61 → 128
    HRM; Hormone receptor domain

  2. XM_036162403.1 → XP_036018296.1  calcitonin gene-related peptide type 1 receptor isoform X1

    UniProtKB/Swiss-Prot
    Q9QXH8, Q9R1W5, Q9WUP2
    UniProtKB/TrEMBL
    A2AR99
    Conserved Domains (2) summary
    cd15274
    Location:137 → 410
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:61 → 128
    HRM; Hormone receptor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1W5.2 GenPept UniProtKB/Swiss-Prot:Q9R1W5

Gene LinkOut

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