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Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 54342, updated on 3-Apr-2024

Summary

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Official Symbol
Gnpnat1provided by MGI
Official Full Name
glucosamine-phosphate N-acetyltransferase 1provided by MGI
Primary source
MGI:MGI:1858963
See related
Ensembl:ENSMUSG00000037722 AllianceGenome:MGI:1858963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EMeg32; Gpnat1; Gsnpat
Summary
Enables glucosamine 6-phosphate N-acetyltransferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and late endosome. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and sensory organ. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 7.7), liver E18 (RPKM 6.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C1; 14 22.92 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45613897..45626972, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45376421..45388987, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene STARR-positive B cell enhancer ABC_E3110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:45949463-45949646 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 Neighboring gene serine/threonine/tyrosine interaction protein Neighboring gene STARR-seq mESC enhancer starr_36535 Neighboring gene predicted gene, 41143 Neighboring gene STARR-seq mESC enhancer starr_36537 Neighboring gene predicted gene, 34250

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association. Boehmelt G, et al. J Biol Chem, 2000 Apr 28. PMID 10777580
  2. Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. Boehmelt G, et al. EMBO J, 2000 Oct 2. PMID 11013212, Free PMC Article
  3. Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. Inohara N, et al. J Biol Chem, 1998 Apr 10. PMID 9535847
  4. Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Uijtdewilligen PJE, et al. Biomed Res Int, 2018. PMID 30228991, Free PMC Article
  5. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables glucosamine 6-phosphate N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosamine 6-phosphate N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucosamine 6-phosphate N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within UDP-N-acetylglucosamine biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucosamine 6-phosphate N-acetyltransferase
Names
glucosamine-6-phosphate acetyltransferase
glucosamine-phosphate N-acetyltransferase 1; glucosamine-6-phosphate acetyltransferase; glucosamine-phosphate N-acetyltransferase
phosphoglucosamine acetylase
phosphoglucosamine transacetylase
NP_001404467.1
NP_001404468.1
NP_001404469.1
NP_001404470.1
NP_001404471.1
NP_001404472.1
NP_001404473.1
NP_001404474.1
NP_001404475.1
NP_001404476.1
NP_001404478.1
NP_001404479.1
NP_062298.1
XP_036014653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417538.1 → NP_001404467.1  glucosamine 6-phosphate N-acetyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT025535
    UniProtKB/TrEMBL
    A0A2I3BQY4
    Related
    ENSMUSP00000154382.2, ENSMUST00000226276.2

  2. NM_001417539.1 → NP_001404468.1  glucosamine 6-phosphate N-acetyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025535

  3. NM_001417540.1 → NP_001404469.1  glucosamine 6-phosphate N-acetyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025535

  4. NM_001417541.1 → NP_001404470.1  glucosamine 6-phosphate N-acetyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT025535

  5. NM_001417542.1 → NP_001404471.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025535
    UniProtKB/Swiss-Prot
    Q9JK38

  6. NM_001417543.1 → NP_001404472.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025535
    UniProtKB/Swiss-Prot
    Q9JK38

  7. NM_001417544.1 → NP_001404473.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025535
    UniProtKB/Swiss-Prot
    Q9JK38

  8. NM_001417545.1 → NP_001404474.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025535
    UniProtKB/Swiss-Prot
    Q9JK38

  9. NM_001417546.1 → NP_001404475.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025535
    UniProtKB/Swiss-Prot
    Q9JK38

  10. NM_001417547.1 → NP_001404476.1  glucosamine 6-phosphate N-acetyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT025535

  11. NM_001417549.1 → NP_001404478.1  glucosamine 6-phosphate N-acetyltransferase isoform 6

    Status: VALIDATED

    Source sequence(s)
    CT025535
    Related
    ENSMUSP00000154777.2, ENSMUST00000227865.2

  12. NM_001417550.1 → NP_001404479.1  glucosamine 6-phosphate N-acetyltransferase isoform 6

    Status: VALIDATED

    Source sequence(s)
    CT025535

  13. NM_019425.3 → NP_062298.1  glucosamine 6-phosphate N-acetyltransferase isoform 4

    See identical proteins and their annotated locations for NP_062298.1

    Status: VALIDATED

    Source sequence(s)
    CT025535
    Consensus CDS
    CCDS26976.1
    UniProtKB/Swiss-Prot
    Q9JK38
    UniProtKB/TrEMBL
    Q3THZ8
    Related
    ENSMUSP00000042860.8, ENSMUST00000046191.9
    Conserved Domains (1) summary
    cl17182
    Location:36 → 174
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    45613897..45626972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158760.1 → XP_036014653.1  glucosamine 6-phosphate N-acetyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q9JK38
    UniProtKB/TrEMBL
    Q3THZ8
    Conserved Domains (1) summary
    cl17182
    Location:36 → 174
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JK38.1 GenPept UniProtKB/Swiss-Prot:Q9JK38

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