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B3galt4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 54218, updated on 5-Mar-2024

Summary

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Official Symbol
B3galt4provided by MGI
Official Full Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4provided by MGI
Primary source
MGI:MGI:1859517
See related
Ensembl:ENSMUSG00000067370 AllianceGenome:MGI:1859517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Galt2; Gal-T2
Summary
Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in ganglioside biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human B3GALT4 (beta-1,3-galactosyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34168886..34170462, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33949912..33951488, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1938 Neighboring gene prefoldin subunit 6 Neighboring gene WD repeat domain 46 Neighboring gene STARR-positive B cell enhancer ABC_E8668 Neighboring gene ribosomal protein S18 Neighboring gene STARR-positive B cell enhancer ABC_E3199 Neighboring gene VPS52 GARP complex subunit Neighboring gene predicted gene, 23111

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma. Sha YL, et al. J Exp Clin Cancer Res, 2022 Oct 25. PMID 36284313, Free PMC Article
  2. ETS-1 transcription factor activates the expression of mouse UDP-Gal:GA2/GM2/GD2/GT2 galactosyltransferase gene. Raimondi LP, et al. FEBS Lett, 2004 Oct 22. PMID 15498585
  3. Mouse beta 1,3-galactosyltransferase (GA1/GM1/GD1b synthase): protein characterization, tissue expression, and developmental regulation in neural retina. Daniotti JL, et al. J Neurosci Res, 1999 Oct 15. PMID 10502288
  4. The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene. Logunova N, et al. PLoS Genet, 2015 Nov. PMID 26618355, Free PMC Article
  5. Developmental changes of glycosphingolipids and expression of glycogenes in mouse brains. Ngamukote S, et al. J Neurochem, 2007 Dec. PMID 17883393

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma.
    Title: B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma.
  2. activation of a fragment of 211 bp around the transcription initiation site of the mouse Gal-T2 promoter.
    Title: ETS-1 transcription factor activates the expression of mouse UDP-Gal:GA2/GM2/GD2/GT2 galactosyltransferase gene.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ganglioside galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,3-galactosyltransferase 4
Names
UDP-Gal:betaGlcNAc beta 13-galactosyltransferase polypeptide 4
UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
b3Gal-T4
beta-1,3-GalTase 4
beta3Gal-T4
beta3GalT4
ganglioside galactosyltransferase
NP_062293.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019420.2 → NP_062293.1  beta-1,3-galactosyltransferase 4 precursor

    See identical proteins and their annotated locations for NP_062293.1

    Status: VALIDATED

    Source sequence(s)
    AF082504, BY348346
    Consensus CDS
    CCDS28638.1
    UniProtKB/Swiss-Prot
    Q91VC1, Q920U8, Q920U9, Q9Z0F0
    UniProtKB/TrEMBL
    A0A068BIS6
    Related
    ENSMUSP00000084823.3, ENSMUST00000087543.5
    Conserved Domains (1) summary
    pfam01762
    Location:85 → 301
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34168886..34170462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0F0.1 GenPept UniProtKB/Swiss-Prot:Q9Z0F0

Gene LinkOut

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