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Phc2 polyhomeotic 2 [ Mus musculus (house mouse) ]

Gene ID: 54383, updated on 21-Apr-2024

Summary

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Official Symbol
Phc2provided by MGI
Official Full Name
polyhomeotic 2provided by MGI
Primary source
MGI:MGI:1860454
See related
Ensembl:ENSMUSG00000028796 AllianceGenome:MGI:1860454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p36; Edr2; Mph2; A3galt2; D4Ertd810e; D130050K19Rik
Summary
Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in heterochromatin and nucleus. Part of PcG protein complex. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human PHC2 (polyhomeotic homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.0), ovary adult (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 62.12 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128548448..128646674)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (128654655..128752881)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11454 Neighboring gene toll-like receptor 12 Neighboring gene STARR-seq mESC enhancer starr_11455 Neighboring gene predicted gene 12958 Neighboring gene STARR-positive B cell enhancer ABC_E9239 Neighboring gene STARR-positive B cell enhancer ABC_E6219 Neighboring gene VISTA enhancer mm1684 Neighboring gene predicted gene, 33712 Neighboring gene STARR-seq mESC enhancer starr_11460 Neighboring gene STARR-positive B cell enhancer ABC_E9595 Neighboring gene alpha 1,3-galactosyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E3514 Neighboring gene zinc finger protein 362 Neighboring gene predicted gene, 52679

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation. Cho KW, et al. In Vitro Cell Dev Biol Anim, 2013 May. PMID 23605804
  2. Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression. Bae J, et al. Nat Commun, 2019 Aug 2. PMID 31375680, Free PMC Article
  3. Mph2 expression in germinal zones of the mouse brain. Kim MH, et al. Dev Dyn, 2005 Jan. PMID 15580621
  4. The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Hemenway CS, et al. Oncogene, 1998 May 14. PMID 9627119
  5. Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family. Tonkin E, et al. Hum Genet, 2002 Oct. PMID 12384788

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study demonstrates that Phc2 regulates hematopoietic stem and progenitor cells mobilization through the repression of Vcam1 expression by enhancing both H3K27me3 and H2AK119ub in bone marrow stromal cells.
    Title: Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression.
  2. polymerization of the Phc2 SAM domain is required for PRC1 clustering, chromatin condensation and gene silencing.
    Title: SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing.
  3. Phc2 may act as a negative regulator that inhibits the activity of Th cells.
    Title: Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation.
  4. functional overlap between Phc2 and Phc1 along with a strict dose-dependent requirement during anterior-posterior (A-P) patterning
    Title: Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes.
  5. Mph2 is expressed in the ventricular zones of the cortex and ganglionic eminences as well as in mature structures such as the granule cell layer of the adult dentate gyrus and cerebellum; it has roles in both the developing and adult brain
    Title: Mph2 expression in germinal zones of the mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polyhomeotic-like protein 2
Names
early development regulator 2
early development regulatory protein 2
polyhomeotic 2 protein
polyhomeotic-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195083.1 → NP_001182012.1  polyhomeotic-like protein 2 isoform B

    See identical proteins and their annotated locations for NP_001182012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks 8 coding exons in the 5' region, and initiates translation at a downstream AUG, compared to variant 1. The resulting protein (isoform B) has a shorter N-terminus, compared to isoform A.
    Source sequence(s)
    AL611983
    Consensus CDS
    CCDS57297.1
    UniProtKB/Swiss-Prot
    Q9QWH1
    Related
    ENSMUSP00000101689.4, ENSMUST00000106079.10
    Conserved Domains (2) summary
    cd09577
    Location:254 → 322
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    pfam16616
    Location:135 → 254
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

  2. NM_001195130.1 → NP_001182059.1  polyhomeotic-like protein 2 isoform A

    See identical proteins and their annotated locations for NP_001182059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform A).
    Source sequence(s)
    AL611969, AL611983
    Consensus CDS
    CCDS18674.1
    UniProtKB/Swiss-Prot
    B1AS98, B1ASA4, O88463, Q8K5D9, Q9QWH1
    UniProtKB/TrEMBL
    B2KFW6
    Related
    ENSMUSP00000030588.7, ENSMUST00000030588.13
    Conserved Domains (3) summary
    cd09577
    Location:781 → 849
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    PHA03247
    Location:216 → 540
    PHA03247; large tegument protein UL36; Provisional
    pfam16616
    Location:662 → 780
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

  3. NM_018774.4 → NP_061244.1  polyhomeotic-like protein 2 isoform A

    See identical proteins and their annotated locations for NP_061244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Both variants 1 and 2 encode the same protein (isoform A).
    Source sequence(s)
    AL611969, BC057571, BE995150
    Consensus CDS
    CCDS18674.1
    UniProtKB/Swiss-Prot
    B1AS98, B1ASA4, O88463, Q8K5D9, Q9QWH1
    UniProtKB/TrEMBL
    B2KFW6
    Related
    ENSMUSP00000101690.2, ENSMUST00000106080.8
    Conserved Domains (3) summary
    cd09577
    Location:781 → 849
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    PHA03247
    Location:216 → 540
    PHA03247; large tegument protein UL36; Provisional
    pfam16616
    Location:662 → 780
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    128548448..128646674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240576.4 → XP_011238878.1  polyhomeotic-like protein 2 isoform X3

    Conserved Domains (1) summary
    PHA03247
    Location:216 → 499
    PHA03247; large tegument protein UL36; Provisional

  2. XM_006503234.3 → XP_006503297.1  polyhomeotic-like protein 2 isoform X2

    UniProtKB/TrEMBL
    B2KFW6
    Conserved Domains (3) summary
    cd09577
    Location:752 → 820
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    PHA03247
    Location:219 → 511
    PHA03247; large tegument protein UL36; Provisional
    pfam16616
    Location:633 → 751
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

  3. XM_017320320.1 → XP_017175809.1  polyhomeotic-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B1AS98, B1ASA4, O88463, Q8K5D9, Q9QWH1
    UniProtKB/TrEMBL
    B2KFW6
    Conserved Domains (3) summary
    cd09577
    Location:781 → 849
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    PHA03247
    Location:216 → 540
    PHA03247; large tegument protein UL36; Provisional
    pfam16616
    Location:662 → 780
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

  4. XM_036164241.1 → XP_036020134.1  polyhomeotic-like protein 2 isoform X5

    Conserved Domains (2) summary
    cd09577
    Location:254 → 322
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    pfam16616
    Location:135 → 254
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

  5. XM_006503236.1 → XP_006503299.1  polyhomeotic-like protein 2 isoform X4

    Conserved Domains (2) summary
    cd09577
    Location:296 → 364
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    pfam16616
    Location:177 → 295
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

  6. XM_006503238.1 → XP_006503301.1  polyhomeotic-like protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006503301.1

    UniProtKB/Swiss-Prot
    Q9QWH1
    Conserved Domains (2) summary
    cd09577
    Location:254 → 322
    SAM_Ph1,2,3; SAM domain of Ph (polyhomeotic) proteins of Polycomb group
    pfam16616
    Location:135 → 254
    PHC2_SAM_assoc; Unstructured region on Polyhomeotic-like protein 1 and 2

RNA

  1. XR_376334.4 RNA Sequence

  2. XR_004941936.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWH1.1 GenPept UniProtKB/Swiss-Prot:Q9QWH1

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