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Cep170 centrosomal protein 170 [ Mus musculus (house mouse) ]

Gene ID: 545389, updated on 5-Mar-2024

Summary

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Official Symbol
Cep170provided by MGI
Official Full Name
centrosomal protein 170provided by MGI
Primary source
MGI:MGI:1918348
See related
Ensembl:ENSMUSG00000057335 AllianceGenome:MGI:1918348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933426L22Rik; A330004A13Rik
Summary
Located in centriole. Orthologous to human CEP170 (centrosomal protein 170). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 23.9), whole brain E14.5 (RPKM 21.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Cep170 in Genome Data Viewer
Location:
1 H4; 1 82.6 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (176556638..176641545, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (176729072..176813979, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03117 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03118 Neighboring gene STARR-positive B cell enhancer ABC_E3336 Neighboring gene STARR-seq mESC enhancer starr_03119 Neighboring gene STARR-seq mESC enhancer starr_03120 Neighboring gene predicted gene, 26104 Neighboring gene STARR-positive B cell enhancer ABC_E10063 Neighboring gene STARR-positive B cell enhancer ABC_E10064 Neighboring gene microRNA 350 Neighboring gene STARR-positive B cell enhancer ABC_E3337 Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene high mobility group AT-hook 2, pseudogene 1 Neighboring gene predicted gene, 38158 Neighboring gene STARR-positive B cell enhancer ABC_E5862 Neighboring gene predicted gene 15423

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis. Qin Y, et al. Development, 2019 Oct 21. PMID 31533924
  2. Actin-dependent regulation of cilia length by the inverted formin FHDC1. Copeland SJ, et al. Mol Biol Cell, 2018 Jul 1. PMID 29742020, Free PMC Article
  3. The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Guarguaglini G, et al. Mol Biol Cell, 2005 Mar. PMID 15616186, Free PMC Article
  4. Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors. Zhang W, et al. Nat Commun, 2019 Jun 13. PMID 31197141, Free PMC Article
  5. RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain. Valnegri P, et al. Nat Commun, 2017 Nov 2. PMID 29097665, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis
    Title: WDR62 is involved in spindle assembly by interacting with CEP170 in spermatogenesis.
  2. Study in mutant mice and human cerebral organoids showed that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells. WDR62 interacts with and promotes CEP170 localization to the basal body of primary cilium, where CEP170 recruits KIF2A to disassemble cilium.
    Title: Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.
  3. Cep170 interacts with Polo-like kinase 1 in mature centrioles [Cep170]
    Title: The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of centriolar subdistal appendage ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 170 kDa
Names
KARP-1-binding protein
centrosomal protein 170kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099637.2 → NP_001093107.2  centrosomal protein of 170 kDa isoform 1

    See identical proteins and their annotated locations for NP_001093107.2

    Status: VALIDATED

    Source sequence(s)
    AC113311, AC144905
    Consensus CDS
    CCDS48461.1
    UniProtKB/TrEMBL
    H7BX26
    Related
    ENSMUSP00000059562.7, ENSMUST00000057037.13
    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:802 → 1496
    CEP170_C; CEP170 C-terminus

  2. NM_001368872.1 → NP_001355801.1  centrosomal protein of 170 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113311, AC144905
    Conserved Domains (2) summary
    pfam15308
    Location:655 → 1331
    CEP170_C; CEP170 C-terminus
    pfam00498
    Location:23 → 89
    FHA; FHA domain

  3. NM_001368873.1 → NP_001355802.1  centrosomal protein of 170 kDa isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113311
    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:704 → 1408
    CEP170_C; CEP170 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    176556638..176641545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152447.1 → XP_036008340.1  centrosomal protein of 170 kDa isoform X15

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:667 → 1309
    CEP170_C; CEP170 C-terminus

  2. XM_036152446.1 → XP_036008339.1  centrosomal protein of 170 kDa isoform X14

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:667 → 1319
    CEP170_C; CEP170 C-terminus

  3. XM_017321736.3 → XP_017177225.1  centrosomal protein of 170 kDa isoform X13

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:654 → 1348
    CEP170_C; CEP170 C-terminus

  4. XM_006496947.4 → XP_006497010.1  centrosomal protein of 170 kDa isoform X11

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:704 → 1372
    CEP170_C; CEP170 C-terminus

  5. XM_006496945.5 → XP_006497008.1  centrosomal protein of 170 kDa isoform X10

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:704 → 1398
    CEP170_C; CEP170 C-terminus

  6. XM_036152443.1 → XP_036008336.1  centrosomal protein of 170 kDa isoform X7

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:765 → 1443
    CEP170_C; CEP170 C-terminus

  7. XM_030255572.1 → XP_030111432.1  centrosomal protein of 170 kDa isoform X8

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:802 → 1443
    CEP170_C; CEP170 C-terminus

  8. XM_030255571.1 → XP_030111431.1  centrosomal protein of 170 kDa isoform X5

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:802 → 1460
    CEP170_C; CEP170 C-terminus

  9. XM_030255570.1 → XP_030111430.1  centrosomal protein of 170 kDa isoform X4

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:802 → 1470
    CEP170_C; CEP170 C-terminus

  10. XM_030255569.1 → XP_030111429.1  centrosomal protein of 170 kDa isoform X3

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:802 → 1479
    CEP170_C; CEP170 C-terminus

  11. XM_006496939.5 → XP_006497002.1  centrosomal protein of 170 kDa isoform X2

    See identical proteins and their annotated locations for XP_006497002.1

    UniProtKB/TrEMBL
    H7BX26
    Related
    ENSMUSP00000141769.2, ENSMUST00000195717.6
    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:802 → 1496
    CEP170_C; CEP170 C-terminus

  12. XM_006496937.4 → XP_006497000.1  centrosomal protein of 170 kDa isoform X1

    See identical proteins and their annotated locations for XP_006497000.1

    UniProtKB/Swiss-Prot
    Q6A065, Q7TQD9, Q8BJW2, Q9D3Z0
    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:802 → 1506
    CEP170_C; CEP170 C-terminus

  13. XM_006496940.5 → XP_006497003.1  centrosomal protein of 170 kDa isoform X2

    See identical proteins and their annotated locations for XP_006497003.1

    UniProtKB/TrEMBL
    H7BX26
    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:802 → 1496
    CEP170_C; CEP170 C-terminus

  14. XM_006496948.5 → XP_006497011.1  centrosomal protein of 170 kDa isoform X12

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:654 → 1358
    CEP170_C; CEP170 C-terminus

  15. XM_006496944.5 → XP_006497007.1  centrosomal protein of 170 kDa isoform X9

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:704 → 1408
    CEP170_C; CEP170 C-terminus

  16. XM_006496943.5 → XP_006497006.1  centrosomal protein of 170 kDa isoform X6

    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:752 → 1456
    CEP170_C; CEP170 C-terminus

  17. XM_030255566.2 → XP_030111426.1  centrosomal protein of 170 kDa isoform X1

    UniProtKB/Swiss-Prot
    Q6A065, Q7TQD9, Q8BJW2, Q9D3Z0
    Related
    ENSMUSP00000141793.2, ENSMUST00000194727.6
    Conserved Domains (2) summary
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:802 → 1506
    CEP170_C; CEP170 C-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024722.1: Suppressed sequence

    Description
    NM_001024722.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6A065.2 GenPept UniProtKB/Swiss-Prot:Q6A065

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