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Zfp326 zinc finger protein 326 [ Mus musculus (house mouse) ]

Gene ID: 54367, updated on 21-Apr-2024

Summary

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Official Symbol
Zfp326provided by MGI
Official Full Name
zinc finger protein 326provided by MGI
Primary source
MGI:MGI:1927246
See related
Ensembl:ENSMUSG00000029290 AllianceGenome:MGI:1927246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZAN75; Znf326; 5730470H14Rik
Summary
Enables DNA binding activity and zinc ion binding activity. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in nuclear matrix. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human ZNF326 (zinc finger protein 326). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 13.2), CNS E14 (RPKM 9.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E5; 5 50.88 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (106024422..106063684)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105876556..105915818)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54332 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 19566 Neighboring gene predicted gene, 25672

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response. Liou YJ, et al. PLoS One, 2012. PMID 22666313, Free PMC Article
  2. Characterization of a zinc finger protein ZAN75: nuclear localization signal, transcriptional activator activity, and expression during neuronal differentiation of P19 cells. Lee JY, et al. DNA Cell Biol, 2000 Apr. PMID 10798446
  3. Cloning and characterization of a novel zinc finger protein that associates with nuclear matrix. Lee JY, et al. DNA Cell Biol, 1998 Oct. PMID 9809746
  4. Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells. Koso H, et al. Proc Natl Acad Sci U S A, 2012 Oct 30. PMID 23045694, Free PMC Article
  5. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. involvement of the Zfp326 and ZNF326 genes in antidepressant treatment response
    Title: Convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DBIRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DBIRD complex ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DBIRD complex subunit ZNF326
Names
zinc finger protein interacting with mRNPs
zinc finger protein-associated with nuclear matrix of 75 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018759.2 → NP_061229.2  DBIRD complex subunit ZNF326

    See identical proteins and their annotated locations for NP_061229.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a zinc finger protein.
    Source sequence(s)
    AK017693, AV503563, DR754281
    Consensus CDS
    CCDS19496.1
    UniProtKB/Swiss-Prot
    O88291, Q05DP5, Q3TRI9, Q3UJI3, Q8BSJ5, Q8K1X9, Q9CYG9
    UniProtKB/TrEMBL
    A0A0R4J098
    Related
    ENSMUSP00000031227.5, ENSMUST00000031227.11
    Conserved Domains (1) summary
    pfam04988
    Location:337 → 472
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

RNA

  1. NR_030777.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has alternate splice sites in the 5' coding region, as compared to variant 1. The resulting transcript is a nonsense-mediated mRNA decay (NMD) candidate, so is probably not making a protein.
    Source sequence(s)
    AK017693, AV503563, BU503985, DR754281

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    106024422..106063684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535131.4 → XP_006535194.1  DBIRD complex subunit ZNF326 isoform X2

    See identical proteins and their annotated locations for XP_006535194.1

    Conserved Domains (1) summary
    pfam04988
    Location:131 → 266
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

  2. XM_036165311.1 → XP_036021204.1  DBIRD complex subunit ZNF326 isoform X2

    Conserved Domains (1) summary
    pfam04988
    Location:131 → 266
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

  3. XM_030254703.2 → XP_030110563.1  DBIRD complex subunit ZNF326 isoform X2

    Conserved Domains (1) summary
    pfam04988
    Location:131 → 266
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

  4. XM_036165312.1 → XP_036021205.1  DBIRD complex subunit ZNF326 isoform X2

    Conserved Domains (1) summary
    pfam04988
    Location:131 → 266
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

  5. XM_006535128.5 → XP_006535191.1  DBIRD complex subunit ZNF326 isoform X1

    See identical proteins and their annotated locations for XP_006535191.1

    UniProtKB/Swiss-Prot
    O88291, Q05DP5, Q3TRI9, Q3UJI3, Q8BSJ5, Q8K1X9, Q9CYG9
    Conserved Domains (1) summary
    pfam04988
    Location:291 → 456
    AKAP95; A-kinase anchoring protein 95 (AKAP95)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88291.1 GenPept UniProtKB/Swiss-Prot:O88291

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