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Ppt2 palmitoyl-protein thioesterase 2 [ Mus musculus (house mouse) ]

Gene ID: 54397, updated on 11-Apr-2024

Summary

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Official Symbol
Ppt2provided by MGI
Official Full Name
palmitoyl-protein thioesterase 2provided by MGI
Primary source
MGI:MGI:1860075
See related
Ensembl:ENSMUSG00000015474 AllianceGenome:MGI:1860075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610007M19Rik
Summary
Predicted to enable palmitoyl hydrolase activity and thiolester hydrolase activity. Predicted to be active in lysosome. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Used to study neuronal ceroid lipofuscinosis. Orthologous to human PPT2 (palmitoyl-protein thioesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 28.5), thymus adult (RPKM 24.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.19 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34835636..34856993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34616662..34638022, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E45 Neighboring gene STARR-positive B cell enhancer ABC_E11640 Neighboring gene ring finger protein 5 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene EGF-like domain 8 Neighboring gene RIKEN cDNA 2610029K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34767227-34767451 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34768061-34768244 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E770 Neighboring gene STARR-positive B cell enhancer ABC_E4212 Neighboring gene FK506 binding protein-like Neighboring gene activating transcription factor 6 beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features. Gupta P, et al. Proc Natl Acad Sci U S A, 2003 Oct 14. PMID 14528005, Free PMC Article
  2. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Gupta P, et al. Proc Natl Acad Sci U S A, 2001 Nov 20. PMID 11717424, Free PMC Article
  3. Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease. Cho SK, et al. Glycobiology, 2005 Jun. PMID 15647513
  4. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. Xie T, et al. Genome Res, 2003 Dec. PMID 14656967, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables thiolester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysosomal thioesterase PPT2
NP_001289322.1
NP_001289323.1
NP_001289324.1
NP_001289325.1
NP_062314.1
XP_006524697.1
XP_006524701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302393.1 → NP_001289322.1  lysosomal thioesterase PPT2 precursor

    See identical proteins and their annotated locations for NP_001289322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All the variants encode the same protein.
    Source sequence(s)
    BY317801, CO044617, CT009767, CX201936, CX565661
    Consensus CDS
    CCDS28652.1
    UniProtKB/Swiss-Prot
    O35448, Q80WP5
    UniProtKB/TrEMBL
    F6SPQ1
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 276
    Palm_thioest; Palmitoyl protein thioesterase

  2. NM_001302394.1 → NP_001289323.1  lysosomal thioesterase PPT2 precursor

    See identical proteins and their annotated locations for NP_001289323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All the variants encode the same protein.
    Source sequence(s)
    CJ076607, CO044617, CT009767, CX201936, CX565661
    Consensus CDS
    CCDS28652.1
    UniProtKB/Swiss-Prot
    O35448, Q80WP5
    UniProtKB/TrEMBL
    F6SPQ1
    Related
    ENSMUSP00000132006.3, ENSMUST00000166040.9
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 276
    Palm_thioest; Palmitoyl protein thioesterase

  3. NM_001302395.1 → NP_001289324.1  lysosomal thioesterase PPT2 precursor

    See identical proteins and their annotated locations for NP_001289324.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All the variants encode the same protein.
    Source sequence(s)
    AK002301, CO044617, CT009767, CX201936, CX565661
    Consensus CDS
    CCDS28652.1
    UniProtKB/Swiss-Prot
    O35448, Q80WP5
    UniProtKB/TrEMBL
    F6SPQ1
    Related
    ENSMUSP00000068071.9, ENSMUST00000064953.15
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 276
    Palm_thioest; Palmitoyl protein thioesterase

  4. NM_001302396.1 → NP_001289325.1  lysosomal thioesterase PPT2 precursor

    See identical proteins and their annotated locations for NP_001289325.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All the variants encode the same protein.
    Source sequence(s)
    CO044617, CT009767, CX201936, CX202053, CX217389
    Consensus CDS
    CCDS28652.1
    UniProtKB/Swiss-Prot
    O35448, Q80WP5
    UniProtKB/TrEMBL
    F6SPQ1
    Related
    ENSMUSP00000127745.3, ENSMUST00000171121.9
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 276
    Palm_thioest; Palmitoyl protein thioesterase

  5. NM_019441.5 → NP_062314.1  lysosomal thioesterase PPT2 precursor

    See identical proteins and their annotated locations for NP_062314.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All the variants encode the same protein.
    Source sequence(s)
    AK002301, CO044617, CT009767, CX201936, CX221820, CX565661
    Consensus CDS
    CCDS28652.1
    UniProtKB/Swiss-Prot
    O35448, Q80WP5
    UniProtKB/TrEMBL
    F6SPQ1
    Related
    ENSMUSP00000131243.2, ENSMUST00000171376.8
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 276
    Palm_thioest; Palmitoyl protein thioesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34835636..34856993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524638.4 → XP_006524701.1  lysosomal thioesterase PPT2 isoform X2

    See identical proteins and their annotated locations for XP_006524701.1

    UniProtKB/Swiss-Prot
    O35448, Q80WP5
    UniProtKB/TrEMBL
    F6SPQ1
    Conserved Domains (1) summary
    pfam02089
    Location:38 → 276
    Palm_thioest; Palmitoyl protein thioesterase

  2. XM_006524634.5 → XP_006524697.1  lysosomal thioesterase PPT2 isoform X1

    See identical proteins and their annotated locations for XP_006524697.1

    Conserved Domains (1) summary
    pfam02089
    Location:54 → 292
    Palm_thioest; Palmitoyl protein thioesterase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35448.1 GenPept UniProtKB/Swiss-Prot:O35448

Gene LinkOut

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