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Fmn2 formin 2 [ Mus musculus (house mouse) ]

Gene ID: 54418, updated on 11-Apr-2024

Summary

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Official Symbol
Fmn2provided by MGI
Official Full Name
formin 2provided by MGI
Primary source
MGI:MGI:1859252
See related
Ensembl:ENSMUSG00000028354 AllianceGenome:MGI:1859252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin binding activity. Involved in several processes, including cytoskeleton organization; meiotic nuclear division; and oogenesis. Acts upstream of or within actin filament bundle assembly and meiotic chromosome movement towards spindle pole. Located in several cellular components, including endoplasmic reticulum membrane; microvillus; and spindle. Is expressed in several structures, including brain; ganglia; neural ectoderm; otocyst; and testis. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human FMN2 (formin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 7.4), cortex adult (RPKM 7.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 81.04 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (174324079..174650295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (174501752..174822729)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:176399948-176400249 Neighboring gene STARR-seq mESC enhancer starr_03089 Neighboring gene STARR-seq mESC enhancer starr_03090 Neighboring gene STARR-seq mESC enhancer starr_03091 Neighboring gene STARR-seq mESC enhancer starr_03092 Neighboring gene olfactory receptor family 6 subfamily P member 1 Neighboring gene olfactory receptor family 6 subfamily Y member 1 Neighboring gene STARR-seq mESC enhancer starr_03094 Neighboring gene lines homolog 2 pseudogene Neighboring gene predicted gene, 51689 Neighboring gene STARR-seq mESC enhancer starr_03095 Neighboring gene gremlin 2, DAN family BMP antagonist Neighboring gene STARR-seq mESC enhancer starr_03096 Neighboring gene STARR-seq mESC enhancer starr_03097 Neighboring gene STARR-seq mESC enhancer starr_03098 Neighboring gene STARR-seq mESC enhancer starr_03100 Neighboring gene regulator of G protein signaling 7 Neighboring gene predicted gene, 53483

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Artificially decreasing cortical tension generates aneuploidy in mouse oocytes. Bennabi I, et al. Nat Commun, 2020 Apr 3. PMID 32245998, Free PMC Article
  2. Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes. Duan X, et al. Nat Commun, 2020 Jan 14. PMID 31937754, Free PMC Article
  3. Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes. Almonacid M, et al. Dev Cell, 2019 Oct 21. PMID 31607652
  4. Actin protects mammalian eggs against chromosome segregation errors. Mogessie B, et al. Science, 2017 Aug 25. PMID 28839045
  5. Symmetry breaking in mouse oocytes requires transient F-actin meshwork destabilization. Azoury J, et al. Development, 2011 Jul. PMID 21653611

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair.
    Title: Genome-wide study reveals novel roles for formin-2 in axon regeneration as a microtubule dynamics regulator and therapeutic target for nerve repair.
  2. Two mechanisms drive pronuclear migration in mouse zygotes.
    Title: Two mechanisms drive pronuclear migration in mouse zygotes.
  3. Formin 2 Regulates Lysosomal Degradation of Wnt-Associated beta-Catenin in Neural Progenitors.
    Title: Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.
  4. FlnA and Fmn2 are likely essential to cell proliferation, differentiation and cell death in a variety of tissues and organs, further reiterating the importance of vesicle trafficking in regulation of development
    Title: FilaminA and Formin2 regulate skeletal, muscular, and intestinal formation through mesenchymal progenitor proliferation.
  5. Fmn2 mutant mice develop accelerated age-associated memory decline that is further increased in the presence of additional risk factors and is mechanistically linked to a loss of transcriptional homeostasis.
    Title: Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.
  6. Fmn2 as a mediator of actin bundle integrity, enabling efficient force transmission to the adhesion sites.
    Title: Formin 2 regulates the stabilization of filopodial tip adhesions in growth cones and affects neuronal outgrowth and pathfinding in vivo.
  7. Data suggest formin homology domain (FH2) of Fmn2 binds actin at filament barbed end as weak capper and plays a role in displacing WASP homology domain 2 (WH2) domains of Spire-1 from actin; competitive binding of Fmn2 vs Spire-1 aids actin assembly.
    Title: Role of the C-terminal Extension of Formin 2 in Its Activation by Spire Protein and Processive Assembly of Actin Filaments.
  8. Spire recruits Fmn2 and facilitates its association with actin filaments barbed ends.
    Title: Spire and Formin 2 synergize and antagonize in regulating actin assembly in meiosis by a ping-pong mechanism.
  9. Results suggest that the regulation of microtubule acetylation is likely a general formin activity.
    Title: The ability to induce microtubule acetylation is a general feature of formin proteins.
  10. analysis of the molecular basis of the Spir1/formin-2 interaction
    Title: Molecular basis of actin nucleation factor cooperativity: crystal structure of the Spir-1 kinase non-catalytic C-lobe domain (KIND)•formin-2 formin SPIR interaction motif (FSI) complex.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of meiotic spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in formin-nucleated actin cable assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in formin-nucleated actin cable assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in homologous chromosome movement towards spindle pole in meiosis I anaphase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic chromosome movement towards spindle pole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polar body extrusion after meiotic divisions IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microvillus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
formin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019445.2 → NP_062318.2  formin-2

    See identical proteins and their annotated locations for NP_062318.2

    Status: VALIDATED

    Source sequence(s)
    BC094606, BM228488, BP758042
    Consensus CDS
    CCDS48459.1
    UniProtKB/Swiss-Prot
    Q505D3, Q9JL04
    Related
    ENSMUSP00000030039.8, ENSMUST00000030039.13
    Conserved Domains (1) summary
    pfam02181
    Location:1139 → 1529
    FH2; Formin Homology 2 Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    174324079..174650295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152433.1 → XP_036008326.1  formin-2 isoform X1

    Conserved Domains (2) summary
    PTZ00449
    Location:213 → 450
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cl19758
    Location:1139 → 1216
    FH2; Formin Homology 2 Domain

  2. XM_030255545.1 → XP_030111405.1  formin-2 isoform X2

    Conserved Domains (1) summary
    pfam02181
    Location:634 → 1024
    FH2; Formin Homology 2 Domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL04.2 GenPept UniProtKB/Swiss-Prot:Q9JL04

Gene LinkOut

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