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Bdp1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB [ Mus musculus (house mouse) ]

Gene ID: 544971, updated on 5-Mar-2024

Summary

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Official Symbol
Bdp1provided by MGI
Official Full Name
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIBprovided by MGI
Primary source
MGI:MGI:1347077
See related
Ensembl:ENSMUSG00000049658 AllianceGenome:MGI:1347077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TFC5; Tfnr; TAF3B1; TFIIIB90; TFIIIB150; mKIAA1241; B130055N23Rik; G630013P12Rik
Summary
Predicted to enable TFIIIC-class transcription factor complex binding activity. Predicted to be involved in RNA polymerase III preinitiation complex assembly. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIB complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 112. Orthologous to human BDP1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.1), liver E14 (RPKM 2.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D1; 13 52.92 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100154502..100244524, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100017994..100104090, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41039 Neighboring gene methylcrotonoyl-Coenzyme A carboxylase 2 (beta) Neighboring gene STARR-positive B cell enhancer ABC_E1885 Neighboring gene STARR-positive B cell enhancer ABC_E2419 Neighboring gene STARR-positive B cell enhancer ABC_E3095 Neighboring gene small EDRK-rich factor 1 Neighboring gene survival motor neuron 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss. Girotto G, et al. PLoS One, 2013. PMID 24312468, Free PMC Article
  2. The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1. Kelter AR, et al. Genomics, 2000 Dec 15. PMID 11161782
  3. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Diez E, et al. Nat Genet, 2003 Jan. PMID 12483212
  4. Comparative sequence analysis of the mouse and human Lgn1/SMA interval. Endrizzi M, et al. Genomics, 1999 Sep 1. PMID 10486205
  5. Genomic sequence analysis of the mouse Naip gene array. Endrizzi MG, et al. Genome Res, 2000 Aug. PMID 10958627, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.
    Title: Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1241

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TFIIIC-class transcription factor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase III preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription factor TFIIIB complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor TFIIIB component B'' homolog
Names
transcription factor IIIB 150
transcription factor-like nuclear regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081061.1 → NP_001074530.1  transcription factor TFIIIB component B'' homolog

    See identical proteins and their annotated locations for NP_001074530.1

    Status: VALIDATED

    Source sequence(s)
    CT025569, CT030167
    Consensus CDS
    CCDS49343.1
    UniProtKB/Swiss-Prot
    Q571C7, Q8BTI4, Q8K0U7
    Related
    ENSMUSP00000038321.6, ENSMUST00000038104.12
    Conserved Domains (2) summary
    COG5118
    Location:93 → 416
    BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
    pfam15963
    Location:299 → 382
    Myb_DNA-bind_7; Myb DNA-binding like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100154502..100244524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158096.1 → XP_036013989.1  transcription factor TFIIIB component B'' homolog isoform X6

  2. XM_017315546.2 → XP_017171035.1  transcription factor TFIIIB component B'' homolog isoform X1

    Conserved Domains (2) summary
    COG5118
    Location:93 → 415
    BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
    pfam15963
    Location:298 → 381
    Myb_DNA-bind_7; Myb DNA-binding like

  3. XM_036158094.1 → XP_036013987.1  transcription factor TFIIIB component B'' homolog isoform X4

    Conserved Domains (2) summary
    COG5118
    Location:93 → 426
    BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
    pfam15963
    Location:295 → 379
    Myb_DNA-bind_7; Myb DNA-binding like

  4. XM_036158093.1 → XP_036013986.1  transcription factor TFIIIB component B'' homolog isoform X3

    Conserved Domains (2) summary
    COG5118
    Location:93 → 426
    BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
    pfam15963
    Location:295 → 379
    Myb_DNA-bind_7; Myb DNA-binding like

  5. XM_017315545.3 → XP_017171034.1  transcription factor TFIIIB component B'' homolog isoform X2

    Conserved Domains (2) summary
    COG5118
    Location:93 → 416
    BDP1; Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]
    pfam15963
    Location:299 → 382
    Myb_DNA-bind_7; Myb DNA-binding like

  6. XM_036158097.1 → XP_036013990.1  transcription factor TFIIIB component B'' homolog isoform X6

  7. XM_036158095.1 → XP_036013988.1  transcription factor TFIIIB component B'' homolog isoform X5

    Conserved Domains (1) summary
    pfam15963
    Location:40 → 124
    Myb_DNA-bind_7; Myb DNA-binding like

RNA

  1. XR_382739.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q571C7.2 GenPept UniProtKB/Swiss-Prot:Q571C7

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