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Epb41l4b erythrocyte membrane protein band 4.1 like 4b [ Mus musculus (house mouse) ]

Gene ID: 54357, updated on 18-Apr-2024

Summary

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Official Symbol
Epb41l4bprovided by MGI
Official Full Name
erythrocyte membrane protein band 4.1 like 4bprovided by MGI
Primary source
MGI:MGI:1859149
See related
Ensembl:ENSMUSG00000028434 AllianceGenome:MGI:1859149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ehm2; Lulu2; Epb4.1l4b; D4Ertd346e; 6430543G08Rik
Summary
Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in several processes, including actomyosin structure organization; positive regulation of keratinocyte migration; and wound healing. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Predicted to be active in cytoskeleton. Is expressed in several structures, including cartilage; genitourinary system; gut; nervous system; and skin. Orthologous to human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 21.1), colon adult (RPKM 11.0) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B3; 4 31.66 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (56991977..57143753, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (56991972..57143168, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 245 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:56928950-56929103 Neighboring gene STARR-seq mESC enhancer starr_10314 Neighboring gene predicted gene, 22300 Neighboring gene STARR-seq mESC enhancer starr_10316 Neighboring gene ferric-chelate reductase 1 like Neighboring gene predicted gene, 34738 Neighboring gene STARR-seq mESC enhancer starr_10320 Neighboring gene predicted gene, 34802 Neighboring gene predicted gene 12530

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of genes differentially expressed in association with metastatic potential of K-1735 murine melanoma by messenger RNA differential display. Hashimoto Y, et al. Cancer Res, 1996 Nov 15. PMID 8912867
  2. Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, ehm2, that is expressed in high-metastatic K1735 murine melanoma cells. Shimizu K, et al. Genomics, 2000 Apr 15. PMID 10783258
  3. Cloning, characterization, and genomic structure of the mouse Ikbkap gene. Cuajungco MP, et al. DNA Cell Biol, 2001 Sep. PMID 11747609
  4. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. Nakajima H, et al. J Cell Biol, 2011 Oct 17. PMID 22006950, Free PMC Article
  5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
band 4.1-like protein 4B
Names
erythrocyte protein band 4.1-like 4b
erythrocyte protein band 4.1-like 4b; expressed in high-metastatic cells
expressed in high-metastatic cells

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355492.2 → NP_001342421.1  band 4.1-like protein 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL805921, AL831761
    Conserved Domains (3) summary
    smart00295
    Location:87 → 277
    B41; Band 4.1 homologues
    cd13186
    Location:273 → 366
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:379 → 419
    FA; FERM adjacent (FA)

  2. NM_001424796.1 → NP_001411725.1  band 4.1-like protein 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL805921, AL831761

  3. NM_019427.3 → NP_062300.2  band 4.1-like protein 4B isoform 1

    See identical proteins and their annotated locations for NP_062300.2

    Status: VALIDATED

    Source sequence(s)
    AL805921, AL831761
    Consensus CDS
    CCDS51180.1
    UniProtKB/Swiss-Prot
    A2ALK7, Q9JMC8
    UniProtKB/TrEMBL
    Q3TMR3
    Related
    ENSMUSP00000030142.4, ENSMUST00000030142.4
    Conserved Domains (5) summary
    smart00295
    Location:87 → 277
    B41; Band 4.1 homologues
    cd13186
    Location:273 → 366
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam00373
    Location:170 → 277
    FERM_M; FERM central domain
    pfam08736
    Location:379 → 419
    FA; FERM adjacent (FA)
    pfam09379
    Location:89 → 151
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    56991977..57143753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164240.1 → XP_036020133.1  band 4.1-like protein 4B isoform X5

    Conserved Domains (2) summary
    pfam08736
    Location:78 → 119
    FA; FERM adjacent (FA)
    cl17171
    Location:10 → 65
    PH-like; Pleckstrin homology-like domain

  2. XM_011250068.2 → XP_011248370.1  band 4.1-like protein 4B isoform X2

    Conserved Domains (3) summary
    smart00295
    Location:87 → 277
    B41; Band 4.1 homologues
    cd13186
    Location:273 → 366
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:379 → 419
    FA; FERM adjacent (FA)

  3. XM_006538087.4 → XP_006538150.1  band 4.1-like protein 4B isoform X1

    UniProtKB/TrEMBL
    A2ALK6
    Related
    ENSMUSP00000092687.4, ENSMUST00000095076.10
    Conserved Domains (3) summary
    smart00295
    Location:87 → 277
    B41; Band 4.1 homologues
    cd13186
    Location:273 → 366
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:379 → 419
    FA; FERM adjacent (FA)

  4. XM_006538089.5 → XP_006538152.1  band 4.1-like protein 4B isoform X4

    Conserved Domains (4) summary
    smart00295
    Location:87 → 277
    B41; Band 4.1 homologues
    pfam06495
    Location:332 → 498
    Transformer; Fruit fly transformer protein
    cd13186
    Location:273 → 366
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:379 → 419
    FA; FERM adjacent (FA)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMC8.2 GenPept UniProtKB/Swiss-Prot:Q9JMC8

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