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Golga4 golgin A4 [ Mus musculus (house mouse) ]

Gene ID: 54214, updated on 21-Apr-2024

Summary

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Official Symbol
Golga4provided by MGI
Official Full Name
golgin A4provided by MGI
Primary source
MGI:MGI:1859646
See related
Ensembl:ENSMUSG00000038708 AllianceGenome:MGI:1859646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Olp-1
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane protein transport and positive regulation of axon extension. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GOLGA4 (golgin A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.1), placenta adult (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F3; 9 70.23 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118335280..118411587)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118506196..118582519)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33408 Neighboring gene STARR-seq mESC enhancer starr_25456 Neighboring gene predicted gene, 33460 Neighboring gene eomesodermin Neighboring gene STARR-seq mESC enhancer starr_25460 Neighboring gene family with sequence similarity 64, member A pseudogene Neighboring gene integrin alpha 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118586586-118586773 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118623570-118623818 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118625206-118625362 Neighboring gene predicted gene 10157 Neighboring gene predicted gene, 39454

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice. Guo S, et al. Biochem Biophys Res Commun, 2020 Aug 27. PMID 32736686
  2. Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development. Cowan DA, et al. DNA Cell Biol, 2002 Jul. PMID 12162805
  3. OlP-1, a novel protein that distinguishes early oligodendrocyte precursors. Gay D, et al. J Neurosci Res, 1997 Nov 15. PMID 9404721
  4. A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo. Lieu ZZ, et al. Proc Natl Acad Sci U S A, 2008 Mar 4. PMID 18308930, Free PMC Article
  5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice.
    Title: GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice.
  2. golgin-245 is a key regulator of TNF secretion; LPS activation of macrophages results in increased Golgi carriers for export, up-regulating the transport pathway for TNF export.
    Title: A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo.
  3. Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development.
    Title: Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
golgin subfamily A member 4
Names
golgi autoantigen, golgin subfamily a, 4
golgin-245
tGolgin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410161.1 → NP_001397090.1  golgin subfamily A member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC173340, CT486004

  2. NM_001410162.1 → NP_001397091.1  golgin subfamily A member 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC173340, CT486004

  3. NM_018748.4 → NP_061218.2  golgin subfamily A member 4 isoform 1

    See identical proteins and their annotated locations for NP_061218.2

    Status: VALIDATED

    Source sequence(s)
    AC173340, CT486004
    Consensus CDS
    CCDS40801.1
    UniProtKB/Swiss-Prot
    O70365, Q8CGH6, Q91VW5
    Related
    ENSMUSP00000081880.5, ENSMUST00000084820.6
    Conserved Domains (5) summary
    pfam05483
    Location:492 → 1191
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    smart00755
    Location:2182 → 2225
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:1461 → 2148
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:880 → 1707
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl19219
    Location:880 → 956
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    118335280..118411587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155104.1 → XP_036010997.1  golgin subfamily A member 4 isoform X2

    Conserved Domains (3) summary
    smart00755
    Location:2221 → 2264
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:732 → 1531
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:197 → 1045
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_036155103.1 → XP_036010996.1  golgin subfamily A member 4 isoform X1

    Conserved Domains (3) summary
    smart00755
    Location:2222 → 2265
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:733 → 1532
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:197 → 1046
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_036155105.1 → XP_036010998.1  golgin subfamily A member 4 isoform X3

    Conserved Domains (3) summary
    smart00755
    Location:2222 → 2265
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:733 → 1532
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:197 → 1046
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_036155106.1 → XP_036010999.1  golgin subfamily A member 4 isoform X4

    Conserved Domains (3) summary
    smart00755
    Location:2221 → 2264
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:732 → 1531
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:197 → 1045
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_017313473.3 → XP_017168962.1  golgin subfamily A member 4 isoform X6

    Conserved Domains (4) summary
    smart00755
    Location:2214 → 2257
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:725 → 1524
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:363 → 1074
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:189 → 453
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  6. XM_036155107.1 → XP_036011000.1  golgin subfamily A member 4 isoform X8

    Conserved Domains (3) summary
    smart00755
    Location:2214 → 2257
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:725 → 1524
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:197 → 1038
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_036155108.1 → XP_036011001.1  golgin subfamily A member 4 isoform X9

    Conserved Domains (3) summary
    smart00755
    Location:2194 → 2237
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:705 → 1504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:197 → 1018
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_017313474.3 → XP_017168963.1  golgin subfamily A member 4 isoform X11

    Conserved Domains (3) summary
    smart00755
    Location:2187 → 2230
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:698 → 1497
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:339 → 1047
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_017313475.3 → XP_017168964.1  golgin subfamily A member 4 isoform X12

    Conserved Domains (3) summary
    smart00755
    Location:2186 → 2229
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:697 → 1496
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:339 → 1046
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  10. XM_036155111.1 → XP_036011004.1  golgin subfamily A member 4 isoform X14

    Conserved Domains (2) summary
    smart00755
    Location:2186 → 2229
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:697 → 1496
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. XM_036155109.1 → XP_036011002.1  golgin subfamily A member 4 isoform X10

    Conserved Domains (3) summary
    smart00755
    Location:2189 → 2232
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:700 → 1499
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:164 → 1017
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_017313477.3 → XP_017168966.1  golgin subfamily A member 4 isoform X16

    Conserved Domains (4) summary
    smart00755
    Location:2181 → 2224
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:692 → 1491
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:330 → 1041
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:156 → 420
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  13. XM_036155113.1 → XP_036011006.1  golgin subfamily A member 4 isoform X18

    Conserved Domains (3) summary
    smart00755
    Location:2161 → 2204
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:672 → 1471
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:164 → 989
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  14. XM_017313479.3 → XP_017168968.1  golgin subfamily A member 4 isoform X21

    Conserved Domains (3) summary
    smart00755
    Location:2153 → 2196
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:664 → 1463
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:306 → 1013
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  15. XM_036155115.1 → XP_036011008.1  golgin subfamily A member 4 isoform X22

    Conserved Domains (3) summary
    smart00755
    Location:1971 → 2014
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:482 → 1281
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:83 → 778
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  16. XM_036155117.1 → XP_036011010.1  golgin subfamily A member 4 isoform X26

    Conserved Domains (2) summary
    smart00755
    Location:1936 → 1979
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:447 → 1246
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  17. XM_017313478.2 → XP_017168967.1  golgin subfamily A member 4 isoform X19

    Conserved Domains (3) summary
    smart00755
    Location:2154 → 2197
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:665 → 1464
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:306 → 1014
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  18. XM_017313476.1 → XP_017168965.1  golgin subfamily A member 4 isoform X15

    Conserved Domains (4) summary
    smart00755
    Location:2182 → 2225
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:693 → 1492
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:301 → 1042
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:156 → 420
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  19. XM_006512187.5 → XP_006512250.1  golgin subfamily A member 4 isoform X5

    See identical proteins and their annotated locations for XP_006512250.1

    Conserved Domains (4) summary
    smart00755
    Location:2215 → 2258
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:726 → 1525
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:334 → 1075
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:189 → 453
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  20. XM_036155110.1 → XP_036011003.1  golgin subfamily A member 4 isoform X13

    Conserved Domains (2) summary
    smart00755
    Location:2187 → 2230
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:698 → 1497
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  21. XM_036155112.1 → XP_036011005.1  golgin subfamily A member 4 isoform X17

    Conserved Domains (3) summary
    smart00755
    Location:2164 → 2207
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:675 → 1474
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:139 → 988
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  22. XM_036155116.1 → XP_036011009.1  golgin subfamily A member 4 isoform X22

    Conserved Domains (3) summary
    smart00755
    Location:1971 → 2014
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:482 → 1281
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:83 → 778
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  23. XM_017313482.3 → XP_017168971.1  golgin subfamily A member 4 isoform X24

    Conserved Domains (3) summary
    smart00755
    Location:1963 → 2006
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:474 → 1273
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:112 → 823
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  24. XM_017313480.3 → XP_017168969.1  golgin subfamily A member 4 isoform X23

    Conserved Domains (3) summary
    smart00755
    Location:1964 → 2007
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:475 → 1274
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:83 → 824
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  25. XM_017313483.1 → XP_017168972.1  golgin subfamily A member 4 isoform X25

    Conserved Domains (3) summary
    smart00755
    Location:1963 → 2006
    Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
    COG1196
    Location:474 → 1273
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:112 → 823
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_004935483.1 RNA Sequence

  2. XR_004935484.1 RNA Sequence

  3. XR_004935487.1 RNA Sequence

  4. XR_004935486.1 RNA Sequence

  5. XR_004935488.1 RNA Sequence

  6. XR_004935485.1 RNA Sequence

  7. XR_004935489.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VW5.2 GenPept UniProtKB/Swiss-Prot:Q91VW5

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