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Atf7ip activating transcription factor 7 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 54343, updated on 18-Apr-2024

Summary

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Official Symbol
Atf7ipprovided by MGI
Official Full Name
activating transcription factor 7 interacting proteinprovided by MGI
Primary source
MGI:MGI:1858965
See related
Ensembl:ENSMUSG00000030213 AllianceGenome:MGI:1858965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AM; Mcaf1; 2610204M12Rik; 5830415B17Rik
Summary
Enables ATP hydrolysis activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; male reproductive gland or organ; and sensory organ. Orthologous to human ATF7IP (activating transcription factor 7 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.1), whole brain E14.5 (RPKM 7.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6; 6 G1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136495787..136587848)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136518789..136610850)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136440301-136440484 Neighboring gene ribosomal protein L36A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_17596 Neighboring gene predicted gene, 44140 Neighboring gene coenzyme Q2 homolog, prenyltransferase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E691 Neighboring gene STARR-positive B cell enhancer ABC_E9106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:136480481-136480679 Neighboring gene STARR-seq mESC enhancer starr_17599 Neighboring gene STARR-positive B cell enhancer ABC_E9282 Neighboring gene STARR-positive B cell enhancer ABC_E1715 Neighboring gene STARR-positive B cell enhancer ABC_E10415 Neighboring gene STARR-seq mESC enhancer starr_17605 Neighboring gene phospholipase B domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E4875 Neighboring gene predicted gene, 40409 Neighboring gene protein S100-A10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8(+) T Cell Effector and Memory Responses. Sin JH, et al. J Immunol, 2022 Mar 1. PMID 35110421, Free PMC Article
  2. The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex. Tsusaka T, et al. Epigenetics Chromatin, 2020 Nov 30. PMID 33256805, Free PMC Article
  3. Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor. Hu G, et al. Int J Mol Sci, 2023 Feb 21. PMID 36901736, Free PMC Article
  4. The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. Sin JH, et al. J Exp Med, 2019 Sep 2. PMID 31217192, Free PMC Article
  5. Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation. Uchimura Y, et al. J Biol Chem, 2006 Aug 11. PMID 16757475

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.
    Title: Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.
  2. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8(+) T Cell Effector and Memory Responses.
    Title: ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8(+) T Cell Effector and Memory Responses.
  3. The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex.
    Title: The fibronectin type-III (FNIII) domain of ATF7IP contributes to efficient transcriptional silencing mediated by the SETDB1 complex.
  4. ATF7ip is an inhibitor of Il2 gene expression
    Title: The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.
  5. We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance
    Title: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
  6. mAM/hAM facilitates conversion of H3-K9 dimethyl to trimethyl by ESET/SETDB1
    Title: mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
activating transcription factor 7-interacting protein 1
Names
ATFa-associated Modulator
MBD1-containing chromatin-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388194.1 → NP_001375123.1  activating transcription factor 7-interacting protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Conserved Domains (5) summary
    PHA03247
    Location:869 → 1213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601 → 812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1199 → 1299
    fn3_4; Fibronectin-III type domain

  2. NM_001388195.1 → NP_001375124.1  activating transcription factor 7-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Conserved Domains (5) summary
    PHA03247
    Location:868 → 1212
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598 → 811
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1198 → 1298
    fn3_4; Fibronectin-III type domain

  3. NM_001388196.1 → NP_001375125.1  activating transcription factor 7-interacting protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Conserved Domains (5) summary
    PHA03247
    Location:866 → 1208
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598 → 809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1194 → 1294
    fn3_4; Fibronectin-III type domain

  4. NM_001388197.1 → NP_001375126.1  activating transcription factor 7-interacting protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Conserved Domains (3) summary
    PHA03247
    Location:271 → 615
    PHA03247; large tegument protein UL36; Provisional
    pfam16788
    Location:3 → 214
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:601 → 701
    fn3_4; Fibronectin-III type domain

  5. NM_019426.3 → NP_062299.2  activating transcription factor 7-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_062299.2

    Status: VALIDATED

    Source sequence(s)
    AC124779, AC134474
    Consensus CDS
    CCDS20651.1
    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Related
    ENSMUSP00000032335.7, ENSMUST00000032335.13
    Conserved Domains (5) summary
    PHA03247
    Location:866 → 1210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598 → 809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1196 → 1296
    fn3_4; Fibronectin-III type domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    136495787..136587848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166296.1 → XP_036022189.1  activating transcription factor 7-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Conserved Domains (5) summary
    PHA03247
    Location:866 → 1210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598 → 809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1196 → 1296
    fn3_4; Fibronectin-III type domain

  2. XM_036166295.1 → XP_036022188.1  activating transcription factor 7-interacting protein 1 isoform X1

    Conserved Domains (5) summary
    PHA03247
    Location:869 → 1213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601 → 812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1199 → 1299
    fn3_4; Fibronectin-III type domain

  3. XM_017321681.3 → XP_017177170.1  activating transcription factor 7-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Conserved Domains (5) summary
    PHA03247
    Location:866 → 1210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598 → 809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1196 → 1296
    fn3_4; Fibronectin-III type domain

  4. XM_006506390.5 → XP_006506453.1  activating transcription factor 7-interacting protein 1 isoform X3

    Conserved Domains (5) summary
    PHA03247
    Location:877 → 1221
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:91 → 370
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:298 → 634
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:609 → 820
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1207 → 1307
    fn3_4; Fibronectin-III type domain

  5. XM_030255502.2 → XP_030111362.1  activating transcription factor 7-interacting protein 1 isoform X4

    Conserved Domains (5) summary
    PHA03247
    Location:874 → 1218
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:91 → 370
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:298 → 631
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:606 → 817
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1204 → 1304
    fn3_4; Fibronectin-III type domain

  6. XM_006506388.5 → XP_006506451.2  activating transcription factor 7-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006506451.2

    Conserved Domains (5) summary
    PHA03247
    Location:869 → 1213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601 → 812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1199 → 1299
    fn3_4; Fibronectin-III type domain

  7. XM_006506389.5 → XP_006506452.2  activating transcription factor 7-interacting protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006506452.2

    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Conserved Domains (5) summary
    PHA03247
    Location:866 → 1210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598 → 809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1196 → 1296
    fn3_4; Fibronectin-III type domain

  8. XM_036166294.1 → XP_036022187.1  activating transcription factor 7-interacting protein 1 isoform X1

    Conserved Domains (5) summary
    PHA03247
    Location:869 → 1213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601 → 812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1199 → 1299
    fn3_4; Fibronectin-III type domain

  9. XM_030255503.2 → XP_030111363.1  activating transcription factor 7-interacting protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TJ86, Q3TZW1, Q3UVK5, Q3UYZ7, Q7TT18, Q80ZK7, Q8C4A1, Q9JK31
    Conserved Domains (5) summary
    PHA03247
    Location:866 → 1210
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 623
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:598 → 809
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1196 → 1296
    fn3_4; Fibronectin-III type domain

  10. XM_006506392.3 → XP_006506455.1  activating transcription factor 7-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006506455.1

    Conserved Domains (5) summary
    PHA03247
    Location:869 → 1213
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:83 → 362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5271
    Location:290 → 626
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam16788
    Location:601 → 812
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:1199 → 1299
    fn3_4; Fibronectin-III type domain

RNA

  1. XR_004942987.1 RNA Sequence

  2. XR_004942986.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TT18.1 GenPept UniProtKB/Swiss-Prot:Q7TT18

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