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Baiap3 BAI1-associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 545192, updated on 11-Apr-2024

Summary

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Official Symbol
Baiap3provided by MGI
Official Full Name
BAI1-associated protein 3provided by MGI
Primary source
MGI:MGI:2685783
See related
Ensembl:ENSMUSG00000047507 AllianceGenome:MGI:2685783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bap3; Gm937
Summary
Predicted to enable calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in regulation of GABAergic synaptic transmission and regulation of behavior. Located in GABA-ergic synapse. Is expressed in brain. Orthologous to human BAIAP3 (BAI1 associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 8.6), CNS E18 (RPKM 8.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.53 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25461633..25475255, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25242659..25256364, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52286 Neighboring gene unkempt family like zinc finger Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene microRNA 3547 Neighboring gene ubiquitin-conjugating enzyme E2I Neighboring gene STARR-positive B cell enhancer ABC_E8659 Neighboring gene predicted gene, 17801 Neighboring gene serine protease 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. Wojcik SM, et al. Mol Med, 2013 Jul 24. PMID 23698091, Free PMC Article
  2. Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. Man KN, et al. Elife, 2015 Nov 17. PMID 26575293, Free PMC Article
  3. Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. Vogl C, et al. J Cell Sci, 2015 Feb 15. PMID 25609709
  4. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Dillman AA, et al. Nat Neurosci, 2013 Apr. PMID 23416452, Free PMC Article
  5. Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. Scavuzzo MA, et al. Nat Commun, 2018 Aug 22. PMID 30135482, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Baiap3 is gender specifically associated with anxiety and benzodiazepine use disorder.
    Title: Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in dense core granule maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dense core granule exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dense core granule exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in GABA-ergic synapse IC
Inferred by Curator
more info
 PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in secretory vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BAI1-associated protein 3
Names
brain-specific angiogenesis inhibitor I-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163270.2 → NP_001156742.1  BAI1-associated protein 3

    See identical proteins and their annotated locations for NP_001156742.1

    Status: VALIDATED

    Source sequence(s)
    AC122454
    Consensus CDS
    CCDS50033.1
    UniProtKB/Swiss-Prot
    E9QQ76, Q6RUT4, Q80TT2, S4R1E7
    UniProtKB/TrEMBL
    B2RY68
    Related
    ENSMUSP00000138188.2, ENSMUST00000182056.8
    Conserved Domains (3) summary
    cd04009
    Location:973 → 1102
    C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
    cd08676
    Location:131 → 330
    C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
    pfam10540
    Location:852 → 954
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

  2. NM_001408206.1 → NP_001395135.1  BAI1-associated protein 3

    Status: VALIDATED

    Source sequence(s)
    AC122454
    UniProtKB/Swiss-Prot
    E9QQ76, Q6RUT4, Q80TT2, S4R1E7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25461633..25475255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524643.5 → XP_006524706.1  BAI1-associated protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006524706.1

    UniProtKB/Swiss-Prot
    E9QQ76, Q6RUT4, Q80TT2, S4R1E7
    UniProtKB/TrEMBL
    B2RY68
    Conserved Domains (3) summary
    cd04009
    Location:973 → 1102
    C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
    cd08676
    Location:131 → 330
    C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
    pfam10540
    Location:852 → 954
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TT2.4 GenPept UniProtKB/Swiss-Prot:Q80TT2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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