Sult2b1 sulfotransferase family, cytosolic, 2B, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sult2b1provided by MGI
Official Full Name: sulfotransferase family, cytosolic, 2B, member 1provided by MGI
Primary source: MGI:MGI:1926342
See related: Ensembl:ENSMUSG00000003271 AllianceGenome:MGI:1926342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ST2B1; SULT2B
Summary: Enables sulfotransferase activity. Acts upstream of or within sulfate assimilation. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 14. Orthologous to human SULT2B1 (sulfotransferase family 2B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 60.2), large intestine adult (RPKM 56.9) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.47 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45379405..45409096, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45729981..45759672, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice.
Title: Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice.
The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1.
Title: The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1.
Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKbeta/NF-kappaB pathway in macrophages.
Title: Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKβ/NF-κB pathway in macrophages.
exerts inhibitory influences on castration-resistant prostate cancer
Title: Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer.
The abundant SULT2B1 expression in normal gastric epithelium might maintain epithelial function via the PI3K/AKT signaling pathway and suppress gastric carcinogenesis induced by a carcinogenic agent.
Title: Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent.
Study demonstrated that overexpression of hepatic SULT2B1b sensitized mice to acetaminophen (APAP)-induced liver damage, whereas ablation of Sult2B1b attenuated mice from APAP toxicity. These results pointed to SULT2B1b induction as a potential risk factor for APAP-induced acute liver damage.
Title: An Unexpected Role of Cholesterol Sulfotransferase and its Regulation in Sensitizing Mice to Acetaminophen-Induced Liver Injury.
The hydroxysteroid sulfotransferase 2B1b (SULT2B1b) overexpression promoted the epithelial-mesenchymal transition process in hepatocytes.
Title: SULT2B1b promotes epithelial-mesenchymal transition through activation of the β-catenin/MMP7 pathway in hepatocytes.
Data indicate that cholesterol sulfate (CS) and SULT2B1b inhibited gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha) in both cell cultures and human SULT2B1b transgenic mice.
Title: Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4α.
SULT2B1b may promote hepatocyte proliferation by inactivating oxysterol/LXR signaling.
Title: Cytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro.
increases in SULT2B1b expression were accompanied by reduction in key regulators and enzymes involved in lipid metabolism, including liver X receptor alpha, SREBP-1, SREBP-2, acetyl-CoA carboxylase-1, and fatty acid synthase.
Title: Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

General gene information

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Markers

BB173635 (e-PCR)
- UniSTS:185713

AI326997 (e-PCR)
- UniSTS:179573

AW523314 (e-PCR)
- UniSTS:261759

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alcohol sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables steroid hormone binding	ISO Inferred from Sequence Orthology more info
enables steroid sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sulfate assimilation	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sulfotransferase 2B1

Names: alcohol sulfotransferase; hydroxysteroid sulfotransferase 2; sulfotransferase 2B

NP_001347713.1

EC 2.8.2.2

NP_059493.2

EC 2.8.2.2

XP_006541061.1

EC 2.8.2.2

XP_006541062.1

EC 2.8.2.2

XP_030098652.1

EC 2.8.2.2

XP_030098653.1

EC 2.8.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360784.1 → NP_001347713.1 sulfotransferase 2B1 isoform 2

Status: VALIDATED

Source sequence(s)

AC167242, BM899747

Consensus CDS

CCDS90241.1

UniProtKB/TrEMBL

A0A1B0GR49, A0A1B0GST5

Related

ENSMUSP00000148064.2, ENSMUST00000210754.2

Conserved Domains (1) summary

pfam00685
Location:91 → 334

Sulfotransfer_1; Sulfotransferase domain
NM_017465.3 → NP_059493.2 sulfotransferase 2B1 isoform 1

See identical proteins and their annotated locations for NP_059493.2

Status: VALIDATED

Source sequence(s)

AC167242, AI851328, BM899747, CJ043038, CJ048619, CJ054084

Consensus CDS

CCDS21263.1

UniProtKB/Swiss-Prot

O35400, Q8K472, Q91V03

UniProtKB/TrEMBL

A0A1B0GR49

Related

ENSMUSP00000075005.8, ENSMUST00000075571.16

Conserved Domains (1) summary

pfam00685
Location:57 → 300

Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

45379405..45409096 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242793.1 → XP_030098653.1 sulfotransferase 2B1 isoform X2

UniProtKB/TrEMBL

A0A1B0GR49

Conserved Domains (1) summary

pfam00685
Location:18 → 261

Sulfotransfer_1; Sulfotransferase domain
XM_030242792.1 → XP_030098652.1 sulfotransferase 2B1 isoform X2

UniProtKB/TrEMBL

A0A1B0GR49

Conserved Domains (1) summary

pfam00685
Location:18 → 261

Sulfotransfer_1; Sulfotransferase domain
XM_006540999.2 → XP_006541062.1 sulfotransferase 2B1 isoform X2

UniProtKB/TrEMBL

A0A1B0GR49

Related

ENSMUSP00000147374.2, ENSMUST00000209739.2

Conserved Domains (1) summary

pfam00685
Location:18 → 261

Sulfotransfer_1; Sulfotransferase domain
XM_006540998.3 → XP_006541061.1 sulfotransferase 2B1 isoform X1

UniProtKB/TrEMBL

A0A1B0GR49

Conserved Domains (1) summary

pfam00685
Location:53 → 296

Sulfotransfer_1; Sulfotransferase domain