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Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 54519, updated on 5-Mar-2024

Summary

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Official Symbol
Apbb1ipprovided by MGI
Official Full Name
amyloid beta precursor protein binding family B member 1 interacting proteinprovided by MGI
Primary source
MGI:MGI:1861354
See related
Ensembl:ENSMUSG00000026786 AllianceGenome:MGI:1861354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prp48; 9930118P07Rik
Summary
Acts upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Located in cytosol and plasma membrane. Part of T cell receptor complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and molar. Orthologous to human APBB1IP (amyloid beta precursor protein binding family B member 1 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 9.0), spleen adult (RPKM 6.8) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 15.15 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (22645983..22765671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (22755971..22875653)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glutamic acid decarboxylase 2 Neighboring gene microRNA 3967 Neighboring gene STARR-seq mESC enhancer starr_03915 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4417 Neighboring gene STARR-seq mESC enhancer starr_03917 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:22661206-22661359 Neighboring gene STARR-positive B cell enhancer ABC_E7796 Neighboring gene STARR-seq mESC enhancer starr_03918 Neighboring gene STARR-seq mESC enhancer starr_03919 Neighboring gene STARR-seq mESC enhancer starr_03920 Neighboring gene STARR-seq mESC enhancer starr_03922 Neighboring gene predicted gene, 52503 Neighboring gene prenyl (solanesyl) diphosphate synthase, subunit 1 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene abl interactor 1 Neighboring gene STARR-seq mESC enhancer starr_03923 Neighboring gene predicted gene, 52502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes. Lagarrigue F, et al. J Immunol, 2017 May 1. PMID 28348273, Free PMC Article
  2. Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice. Stritt S, et al. Blood, 2015 Jan 8. PMID 25336629, Free PMC Article
  3. Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration. Zhang H, et al. Structure, 2016 May 3. PMID 27150043, Free PMC Article
  4. Structural and mechanistic insights into the recruitment of talin by RIAM in integrin signaling. Chang YC, et al. Structure, 2014 Dec 2. PMID 25465129, Free PMC Article
  5. The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism. Zhang H, et al. J Mol Cell Biol, 2014 Apr. PMID 24287201, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data identify the requirement of RIAM for formation of immunological synapses and in resulting T cell functions in autoimmunity.
    Title: Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes.
  2. we show that leukocyte integrin activation critically depends on RIAM both in vitro and in vivo
    Title: Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice.
  3. These in vivo results confirm a role for RIAM in the regulation of some, but not all, leukocyte integrins and suggest that RIAM-regulated integrin activation is required for trafficking of lymphocytes
    Title: Rap1 and its effector RIAM are required for lymphocyte trafficking.
  4. Conformational activation of talin by PREL-1 triggers integrin-mediated cell adhesion.
    Title: Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.
  5. crystal structure of an active, GTP-bound GTPase domain of Rap1 in complex with the Ras association (RA)-pleckstrin homology (PH) structural module of RIAM at 1.65 A, is reported.
    Title: The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism.
  6. generated RIAM-null mice and found that they are viable, fertile, and apparently healthy
    Title: Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice.
  7. As talin engages F-actin, force exerted on the R2R3 helical bundles disrupts RIAM binding and exposes the vinculin binding sites, which recruit vinculin to stabilize the complex.
    Title: RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
  8. Data demonstrate a novel mechanism by which alphavbeta3 integrin acts to locally suppress beta1 integrin activation and regulate VASP and RIAM to control cell adhesion and migration.
    Title: Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of T cell receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Names
APBB1-interacting protein 1
PREL-1
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
proline-rich EVH1 ligand 1
proline-rich protein 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019456.2 → NP_062329.2  amyloid beta A4 precursor protein-binding family B member 1-interacting protein

    See identical proteins and their annotated locations for NP_062329.2

    Status: VALIDATED

    Source sequence(s)
    AK021331, AK041552, AK089987, BB638237, CT030013
    Consensus CDS
    CCDS38056.1
    UniProtKB/Swiss-Prot
    O35329, Q8BRU0, Q8R5A3, Q99KV8
    UniProtKB/TrEMBL
    B1AYC9
    Related
    ENSMUSP00000014290.9, ENSMUST00000014290.15
    Conserved Domains (2) summary
    cd01259
    Location:310 → 431
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16137
    Location:186 → 267
    RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    22645983..22765671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498186.4 → XP_006498249.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006498249.1

    UniProtKB/Swiss-Prot
    O35329, Q8BRU0, Q8R5A3, Q99KV8
    UniProtKB/TrEMBL
    B1AYC9
    Conserved Domains (2) summary
    cd01259
    Location:310 → 431
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16137
    Location:186 → 267
    RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)

  2. XM_006498187.2 → XP_006498250.1  amyloid beta A4 precursor protein-binding family B member 1-interacting protein isoform X2

    Conserved Domains (2) summary
    cd01259
    Location:243 → 364
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16137
    Location:119 → 200
    RA_MRL_RIAM; Ras-associating (RA) domain found in Rap1-GTP-interacting adapter molecule (RIAM)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5A3.2 GenPept UniProtKB/Swiss-Prot:Q8R5A3

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